Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | CH2F2 |
| Molecular Weight | 52.0234 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
FCF
InChI
InChIKey=RWRIWBAIICGTTQ-UHFFFAOYSA-N
InChI=1S/CH2F2/c2-1-3/h1H2
| Molecular Formula | CH2F2 |
| Molecular Weight | 52.0234 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Mechanism and dynamic correlation effects in cycloaddition reactions of singlet difluorocarbene to alkenes and disilene. | 2009-09-10 |
|
| Flexible synthesis of pyrimidines with chiral monofluorinated and difluoromethyl side chains. | 2009-06-19 |
|
| Estimations of global warming potentials from computational chemistry calculations for CH(2)F(2) and other fluorinated methyl species verified by comparison to experiment. | 2009-05-21 |
|
| N-Tosyl-S-difluoromethyl-S-phenylsulfoximine: a new difluoromethylation reagent for S-, N-, and C-nucleophiles. | 2009-05-21 |
|
| Solubilization of n-alkylbenzene and n-perfluoroalkylbenzene in hydrogenated and fluorinated surfactants micelles. | 2009-05-15 |
|
| A perfect double role of CF3 groups in activating substrates and stabilizing adducts: the chiral Brønsted acid-catalyzed direct arylation of trifluoromethyl ketones. | 2009-05-07 |
|
| Modeling kinetics of subcellular disposition of chemicals. | 2009-05 |
|
| A new synthesis of difluorodiazirine and the absolute reactivity of difluorocarbene. | 2009-02-18 |
|
| Synthesis and conformational analysis of (alpha-D-galactosyl)phenylmethane and alpha-,beta-difluoromethane analogues: interactions with the plant lectin viscumin. | 2009 |
|
| Design, synthesis, and structure-activity relationship, molecular modeling, and NMR studies of a series of phenyl alkyl ketones as highly potent and selective phosphodiesterase-4 inhibitors. | 2008-12-25 |
|
| Dimers of fluorinated methanes with carbonyl sulfide: the rotational spectrum and structure of difluoromethane-OCS. | 2008-12-11 |
|
| Enantioselective organocatalyzed Henry reaction with fluoromethyl ketones. | 2008-09-28 |
|
| Second-generation difluorinated cyclooctynes for copper-free click chemistry. | 2008-08-27 |
|
| Electron transfer reactions for image and image-derived states in dielectric thin films. | 2008-08-21 |
|
| Burning velocity measurements of nitrogen-containing compounds. | 2008-06-30 |
|
| Applying stable isotope probing of phospholipid fatty acids and rRNA in a Chinese rice field to study activity and composition of the methanotrophic bacterial communities in situ. | 2008-06 |
|
| Boron-substituted difluorocyclopropanes: new building blocks of gem-difluorocyclopropanes. | 2008-03-06 |
|
| A new class of substrates for nucleophilic 5-endo-trig cyclization, 2-trifluoromethyl-1-alkenes: synthesis of five-membered hetero- and carbocycles that bear fluorinated one-carbon units. | 2008-02-01 |
|
| Activity and composition of methanotrophic bacterial communities in planted rice soil studied by flux measurements, analyses of pmoA gene and stable isotope probing of phospholipid fatty acids. | 2008-02 |
|
| Difluorocarbene studied with threshold photoelectron spectroscopy (TPES): measurement of the first adiabatic ionization energy (AIE) of CF(2). | 2008 |
|
| Role of biotransformation studies in minimizing metabolism-related liabilities in drug discovery. | 2008 |
|
| Chlorodifluoromethyl phenyl sulfone: a novel non-ozone-depleting substance-based difluorocarbene reagent for O- and N-difluoromethylations. | 2007-12-28 |
|
| Electronic properties of multifurcated bent hydrogen bonds CH3...Y and CH2...Y. | 2007-12-21 |
|
| Difluoromethyltrialkylammonium salts--their expeditious synthesis from chlorodifluoromethane and tertiary amines in the presence of concentrated aqueous sodium hydroxide. The catalytic process. | 2007-12-21 |
|
| Automatic generation of potential energy and property surfaces of polyatomic molecules in normal coordinates. | 2007-11-28 |
|
| Differential inhibition of class I and class II 5-enolpyruvylshikimate-3-phosphate synthases by tetrahedral reaction intermediate analogues. | 2007-11-20 |
|
