U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

PubMed

PubMed

TitleDatePubMed
The intermediate conductance Ca2+-activated K+ channel inhibitor TRAM-34 stimulates proliferation of breast cancer cells via activation of oestrogen receptors.
2010-02-01
Differential effects of estrogen and progesterone on potassium channels expressed in Xenopus oocytes.
2008-03
Cilostazol prevents tumor necrosis factor-alpha-induced cell death by suppression of phosphatase and tensin homolog deleted from chromosome 10 phosphorylation and activation of Akt/cyclic AMP response element-binding protein phosphorylation.
2003-09
High-conductance calcium-activated potassium channels; structure, pharmacology, and function.
1996-06
Mode of action of iberiotoxin, a potent blocker of the large conductance Ca(2+)-activated K+ channel.
1992-08
Mechanism of iberiotoxin block of the large-conductance calcium-activated potassium channel from bovine aortic smooth muscle.
1992-07-28
Purification and characterization of a unique, potent, peptidyl probe for the high conductance calcium-activated potassium channel from venom of the scorpion Buthus tamulus.
1990-07-05
Substance Class Protein
Created
by admin
on Mon Mar 31 22:04:55 GMT 2025
Edited
by admin
on Mon Mar 31 22:04:55 GMT 2025
Protein Sub Type
Sequence Type COMPLETE
Record UNII
773HER9B6T
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
IBERIOTOXIN (MESOBUTHUS TAMULUS)
Preferred Name English
IBERIOTOXIN
MI  
Common Name English
IBERIOTOXIN [MI]
Common Name English
Code System Code Type Description
FDA UNII
773HER9B6T
Created by admin on Mon Mar 31 22:04:55 GMT 2025 , Edited by admin on Mon Mar 31 22:04:55 GMT 2025
PRIMARY
EPA CompTox
DTXSID801045948
Created by admin on Mon Mar 31 22:04:55 GMT 2025 , Edited by admin on Mon Mar 31 22:04:55 GMT 2025
PRIMARY
UNIPROT
P24663
Created by admin on Mon Mar 31 22:04:55 GMT 2025 , Edited by admin on Mon Mar 31 22:04:55 GMT 2025
PRIMARY
CAS
129203-60-7
Created by admin on Mon Mar 31 22:04:55 GMT 2025 , Edited by admin on Mon Mar 31 22:04:55 GMT 2025
PRIMARY
MERCK INDEX
m6183
Created by admin on Mon Mar 31 22:04:55 GMT 2025 , Edited by admin on Mon Mar 31 22:04:55 GMT 2025
PRIMARY Merck Index
From To
1_7 1_28
1_13 1_33
1_17 1_35

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO ACID SUBSTITUTION [1_1] PIDOLIC ACID SZB83O1W42
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT CHEMICAL