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Details

Stereochemistry ACHIRAL
Molecular Formula C7H6N2
Molecular Weight 118.1359
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of INDAZOLE

SMILES

N1N=CC2=C1C=CC=C2

InChI

InChIKey=BAXOFTOLAUCFNW-UHFFFAOYSA-N
InChI=1S/C7H6N2/c1-2-4-7-6(3-1)5-8-9-7/h1-5H,(H,8,9)

HIDE SMILES / InChI

Molecular Formula C7H6N2
Molecular Weight 118.1359
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

PubMed

PubMed

TitleDatePubMed
The design of competitive, small-molecule inhibitors of coagulation factor Xa.
2001 Jun
Studies on synthetic approaches to 1H- and 2H-indazolyl derivatives.
2001 Jun 15
Azole. 47. Uber 3-thiomorpholino- und 3-(4-methylpiperazino)-5-nitroindazole.
2001 Oct
Male fertility: core chemical structure in pharmacological research.
2002 Apr
New N-pyridinyl(methyl)-indole-2- and 3-(alkyl)carboxamides and derivatives acting as systemic and topical inflammation inhibitors.
2002 Dec
7-Methoxy-1H-indazole, a new inhibitor of neuronal nitric oxide synthase.
2002 Nov
Mechanism of lonidamine inhibition of the CFTR chloride channel.
2002 Nov
Cyclization of 1-(2-alkynylphenyl)-3,3-dialkyltriazenes: a convenient, high-yield synthesis of substituted cinnolines and isoindazoles.
2002 Sep 6
Soluble guanylyl cyclase activator YC-1 inhibits human neutrophil functions through a cGMP-independent but cAMP-dependent pathway.
2003 Dec
Syntheses and antiproliferative activities of 7-azarebeccamycin analogues bearing one 7-azaindole moiety.
2003 Feb 13
Syntheses and antiproliferative activities of rebeccamycin analogues bearing two 7-azaindole moieties.
2003 Mar 6
Inhibitory effects and spectral interactions of isomeric methoxyindazoles on recombinant nitric oxide synthases.
2003 Sep
The isoindazole nucleus as a donor in fullerene-based dyads. Evidence for electron transfer.
2004 Apr 16
Design, synthesis and evaluation of bicyclic benzamides as novel 5-HT1F receptor agonists.
2004 Dec 20
Possible mechanism(s) for relaxant effect of aqueous and macerated extracts from Nigella sativa on tracheal chains of guinea pig.
2004 Feb 25
New antithrombotics with an indazole structure.
2004 Jun
Spatial orientation of the antagonist granisetron in the ligand-binding site of the 5-HT3 receptor.
2005 Aug
Inhibitive properties and surface morphology of a group of heterocyclic diazoles as inhibitors for acidic iron corrosion.
2005 Dec 20
From model compounds to protein binding: syntheses, characterizations and fluorescence studies of [RuII(bipy)(terpy)L]2+ complexes (bipy = 2,2'-bipyridine; terpy = 2,2':6',2''-terpyridine; L = imidazole, pyrazole and derivatives, cytochrome c).
2005 Jan 21
Comparative binding of antitumor indazolium [trans-tetrachlorobis(1H-indazole)ruthenate(III)] to serum transport proteins assayed by capillary zone electrophoresis.
2005 Jun 15
Metabolism of the calmodulin antagonist DY-9760e in animals and humans.
2005 May
YC-1 suppresses constitutive nuclear factor-kappaB activation and induces apoptosis in human prostate cancer cells.
2005 Oct
Relaxant effects of the soluble guanylate cyclase activator and NO sensitizer YC-1 in piglet pulmonary arteries.
2006
Prediction of the binding mode between BMS-378806 and HIV-1 gp120 by docking and molecular dynamics simulation.
2006 Apr
Recent advances in the solid-phase combinatorial synthetic strategies for the quinoxaline, quinazoline and benzimidazole based privileged structures.
