RNA-binding motif protein 39

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 17:33:16 GMT 2025` Edited by `admin` on `Wed Apr 02 17:33:16 GMT 2025`
Protein Type	PEPTIDE
Protein Sub Type
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	7CGZ92983T
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CAPER alpha

Preferred Name

English

RNA-binding motif protein 39

Common Name

English

Hepatocellular carcinoma protein 1

Common Name

English

Splicing factor HCC1

Common Name

English

RBM39

Common Name

English

RNA-binding protein 39

Common Name

English

RNA-binding region-containing protein 2

Common Name

English

RBM-39

Common Name

English

Code System Code Type Description

DAILYMED

7CGZ92983T

Created by admin on Wed Apr 02 17:33:16 GMT 2025 , Edited by admin on Wed Apr 02 17:33:16 GMT 2025

PRIMARY

UNIPROT

Q14498

Created by admin on Wed Apr 02 17:33:16 GMT 2025 , Edited by admin on Wed Apr 02 17:33:16 GMT 2025

PRIMARY

FDA UNII

7CGZ92983T

Created by admin on Wed Apr 02 17:33:16 GMT 2025 , Edited by admin on Wed Apr 02 17:33:16 GMT 2025

PRIMARY

Related Record Type Details


					WJ98J3NM90

INDISULAM

DEGRADER->TARGET

Comments:

Indisulam induces a ternary protein complex between RNA Binding Motif 39 (RBM39) and the E3 ubiquitin ligase receptor DDB1 and CUL4 associated factor 15 (DCAF15) resulting in rapid proteasomal degradation of RBM39, aberrant RNA splicing and cell death.

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_96] [1_99] [1_116] [1_120] [1_135] [1_333] [1_336] [1_340]	SITE_SPECIFIC	S	DEXFOSFOSERINE	VI4F0K069V
AMINO_ACID_SUBSTITUTION	[1_1]	N-TERMINUS	A	N-ACETYLALANINE	26C4VY6Z0M
AMINO_ACID_SUBSTITUTION	[1_145]	SITE_SPECIFIC	T	THREONINE PHOSPHATE	3L4WX7B1EI
AMINO_ACID_SUBSTITUTION	[1_94]	SITE_SPECIFIC	Y	TYROSINE O-PHOSPHATE	2R86C98KDX

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL