N-(6-AMINOHEXYL)-1-NAPHTHALENESULFONAMIDE

NCCCCCCNS(=O)(=O)C1=C2C=CC=CC2=CC=C1

InChIKey=FVJRBJIENDRNBE-UHFFFAOYSA-N

InChI=1S/C16H22N2O2S/c17-12-5-1-2-6-13-18-21(19,20)16-11-7-9-14-8-3-4-10-15(14)16/h3-4,7-11,18H,1-2,5-6,12-13,17H2

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Targets

Primary Target	Pharmacology	Condition	Potency
Phosphodiesterase 1 12 Target ID: CHEMBL2095150 Sources: https://www.ncbi.nlm.nih.gov/pubmed/6945588	Inhibitor 8297

PubMed

Title	Date	PubMed
Antagonists of calcium fluxes and calmodulin block activation of the p21-activated protein kinases in neutrophils.	2001 Feb 15	11160327
Calmodulin and calmodulin-dependent kinase II mediate neuronal cell death induced by depolarization.	2003 Feb 7	12543454
Calmodulin regulates transglutaminase 2 cross-linking of huntingtin.	2004 Feb 25	14985437
Ca(2+) and calmodulin modulate DNA-binding activity of maize heat shock transcription factor in vitro.	2004 May	15169945
Phosphorylation of dystrophin Dp71d by Ca2+/calmodulin-dependent protein kinase II modulates the Dp71d nuclear localization in PC12 cells.	2006 Aug	16893417
[Regulatory calcium effect on adenylyl cyclase functional activity in the infusorian Dileptus anser].	2007 Mar-Apr	17674704
[Functional characteristics of calcium-sensitive adenylyl cyclase of ciliate Tetrahymena pyriformis].	2010	21268858
Neuroprotective effects of calmodulin peptide 76-121aa: disruption of calmodulin binding to mutant huntingtin.	2010 Jan	19338577

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:45:53 GMT 2023` Edited by `admin` on `Fri Dec 15 17:45:53 GMT 2023`
Record UNII	7B979CWO03
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

N-(6-AMINOHEXYL)-1-NAPHTHALENESULFONAMIDE

Systematic Name

English

AMINOHEXYL)-1-NAPTHALENESULFONAMIDE, N-(6-

Common Name

English

Code System Code Type Description

FDA UNII

7B979CWO03

Created by admin on Fri Dec 15 17:45:53 GMT 2023 , Edited by admin on Fri Dec 15 17:45:53 GMT 2023

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PUBCHEM

4314

Created by admin on Fri Dec 15 17:45:53 GMT 2023 , Edited by admin on Fri Dec 15 17:45:53 GMT 2023

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CAS

79458-81-4

Created by admin on Fri Dec 15 17:45:53 GMT 2023 , Edited by admin on Fri Dec 15 17:45:53 GMT 2023

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EPA CompTox

DTXSID301000494

Created by admin on Fri Dec 15 17:45:53 GMT 2023 , Edited by admin on Fri Dec 15 17:45:53 GMT 2023

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