METIAPINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H21N3S
Molecular Weight	323.455
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1CCN(CC1)C2=NC3=C(SC4=C2C=C(C)C=C4)C=CC=C3

InChI

InChIKey=IOEPXYJOHIZYGQ-UHFFFAOYSA-N

InChI=1S/C19H21N3S/c1-14-7-8-17-15(13-14)19(22-11-9-21(2)10-12-22)20-16-5-3-4-6-18(16)23-17/h3-8,13H,9-12H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C19H21N3S
Molecular Weight	323.455
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4198309 | https://www.ncbi.nlm.nih.gov/pubmed/28349512

Metiapine, a dibenzothiazepine derivative, possesses neuroleptic and antipsychotic properties. This drug was developed for the treatment of schizophrenia. However, the further development of this drug was stopped because of the presence of more effective drugs.

Approval Year

PubMed

Title	Date	PubMed
Metiapine: a new antipsychotic agent.	1970 Dec	4994684
Metiapine in acute schizophrenic patients.	1973 Jul	4198308
Metiapine: the evaluation of the antipsychotic properties of a new neuroleptic. A pilot study.	1973 Jul	4198309
A controlled comparison of metiapine and chlorpromazine in chronic schizophrenia.	1973 Oct	4583571
A double-blind evaluation of metiapine in hospitalized acute schizophrenics.	1975 Dec	2450

Sample Use Guides

In Vivo Use Guide

Metiapine: capsule, range 100 mg/day to 600 mg/day

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Sat Dec 16 15:52:37 GMT 2023` Edited by `admin` on `Sat Dec 16 15:52:37 GMT 2023`
Record UNII	775D6D91J8
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

METIAPINE

Official Name

English

DIBENZO(B,F)(1,4)THIAZEPINE, 2-METHYL-11-(4-METHYL-1-PIPERAZINYL)-

Systematic Name

English

metiapine [INN]

Common Name

English

METIAPINE [USAN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29710