MK-8325

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C43H52F2N8O6Si.2ClH
Molecular Weight	915.927
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.Cl.COC(=O)N[C@@H](C(C)C)C(=O)N1CC(F)(F)C[C@H]1C2=NC(=CN2)C3=CC=C(C=C3)C4=CC5=CC=C6N=C(NC6=C5C=C4)[C@@H]7C[Si](C)(C)CN7C(=O)[C@@H](NC(=O)OC)C(C)C

InChI

InChIKey=IUEFJCXFZOOGJY-RYYFUXLTSA-N

InChI=1S/C43H52F2N8O6Si.2ClH/c1-23(2)34(50-41(56)58-5)39(54)52-21-43(44,45)18-32(52)37-46-19-31(48-37)26-11-9-25(10-12-26)27-13-15-29-28(17-27)14-16-30-36(29)49-38(47-30)33-20-60(7,8)22-53(33)40(55)35(24(3)4)51-42(57)59-6;;/h9-17,19,23-24,32-35H,18,20-22H2,1-8H3,(H,46,48)(H,47,49)(H,50,56)(H,51,57);2*1H/t32-,33-,34-,35-;;/m0../s1

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C43H52F2N8O6Si
Molecular Weight	843.0053
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/29653894 | https://www.ncbi.nlm.nih.gov/pubmed/27282743

MK-8325 is tricyclic silyl compound patented by Schering Corporation as an antiviral agent for treating hepatitis C virus infection. MK-8325 acts as a potent hepatitis C virus nonstructural protein 5A (NS5A) inhibitor with excellent replicon activity across multiple genotypes. The compound is orally absorbed from the GI tracts of rats, dogs, and cynomolgus monkeys with low to moderate bioavailability. MK-8325 showed high protein binding in all species and is highly distributed to the target organ with minimal or no brain distribution In vitro and in vivo assays showed MK-8325 to be orally bioavailable with pharmacokinetics suitable for once-daily dosing in patients and good overall ADME profiles.

Originator

Approval Year

PubMed

Title	Date	PubMed
MK-8325: A silyl proline-containing NS5A inhibitor with pan-genotype activity for treatment of HCV.	2018 Jun 1	29653894

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 12:05:01 GMT 2023` Edited by `admin` on `Sat Dec 16 12:05:01 GMT 2023`
Record UNII	779TT17O5A
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MK-8325

Common Name

English

Code System Code Type Description

SMS_ID

300000041467