IBERDOMIDE HYDROCHLORIDE

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C25H27N3O5.ClH
Molecular Weight	485.96
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.O=C1N(CC2=C1C=CC=C2OCC3=CC=C(CN4CCOCC4)C=C3)[C@H]5CCC(=O)NC5=O

InChI

InChIKey=VVHQVXXPZDALDV-BOXHHOBZSA-N

InChI=1S/C25H27N3O5.ClH/c29-23-9-8-21(24(30)26-23)28-15-20-19(25(28)31)2-1-3-22(20)33-16-18-6-4-17(5-7-18)14-27-10-12-32-13-11-27;/h1-7,21H,8-16H2,(H,26,29,30);1H/t21-;/m0./s1

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C25H27N3O5
Molecular Weight	449.499
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/28425720 | https://www.ncbi.nlm.nih.gov/pubmed/28848067 | https://www.ncbi.nlm.nih.gov/pubmed/29945920

CC-220 is a potent cereblon modulating agent that displays anti-proliferative, pro-apoptotic and immunomodulatory activity on sensitive and resistant multiple myeloma cell lines. CC-220 is currently under clinical investigation for systemic lupus erythematosus and multiple myeloma as a single agent, or in combination with dexamethasone in patients who may have previously been exposed to pomalidomide. Comparable to other Cereblon-binding agents, ex vivo treatment of CC-220 on B-cells, T-cells, and monocytes leads to the degradation of the hematopoietic transcription factors Ikaros (IKZF1) and Aiolos (IKZF3). followed by disruption of the multiple myeloma promoting c-Myc/IRF4 axis.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Protein cereblon 10 Target ID: Q96SW2 Gene ID: 51185.0 Gene Symbol: CRBN Target Organism: Homo sapiens (Human) Sources: http://www.bloodjournal.org/content/128/22/1591	Binding Agent 1076

C_max

Value	Dose	Analyte	Population
3.34 ng/mL EXPERIMENT https://www.tandfonline.com/doi/epdf/10.2147/CPAA.S397826?needAccess=true&role=button	1 mg single, oral dose: 1 mg route of administration: Oral experiment type: SINGLE co-administered:	CC-220 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
2.61 ng/mL EXPERIMENT https://www.tandfonline.com/doi/epdf/10.2147/CPAA.S397826?needAccess=true&role=button	1 mg single, oral dose: 1 mg route of administration: Oral experiment type: SINGLE co-administered:	CC-220 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
3.06 ng/mL EXPERIMENT https://www.tandfonline.com/doi/epdf/10.2147/CPAA.S397826?needAccess=true&role=button	1 mg single, oral dose: 1 mg route of administration: Oral experiment type: SINGLE co-administered:	CC-220 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
3.62 ng/mL EXPERIMENT https://www.tandfonline.com/doi/epdf/10.2147/CPAA.S397826?needAccess=true&role=button	1 mg single, oral dose: 1 mg route of administration: Oral experiment type: SINGLE co-administered:	CC-220 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
2.85 ng/mL EXPERIMENT https://www.tandfonline.com/doi/epdf/10.2147/CPAA.S397826?needAccess=true&role=button	1 mg single, oral dose: 1 mg route of administration: Oral experiment type: SINGLE co-administered:	CC-220 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
0.3 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/32969202/	0.1 mg single, oral dose: 0.1 mg route of administration: Oral experiment type: SINGLE co-administered:	CC-220 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
0.7 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/32969202/	0.3 mg single, oral dose: 0.3 mg route of administration: Oral experiment type: SINGLE co-administered:	CC-220 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
2.7 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/32969202/	1 mg single, oral dose: 1 mg route of administration: Oral experiment type: SINGLE co-administered:	CC-220 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
4.8 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/32969202/	2 mg single, oral dose: 2 mg route of administration: Oral experiment type: SINGLE co-administered:	CC-220 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
10.1 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/32969202/	4 mg single, oral dose: 4 mg route of administration: Oral experiment type: SINGLE co-administered:	CC-220 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
17.7 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/32969202/	6 mg single, oral dose: 6 mg route of administration: Oral experiment type: SINGLE co-administered:	CC-220 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
2.2 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/32969202/	1 mg single, oral dose: 1 mg route of administration: Oral experiment type: SINGLE co-administered:	CC-220 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FED
2.3 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/32969202/	1 mg single, oral dose: 1 mg route of administration: Oral experiment type: SINGLE co-administered:	CC-220 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED

