VM4-037 F-18

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C26H29FN6O7S2
Molecular Weight	619.675
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)[C@H](N1C=C(COC2=CC=C3N=C(SC3=C2)S(N)(=O)=O)N=N1)C(=O)N[C@@H](CC4=CC=C(OCC[18F])C=C4)C(O)=O

InChI

InChIKey=QGYZPMXIVNIGKA-SZJJUGPPSA-N

InChI=1S/C26H29FN6O7S2/c1-15(2)23(24(34)29-21(25(35)36)11-16-3-5-18(6-4-16)39-10-9-27)33-13-17(31-32-33)14-40-19-7-8-20-22(12-19)41-26(30-20)42(28,37)38/h3-8,12-13,15,21,23H,9-11,14H2,1-2H3,(H,29,34)(H,35,36)(H2,28,37,38)/t21-,23-/m0/s1/i27-1

HIDE SMILES / InChI

Molecular Formula	C26H29FN6O7S2
Molecular Weight	619.675
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 19:51:01 GMT 2023` Edited by `admin` on `Fri Dec 15 19:51:01 GMT 2023`
Record UNII	78YP9ZU8U6
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

VM4-037 F-18

Common Name

English

(S)-3-(4-(2-(F-18)FLUOROETHOXY)PHENYL)-2-((S)-3-METHYL-2-(4-((2-SULFAMOYLBENZO(D)THIAZOL-6-YLOXY)METHYL)-1H-1,2,3-TRIAZOL-1-YL)BUTANAMIDO)PROPANOIC ACID

Common Name

English

L-TYROSINE, N-((2S)-2-(4-(((2-(AMINOSULFONYL)-6-BENZOTHIAZOLYL)OXY)METHYL)-1H-1,2,3-TRIAZOL-1-YL)-3-METHYL-1-OXOBUTYL)-O-(2-(FLUORO-18F)ETHYL)-

Common Name

English

(18F)VM-4-037

Code

English

(F18)VM-4-037

Code

English

Code System Code Type Description

PUBCHEM

59552685

Created by admin on Fri Dec 15 19:51:01 GMT 2023 , Edited by admin on Fri Dec 15 19:51:01 GMT 2023

PRIMARY

CAS

1071471-25-4

Created by admin on Fri Dec 15 19:51:01 GMT 2023 , Edited by admin on Fri Dec 15 19:51:01 GMT 2023

PRIMARY

FDA UNII

78YP9ZU8U6

Created by admin on Fri Dec 15 19:51:01 GMT 2023 , Edited by admin on Fri Dec 15 19:51:01 GMT 2023

PRIMARY

Related Record Type Details


					78YP9ZU8U6

VM4-037 F-18

ACTIVE MOIETY

Comments:

Results: MicroPET imaging showed high (18F)VM4-037 uptake in the abdominal region, and biodistribution revealed high radioactivity in the kidney, ileum, colon, liver, stomach, and bladder. Although high CAIX expression was confirmed in both tumor models, tumor uptake assessed with microPET and biodistribution experiments was comparable to background tissues. Conclusions: In this study, (18F)VM4-037 does not specifically accumulate in CAIX-expressing tumors, indicating that the tracer is not suitable for the detection of CAIX.