TISOPURINE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C5H4N4S
Molecular Weight	152.177
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of TISOPURINE

Structure Search

SMILES

S=C1N=CNC2=C1C=NN2

InChI

InChIKey=PYAOPMWCFSVFOT-UHFFFAOYSA-N

InChI=1S/C5H4N4S/c10-5-3-1-8-9-4(3)6-2-7-5/h1-2H,(H2,6,7,8,9,10)

HIDE SMILES / InChI

Molecular Formula	C5H4N4S
Molecular Weight	152.177
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/22454898 | https://www.ncbi.nlm.nih.gov/pubmed/9208004

Tisopurine (or Thiopurinol) was used in the treatment of gout. This drug reduces uric acid concentrations by interfering with the early stages of its synthesis, thus avoiding increased blood concentrations of hypoxanthine and xanthine. In addition, it was discovered, that tisopurine caused acute hepatitis.

Approval Year

Targets

Targets

Primary Target	Pharmacology	Condition	Potency
Uric acid 1 Target ID: CHEMBL2364183 Sources: https://www.ncbi.nlm.nih.gov/pubmed/8178077	Inhibitor 8297
platelet aggregation 76 Target ID: GO:0070527 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2551060	Inhibitor 8297
Leishmania donovani 13 Target ID: CHEMBL367 Sources: https://www.ncbi.nlm.nih.gov/pubmed/3992630 \| https://www.ncbi.nlm.nih.gov/pubmed/2424909	Inhibitor 8297

PubMed

PubMed

Title	Date	PubMed
Biochemical characterization of some pyrazolopyrimidine-based inhibitors of xanthine oxidase.	2006	16487068

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:11:31 GMT 2023` Edited by `admin` on `Fri Dec 15 16:11:31 GMT 2023`
Record UNII	79F9I2R16M
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

TISOPURINE

Official Name

English

EXURACID

Brand Name

English

NSC-1392

Code

English

1H-PYRAZOLO(3,4-D)PYRIMIDINE-4-THIOL

Systematic Name

English

TISOPURINE [MART.]

Common Name

English

tisopurine [INN]

Common Name

English

Tisopurine [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C921

Created by admin on Fri Dec 15 16:11:31 GMT 2023 , Edited by admin on Fri Dec 15 16:11:31 GMT 2023

NCI_THESAURUS

C1637

Created by admin on Fri Dec 15 16:11:31 GMT 2023 , Edited by admin on Fri Dec 15 16:11:31 GMT 2023

WHO-VATC

QM04AA02

Created by admin on Fri Dec 15 16:11:31 GMT 2023 , Edited by admin on Fri Dec 15 16:11:31 GMT 2023

WHO-ATC

M04AA02

Created by admin on Fri Dec 15 16:11:31 GMT 2023 , Edited by admin on Fri Dec 15 16:11:31 GMT 2023

Code System Code Type Description

WIKIPEDIA

TISOPURINE

Created by admin on Fri Dec 15 16:11:31 GMT 2023 , Edited by admin on Fri Dec 15 16:11:31 GMT 2023

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DRUG CENTRAL

2682

Created by admin on Fri Dec 15 16:11:31 GMT 2023 , Edited by admin on Fri Dec 15 16:11:31 GMT 2023

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ChEMBL

CHEMBL119423

Created by admin on Fri Dec 15 16:11:31 GMT 2023 , Edited by admin on Fri Dec 15 16:11:31 GMT 2023

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ECHA (EC/EINECS)

226-251-8

Created by admin on Fri Dec 15 16:11:31 GMT 2023 , Edited by admin on Fri Dec 15 16:11:31 GMT 2023

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SMS_ID

100000082119

Created by admin on Fri Dec 15 16:11:31 GMT 2023 , Edited by admin on Fri Dec 15 16:11:31 GMT 2023

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PUBCHEM

135445058

Created by admin on Fri Dec 15 16:11:31 GMT 2023 , Edited by admin on Fri Dec 15 16:11:31 GMT 2023

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DRUG BANK

DB13807

Created by admin on Fri Dec 15 16:11:31 GMT 2023 , Edited by admin on Fri Dec 15 16:11:31 GMT 2023

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NSC

1392

Created by admin on Fri Dec 15 16:11:31 GMT 2023 , Edited by admin on Fri Dec 15 16:11:31 GMT 2023

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RXCUI

38136

Created by admin on Fri Dec 15 16:11:31 GMT 2023 , Edited by admin on Fri Dec 15 16:11:31 GMT 2023

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RxNorm

EPA CompTox

DTXSID90201488

Created by admin on Fri Dec 15 16:11:31 GMT 2023 , Edited by admin on Fri Dec 15 16:11:31 GMT 2023

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CAS

5334-23-6

Created by admin on Fri Dec 15 16:11:31 GMT 2023 , Edited by admin on Fri Dec 15 16:11:31 GMT 2023

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EVMPD

SUB11121MIG

Created by admin on Fri Dec 15 16:11:31 GMT 2023 , Edited by admin on Fri Dec 15 16:11:31 GMT 2023

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NCI_THESAURUS

C80872

Created by admin on Fri Dec 15 16:11:31 GMT 2023 , Edited by admin on Fri Dec 15 16:11:31 GMT 2023

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MESH

C005832

Created by admin on Fri Dec 15 16:11:31 GMT 2023 , Edited by admin on Fri Dec 15 16:11:31 GMT 2023

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INN

3842

Created by admin on Fri Dec 15 16:11:31 GMT 2023 , Edited by admin on Fri Dec 15 16:11:31 GMT 2023

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FDA UNII

79F9I2R16M

Created by admin on Fri Dec 15 16:11:31 GMT 2023 , Edited by admin on Fri Dec 15 16:11:31 GMT 2023

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Related Record Type Details


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