AUC

Value	Dose	Analyte	Population
52.8 ng × h/mL EXPERIMENT https://www.tandfonline.com/doi/epdf/10.2147/CPAA.S397826?needAccess=true&role=button	1 mg single, oral dose: 1 mg route of administration: Oral experiment type: SINGLE co-administered:	CC-220 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
41.9 ng × h/mL EXPERIMENT https://www.tandfonline.com/doi/epdf/10.2147/CPAA.S397826?needAccess=true&role=button	1 mg single, oral dose: 1 mg route of administration: Oral experiment type: SINGLE co-administered:	CC-220 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
49.3 ng × h/mL EXPERIMENT https://www.tandfonline.com/doi/epdf/10.2147/CPAA.S397826?needAccess=true&role=button	1 mg single, oral dose: 1 mg route of administration: Oral experiment type: SINGLE co-administered:	CC-220 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
45.4 ng × h/mL EXPERIMENT https://www.tandfonline.com/doi/epdf/10.2147/CPAA.S397826?needAccess=true&role=button	1 mg single, oral dose: 1 mg route of administration: Oral experiment type: SINGLE co-administered:	CC-220 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
43.2 ng × h/mL EXPERIMENT https://www.tandfonline.com/doi/epdf/10.2147/CPAA.S397826?needAccess=true&role=button	1 mg single, oral dose: 1 mg route of administration: Oral experiment type: SINGLE co-administered:	CC-220 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
4.9 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/32969202/	0.1 mg single, oral dose: 0.1 mg route of administration: Oral experiment type: SINGLE co-administered:	CC-220 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
9.8 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/32969202/	0.3 mg single, oral dose: 0.3 mg route of administration: Oral experiment type: SINGLE co-administered:	CC-220 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
45 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/32969202/	1 mg single, oral dose: 1 mg route of administration: Oral experiment type: SINGLE co-administered:	CC-220 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
78.2 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/32969202/	2 mg single, oral dose: 2 mg route of administration: Oral experiment type: SINGLE co-administered:	CC-220 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
153.3 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/32969202/	4 mg single, oral dose: 4 mg route of administration: Oral experiment type: SINGLE co-administered:	CC-220 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
255.1 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/32969202/	6 mg single, oral dose: 6 mg route of administration: Oral experiment type: SINGLE co-administered:	CC-220 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
40.4 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/32969202/	1 mg single, oral dose: 1 mg route of administration: Oral experiment type: SINGLE co-administered:	CC-220 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FED
38.7 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/32969202/	1 mg single, oral dose: 1 mg route of administration: Oral experiment type: SINGLE co-administered:	CC-220 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED

T_1/2

Value	Dose	Analyte	Population
17.4 h EXPERIMENT https://www.tandfonline.com/doi/epdf/10.2147/CPAA.S397826?needAccess=true&role=button	1 mg single, oral dose: 1 mg route of administration: Oral experiment type: SINGLE co-administered:	CC-220 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
14.3 h EXPERIMENT https://www.tandfonline.com/doi/epdf/10.2147/CPAA.S397826?needAccess=true&role=button	1 mg single, oral dose: 1 mg route of administration: Oral experiment type: SINGLE co-administered:	CC-220 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
17 h EXPERIMENT https://www.tandfonline.com/doi/epdf/10.2147/CPAA.S397826?needAccess=true&role=button	1 mg single, oral dose: 1 mg route of administration: Oral experiment type: SINGLE co-administered:	CC-220 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
17 h EXPERIMENT https://www.tandfonline.com/doi/epdf/10.2147/CPAA.S397826?needAccess=true&role=button	1 mg single, oral dose: 1 mg route of administration: Oral experiment type: SINGLE co-administered:	CC-220 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
15.3 h EXPERIMENT https://www.tandfonline.com/doi/epdf/10.2147/CPAA.S397826?needAccess=true&role=button	1 mg single, oral dose: 1 mg route of administration: Oral experiment type: SINGLE co-administered:	CC-220 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
11.2 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/32969202/	0.1 mg single, oral dose: 0.1 mg route of administration: Oral experiment type: SINGLE co-administered:	CC-220 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
8.8 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/32969202/	0.3 mg single, oral dose: 0.3 mg route of administration: Oral experiment type: SINGLE co-administered:	CC-220 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
13.2 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/32969202/	1 mg single, oral dose: 1 mg route of administration: Oral experiment type: SINGLE co-administered:	CC-220 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
13.4 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/32969202/	2 mg single, oral dose: 2 mg route of administration: Oral experiment type: SINGLE co-administered:	CC-220 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
12.1 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/32969202/	4 mg single, oral dose: 4 mg route of administration: Oral experiment type: SINGLE co-administered:	CC-220 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
17.7 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/32969202/	6 mg single, oral dose: 6 mg route of administration: Oral experiment type: SINGLE co-administered:	CC-220 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
11.8 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/32969202/	1 mg single, oral dose: 1 mg route of administration: Oral experiment type: SINGLE co-administered:	CC-220 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FED
13.7 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/32969202/	1 mg single, oral dose: 1 mg route of administration: Oral experiment type: SINGLE co-administered:	CC-220 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED

F_unbound

Value	Dose	Co-administered	Analyte	Population
32% EXPERIMENT https://www.tandfonline.com/doi/epdf/10.2147/CPAA.S397826?needAccess=true&role=button	single, unknown		CC-220 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

PubMed

Title	Date	PubMed
Aiolos Overexpression in Systemic Lupus Erythematosus B Cell Subtypes and BAFF-Induced Memory B Cell Differentiation Are Reduced by CC-220 Modulation of Cereblon Activity.	2017-10-01	28848067

Patents

Sample Use Guides

In Vivo Use Guide

0.3 mg for 21 days of a 28-day cycle

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:19:18 GMT 2025` Edited by `admin` on `Mon Mar 31 18:19:18 GMT 2025`
Record UNII	79L3645KFI
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CC-220 HYDROCHLORIDE

Preferred Name

English

IBERDOMIDE HYDROCHLORIDE

Official Name

English

Iberdomide hydrochloride [WHO-DD]

Common Name

English

2,6-PIPERIDINEDIONE, 3-(1,3-DIHYDRO-4-((4-(4-MORPHOLINYLMETHYL)PHENYL)METHOXY)-1-OXO-2H-ISOINDOL-2-YL)-, HYDROCHLORIDE (1:1), (3S)-

Systematic Name

English

IBERDOMIDE HYDROCHLORIDE [USAN]

Common Name

English

(3S)-3-[4-({4-[(Morpholin-4-yl)methyl]phenyl}methoxy)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione monohydrochloride

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C308