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Details

Stereochemistry ABSOLUTE
Molecular Formula C25H27N3O5.ClH
Molecular Weight 485.96
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of IBERDOMIDE HYDROCHLORIDE

SMILES

Cl.O=C1N(CC2=C1C=CC=C2OCC3=CC=C(CN4CCOCC4)C=C3)[C@H]5CCC(=O)NC5=O

InChI

InChIKey=VVHQVXXPZDALDV-BOXHHOBZSA-N
InChI=1S/C25H27N3O5.ClH/c29-23-9-8-21(24(30)26-23)28-15-20-19(25(28)31)2-1-3-22(20)33-16-18-6-4-17(5-7-18)14-27-10-12-32-13-11-27;/h1-7,21H,8-16H2,(H,26,29,30);1H/t21-;/m0./s1

HIDE SMILES / InChI

Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C25H27N3O5
Molecular Weight 449.499
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

CC-220 is a potent cereblon modulating agent that displays anti-proliferative, pro-apoptotic and immunomodulatory activity on sensitive and resistant multiple myeloma cell lines. CC-220 is currently under clinical investigation for systemic lupus erythematosus and multiple myeloma as a single agent, or in combination with dexamethasone in patients who may have previously been exposed to pomalidomide. Comparable to other Cereblon-binding agents, ex vivo treatment of CC-220 on B-cells, T-cells, and monocytes leads to the degradation of the hematopoietic transcription factors Ikaros (IKZF1) and Aiolos (IKZF3). followed by disruption of the multiple myeloma promoting c-Myc/IRF4 axis.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: Q96SW2
Gene ID: 51185.0
Gene Symbol: CRBN
Target Organism: Homo sapiens (Human)
PubMed

PubMed

TitleDatePubMed
Aiolos Overexpression in Systemic Lupus Erythematosus B Cell Subtypes and BAFF-Induced Memory B Cell Differentiation Are Reduced by CC-220 Modulation of Cereblon Activity.
2017 Oct 1
Patents

Patents

Sample Use Guides

0.3 mg for 21 days of a 28-day cycle
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:06:43 GMT 2023
Edited
by admin
on Fri Dec 15 16:06:43 GMT 2023
Record UNII
79L3645KFI
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
IBERDOMIDE HYDROCHLORIDE
USAN  
USAN  
Official Name English
CC-220 HYDROCHLORIDE
Common Name English
Iberdomide hydrochloride [WHO-DD]
Common Name English
2,6-PIPERIDINEDIONE, 3-(1,3-DIHYDRO-4-((4-(4-MORPHOLINYLMETHYL)PHENYL)METHOXY)-1-OXO-2H-ISOINDOL-2-YL)-, HYDROCHLORIDE (1:1), (3S)-
Systematic Name English
IBERDOMIDE HYDROCHLORIDE [USAN]
Common Name English
(3S)-3-[4-({4-[(Morpholin-4-yl)methyl]phenyl}methoxy)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione monohydrochloride
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C308
Created by admin on Fri Dec 15 16:06:43 GMT 2023 , Edited by admin on Fri Dec 15 16:06:43 GMT 2023
Code System Code Type Description
PUBCHEM
72793904
Created by admin on Fri Dec 15 16:06:43 GMT 2023 , Edited by admin on Fri Dec 15 16:06:43 GMT 2023
PRIMARY
SMS_ID
300000044588
Created by admin on Fri Dec 15 16:06:43 GMT 2023 , Edited by admin on Fri Dec 15 16:06:43 GMT 2023
PRIMARY
USAN
DE-07
Created by admin on Fri Dec 15 16:06:43 GMT 2023 , Edited by admin on Fri Dec 15 16:06:43 GMT 2023
PRIMARY
CAS
1560678-63-8
Created by admin on Fri Dec 15 16:06:43 GMT 2023 , Edited by admin on Fri Dec 15 16:06:43 GMT 2023
PRIMARY
NCI_THESAURUS
C141516
Created by admin on Fri Dec 15 16:06:43 GMT 2023 , Edited by admin on Fri Dec 15 16:06:43 GMT 2023
PRIMARY
CAS
1560608-91-4
Created by admin on Fri Dec 15 16:06:43 GMT 2023 , Edited by admin on Fri Dec 15 16:06:43 GMT 2023
NON-SPECIFIC STOICHIOMETRY
FDA UNII
79L3645KFI
Created by admin on Fri Dec 15 16:06:43 GMT 2023 , Edited by admin on Fri Dec 15 16:06:43 GMT 2023
PRIMARY
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