2006 Jan
Structure-activity studies of a novel series of 5,6-fused heteroaromatic ureas as TRPV1 antagonists.
2006 Jul 15
Pyrazole complexes as anion receptors: effects of changing the metal, the pyrazole substitution pattern, and the number of pyrazole ligands.
2007 Apr 16
Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitors.
2007 Dec
A planar carboxylate-rich tetraironII complex and its conversion to linear triironII and paddlewheel diironII complexes.
2007 Dec 10
Design and synthesis of Rho kinase inhibitors (II).
2007 Jan 1
Development of dihydropyridone indazole amides as selective Rho-kinase inhibitors.
2007 Jan 11
QSAR analysis of indazole estrogens as selective beta-estrogen receptor ligands: rationalization of physicochemical properties.
2007 Jul
4-substituted indazoles as new inhibitors of neuronal nitric oxide synthase.
2007 Jun 1
Structure-activity relationships for NAMI-A-type complexes (HL)[trans-RuCl4L(S-dmso)ruthenate(III)] (L = imidazole, indazole, 1,2,4-triazole, 4-amino-1,2,4-triazole, and 1-methyl-1,2,4-triazole): aquation, redox properties, protein binding, and antiproliferative activity.
2007 May 3
GdCl(3) catalysed Grieco condensation: a facile approach for the synthesis of novel pyrimidine and annulated pyrimidine fused indazole derivatives in single pot under mild conditions and their anti-microbial activity.
2008 Feb
Synthesis and structure-activity relationships of a series of substituted 2-(1H-furo[2,3-g]indazol-1-yl)ethylamine derivatives as 5-HT2C receptor agonists.
2008 Feb 15
CYP2E1 substrate inhibition. Mechanistic interpretation through an effector site for monocyclic compounds.
2008 Feb 8
7-fluoroindazoles as potent and selective inhibitors of factor Xa.
2008 Jan 24
Patents
Substance Class Chemical
Created
by admin
on Fri Dec 15 19:51:37 GMT 2023
Edited
by admin
on Fri Dec 15 19:51:37 GMT 2023
Record UNII
7C4VQE5C03
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
INDAZOLE
Systematic Name English
BENZOPYRAZOLE
Systematic Name English
ISOINDAZOLE
Common Name English
NSC-26336
Code English
1H-INDAZOLE
MI  
Systematic Name English
1H-INDAZOLE [MI]
Common Name English
Code System Code Type Description
FDA UNII
7C4VQE5C03
Created by admin on Fri Dec 15 19:51:37 GMT 2023 , Edited by admin on Fri Dec 15 19:51:37 GMT 2023
PRIMARY
ECHA (EC/EINECS)
205-978-4
Created by admin on Fri Dec 15 19:51:37 GMT 2023 , Edited by admin on Fri Dec 15 19:51:37 GMT 2023
PRIMARY
MERCK INDEX
m6246
Created by admin on Fri Dec 15 19:51:37 GMT 2023 , Edited by admin on Fri Dec 15 19:51:37 GMT 2023
PRIMARY Merck Index
CAS
271-44-3
Created by admin on Fri Dec 15 19:51:37 GMT 2023 , Edited by admin on Fri Dec 15 19:51:37 GMT 2023
PRIMARY
PUBCHEM
9221
Created by admin on Fri Dec 15 19:51:37 GMT 2023 , Edited by admin on Fri Dec 15 19:51:37 GMT 2023
PRIMARY
EPA CompTox
DTXSID4075374
Created by admin on Fri Dec 15 19:51:37 GMT 2023 , Edited by admin on Fri Dec 15 19:51:37 GMT 2023
PRIMARY
CHEBI
36669
Created by admin on Fri Dec 15 19:51:37 GMT 2023 , Edited by admin on Fri Dec 15 19:51:37 GMT 2023
PRIMARY
NSC
26336
Created by admin on Fri Dec 15 19:51:37 GMT 2023 , Edited by admin on Fri Dec 15 19:51:37 GMT 2023
PRIMARY
WIKIPEDIA
INDAZOLE
Created by admin on Fri Dec 15 19:51:37 GMT 2023 , Edited by admin on Fri Dec 15 19:51:37 GMT 2023
PRIMARY
CHEBI
36671
Created by admin on Fri Dec 15 19:51:37 GMT 2023 , Edited by admin on Fri Dec 15 19:51:37 GMT 2023
PRIMARY