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Details

Stereochemistry RACEMIC
Molecular Formula C13H19N5.H2O
Molecular Weight 263.3387
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of PINACIDIL

SMILES

O.CC(NC(NC1=CC=NC=C1)=NC#N)C(C)(C)C

InChI

InChIKey=AFJCNBBHEVLGCZ-UHFFFAOYSA-N
InChI=1S/C13H19N5.H2O/c1-10(13(2,3)4)17-12(16-9-14)18-11-5-7-15-8-6-11;/h5-8,10H,1-4H3,(H2,15,16,17,18);1H2

HIDE SMILES / InChI

Molecular Formula C13H19N5
Molecular Weight 245.3235
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 1
Optical Activity ( + / - )

Molecular Formula H2O
Molecular Weight 18.0153
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Pinacidil is a clinically effective vasodilator used for the treatment of hypertension.

CNS Activity

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency
2.0 µM [EC50]
260.0 µM [EC50]

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
PINDAC

Cmax

ValueDoseCo-administeredAnalytePopulation
69.7 ng/mL
12.5 mg 2 times / day multiple, oral
PINACIDIL plasma
Homo sapiens

AUC

ValueDoseCo-administeredAnalytePopulation
365.4 ng × h/mL
12.5 mg 2 times / day multiple, oral
PINACIDIL plasma
Homo sapiens

T1/2

ValueDoseCo-administeredAnalytePopulation
10.7 h
12.5 mg 2 times / day multiple, oral
PINACIDIL plasma
Homo sapiens

Doses

AEs

Overview

OverviewOther

Other InhibitorOther SubstrateOther Inducer






Drug as victim

PubMed

Patents

Sample Use Guides

In Vivo Use Guide
Adults: Oral: 12.5 mg twice daily, may increase at intervals of 1-2 weeks; maximum dose: 100-150 mg/day in divided doses
Route of Administration: Oral
In Vitro Use Guide
In murine WT ventricular cells, pinacidil (1-100uM) concentration-dependently induced an outward current and action potential shortening, effects that were blocked by glibenclamide, a K(ATP) channel blocker.
Substance Class Chemical
Record UNII
7B0ZZH8P2W
Record Status Validated (UNII)
Record Version