CALYCULIN A

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C50H81N4O15P
Molecular Weight	1009.1697
Optical Activity	UNSPECIFIED
Defined Stereocenters	15 / 15
E/Z Centers	5
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]1(O[C@]2(C[C@@H](O)[C@H](C)[C@H](C\C=C\C3=COC(=N3)[C@@H](C)CCNC(=O)[C@@H](O)[C@@H](O)[C@H](COC)N(C)C)O2)C(C)(C)[C@H]1OP(O)(O)=O)[C@H](C[C@H](O)[C@H](C)[C@H](O)[C@H](C)\C=C(C)\C(C)=C\C=C\C(C)=C/C#N)OC

InChI

InChIKey=FKAWLXNLHHIHLA-YCBIHMBMSA-N

InChI=1S/C50H81N4O15P/c1-29(20-22-51)16-14-17-30(2)32(4)24-33(5)42(57)35(7)38(55)25-41(65-13)45-46(69-70(61,62)63)49(8,9)50(68-45)26-39(56)34(6)40(67-50)19-15-18-36-27-66-48(53-36)31(3)21-23-52-47(60)44(59)43(58)37(28-64-12)54(10)11/h14-18,20,24,27,31,33-35,37-46,55-59H,19,21,23,25-26,28H2,1-13H3,(H,52,60)(H2,61,62,63)/b16-14+,18-15+,29-20-,30-17+,32-24+/t31-,33+,34-,35-,37-,38-,39+,40-,41-,42+,43-,44-,45+,46-,50+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C50H81N4O15P
Molecular Weight	1009.1697
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	15 / 15
E/Z Centers	5
Optical Activity	UNSPECIFIED

Approval Year

PubMed

Title	Date	PubMed
Signal transduction for nuclear factor-kappa B activation. Proposed location of antioxidant-inhibitable step.	1994 Dec 1	7963561
Protein phosphatase-protein kinase interplay modulates alpha 1b-adrenoceptor phosphorylation: effects of okadaic acid.	2000 Feb	10683197
ATP induces dephosphorylation of myosin light chain in endothelial cells.	2000 Sep	10942722
Serine/threonine phosphatase inhibitors decrease adrenergic arylalkylamine n-acetyltransferase induction in the rat pineal gland.	2001 Jul	11442772
Phosphorylation-dependent nucleocytoplasmic shuttling of pancreatic duodenal homeobox-1.	2001 Oct	11574405
Possible involvement of optimally phosphorylated L-plastin in activation of superoxide-generating NADPH oxidase.	2003 Dec	14769871
Alpha1-AR-mediated activation of NKCC in rat cardiomyocytes involves ERK-dependent phosphorylation of the cotransporter.	2004 Apr	14630635
Toxin-induced tail phosphorylation of hepatocellular S6 kinase: evidence for a dual involvement of the AMP-activated protein kinase in S6 kinase regulation.	2004 Dec	15342961
Calcium and protein phosphatase 1/2A attenuate N-methyl-D-aspartate receptor activity in the anoxic turtle cortex.	2005 Sep	16139540
Effect of aspirin on the Wnt/beta-catenin pathway is mediated via protein phosphatase 2A.	2006 Oct 19	16878161
Protein kinase C-mediated phosphorylation of the calcium-sensing receptor is stimulated by receptor activation and attenuated by calyculin-sensitive phosphatase activity.	2007 May 18	17376781
p66Shc links alpha1-adrenergic receptors to a reactive oxygen species-dependent AKT-FOXO3A phosphorylation pathway in cardiomyocytes.	2009 Mar 13	19168439
Calyculin A reveals serine/threonine phosphatase protein phosphatase 1 as a regulatory nodal point in canonical signal transducer and activator of transcription 3 signaling of human microvascular endothelial cells.	2012 Feb	22142222
Diphenyl ditelluride induces hypophosphorylation of intermediate filaments through modulation of DARPP-32-dependent pathways in cerebral cortex of young rats.	2012 Feb	21863293
A novel toxicogenomics-based approach to categorize (non-)genotoxic carcinogens.	2015 Dec	25270620

Substance Class	Chemical Created by `admin` on `Sat Dec 16 09:11:38 GMT 2023` Edited by `admin` on `Sat Dec 16 09:11:38 GMT 2023`
Record UNII	7D07U14TK3
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CALYCULIN A

Common Name

English

(-)-CALYCULIN A

Common Name

English

CALYCULIN A [MI]

Common Name

English

Code System Code Type Description

DRUG BANK

DB02860