| Hybrid density functional theory with a specific reaction parameter: hydrogen abstraction reaction of difluoromethane by the hydroxyl radical. | 2007-11 |
|
| Synthesis and conformational behavior of the difluoromethylene linked C-glycoside analog of beta-galactopyranosyl-(1<-->1)-alpha-mannopyranoside. | 2007-09-03 |
|
| Acid sphingomyelinase inhibition suppresses lipopolysaccharide-mediated release of inflammatory cytokines from macrophages and protects against disease pathology in dextran sulphate sodium-induced colitis in mice. | 2007-09 |
|
| Addition of difluoromethyl radicals to glycals: a new route to alpha-CF2-D-glycosides. | 2007-06-21 |
|
| Group 4 transition metal CH2=MF2, CHF=MF2, and HC/MF3 complexes formed by C-F activation and alpha-fluorine transfer. | 2007-06-11 |
|
| Electronegative oligothiophenes for n-type semiconductors: difluoromethylene-bridged bithiophene and its oligomers. | 2007-05-24 |
|
| New electrophilic difluoromethylating reagent. | 2007-05-10 |
|
| Synthesis of 3'-deoxynucleosides with 2-oxabicyclo[3.1.0]hexane sugar moieties: addition of difluorocarbene to a 3',4'-unsaturated uridine derivative and 1,2-dihydrofurans derived from D- and L-xylose1. | 2007-04-27 |
|
| Structures and large NLO responses of new electrides: Li-doped fluorocarbon chain. | 2007-03-14 |
|
| Shapes and noncovalent interactions of oligomers: the rotational spectrum of the difluoromethane trimer. | 2007-03-07 |
|
| Palladium-catalyzed cross-coupling reactions in c6 modifications of purine nucleosides. | 2007-03 |
|
| Difluoromethyl analogs of the natural hormone 1alpha,25-dihydroxyvitamin D3: Design, synthesis, and preliminary biological evaluation. | 2007-03 |
|
| Addition of difluorocarbene to 3',4'-unsaturated nucleosides: synthesis of 2'-deoxy analogues with a 2-oxabicyclo[3.1.0]hexane framework. | 2007-01-19 |
|
| Measurement of gas-accessible NAPL saturation in soil using gaseous tracers. | 2007-01-01 |
|
| Inhibition of lipopolysaccharide-induced release of interleukin-8 from intestinal epithelial cells by SMA, a novel inhibitor of sphingomyelinase and its therapeutic effect on dextran sulphate sodium-induced colitis in mice. | 2007-01 |
|
| 2-Chloro-2,2-difluoroacetophenone: a non-ODS-based difluorocarbene precursor and its use in the difluoromethylation of phenol derivatives. | 2006-12-22 |
|
| Synthesis of methylene- and difluoromethylenephosphonate analogues of uridine-4-phosphate and 3-deazauridine-4-phosphate. | 2006-12-08 |
|
| Addition of difluorocarbene to 4',5'-unsaturated nucleosides: synthesis and deoxygenation reactions of difluorospirocyclopropane nucleosides. | 2006-11-10 |
|
| Divergent chemical synthesis of prolines bearing fluorinated one-carbon units at the 4-position via nucleophilic 5-endo-trig cyclizations. | 2006-11-10 |
|
| Mapping the fluorophilicity of a hydrophobic pocket: synthesis and biological evaluation of tricyclic thrombin inhibitors directing fluorinated alkyl groups into the p pocket. | 2006-11 |
|
| Reaction of [Fe2(CO)8(mu-CF2)] with AsMe3 and other Lewis bases: syntheses, crystal structures of [Fe(CO)6(AsMe3)2(mu-CF2)] and [Fe(CO)5(AsMe3)3(mu-CF2)], and theoretical considerations. | 2006-10-30 |
|
| Generalized solvation heat capacities. | 2006-10-12 |
|
| Synthesis and evaluation of new difluoromethyl azoles as antileishmanial agents. | 2006-10-02 |
|
| Reaction-path dynamics and theoretical rate constants for the CH(n)F(4-n) + O3 --> HOOO + CH(n-1)F(4-n) (n = 2,3) reactions. | 2006-09-28 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 21:36:27 GMT 2025
by
admin
on
Mon Mar 31 21:36:27 GMT 2025
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| Record UNII |
77JW9K722X
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| Record Status |
Validated (UNII)
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| Record Version |
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CFR |
21 CFR 189.191
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admin on Mon Mar 31 21:36:27 GMT 2025 , Edited by admin on Mon Mar 31 21:36:27 GMT 2025
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