Eclutatug

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NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 17:08:59 GMT 2025` Edited by `admin` on `Wed Apr 02 17:08:59 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1\|KAPPA
Sequence Origin	HUMANIZED RAT
Sequence Type	COMPLETE
Record UNII	78938RG6AM
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Eclutatug

Official Name

English

ALE.C04

Preferred Name

English

Immunoglobulin G1 [de-C-terminal-lysine], anti-(human claudin-1) (human-Rattus norvegicus monoclonal ALE.C04 allotype G1m(3) ?1-chain), disulfide with human-Rattus norvegicus monoclonal ALE.C04 ?-chain, dimer

Common Name

English

H-gamma1 heavy chain humanized (1-448) [VH (Homo sapiens IGHV3-21*01 (94.9%) -(IGHD) -IGHJ1*01 (92.9%), CDR-IMGT [8.8.12] (26-33.51-58.97-108)) (1-119) -Homo sapiens IGHG1*03 (100%) G1m3, nG1m1 CH1 R120, CH3 E12, M14 (CH1 R120 (216) (120-217), hinge 1-15

Common Name

English

eclutatug [INN]

Common Name

English

immunoglobulin G1-kappa, anti-[Homo sapiens sapiens CLDN1 (claudin-1) conformational epitope of the first extracellular loop (EL1)], humanized monoclonal antibody

Common Name

English

Code System Code Type Description

SMS_ID

300000051308

Created by admin on Wed Apr 02 17:08:59 GMT 2025 , Edited by admin on Wed Apr 02 17:08:59 GMT 2025

PRIMARY

CAS

2922054-25-7

Created by admin on Wed Apr 02 17:08:59 GMT 2025 , Edited by admin on Wed Apr 02 17:08:59 GMT 2025

PRIMARY

NCI_THESAURUS

C201755

Created by admin on Wed Apr 02 17:08:59 GMT 2025 , Edited by admin on Wed Apr 02 17:08:59 GMT 2025

PRIMARY

INN

13184

Created by admin on Wed Apr 02 17:08:59 GMT 2025 , Edited by admin on Wed Apr 02 17:08:59 GMT 2025

PRIMARY

FDA UNII

78938RG6AM

Created by admin on Wed Apr 02 17:08:59 GMT 2025 , Edited by admin on Wed Apr 02 17:08:59 GMT 2025

PRIMARY

From	To
1_22	1_96
2_22	2_96
2_146	2_202
2_222	4_214
2_263	2_323
1_146	1_202
2_369	2_427
3_23	3_88
3_134	3_194
4_23	4_88
4_134	4_194
1_222	3_214
1_228	2_228
1_231	2_231
1_263	1_323
1_369	1_427

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_299
N	2_299

Related Record Type Details


					78938RG6AM

Eclutatug

ACTIVE MOIETY

Comments:

ALE.C04 was shown to induce antibody-dependent cellular cytotoxicity (ADCC; primary mode of action), antibody-dependent cellular phagocytosis (ADCP), and complement-dependent cytotoxicity (CDC) activity against CLDN1 expressed in HNSCC.

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_447] [2_447]	C-TERMINUS	P		PROLINAMIDE	VD6PQK9DHG
AMINO ACID REMOVAL	[1_448] [2_448]	C-TERMINUS	G		Glycine	TE7660XO1C
AMINO_ACID_SUBSTITUTION		N-TERMINUS	Q	Amount:	PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL