ADIPIC ACID

Details

Stereochemistry	ACHIRAL
Molecular Formula	C6H10O4
Molecular Weight	146.1412
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)CCCCC(O)=O

InChI

InChIKey=WNLRTRBMVRJNCN-UHFFFAOYSA-N

InChI=1S/C6H10O4/c7-5(8)3-1-2-4-6(9)10/h1-4H2,(H,7,8)(H,9,10)

HIDE SMILES / InChI

Molecular Formula	C6H10O4
Molecular Weight	146.1412
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.thechemco.com/chemical/adipic-acid/

Adipic acid has been incorporated into controlled-release formulation matrix tablets to obtain a pH-independent release for both weakly basic and weakly acidic drugs. It has also been incorporated into the polymeric coating of hydrophilic monolithic systems to modulate the intragel pH, resulting in zero-order release of hydrophilic drugs. The disintegration at intestinal pH of the enteric polymer shellac has been reported to improve when adipic acid was used as a pore-forming agent without affecting release in the acidic media. Adipic acid is used to make bisobrin an antifibrinolytic.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2596

PubMed

Title	Date	PubMed
Release profiles of theophylline from microspheres consisting of dextran derivatives and cellulose acetate butyrate: effect of polyion complex formation.	2003 Aug	12906337
Bioavailability of theophylline and thiamine disulfide incorporated into mucoadhesive microspheres consisting of dextran derivatives and cellulose acetate butyrate.	2003 Dec	14646183
A new approach in gastroretentive drug delivery system using cholestyramine.	2003 Jul-Sep	12944135
Determination of endocrine-disrupting compounds in water samples by on-line solid-phase extraction-programmed-temperature vaporisation-gas chromatography-mass spectrometry.	2003 May 23	12862370
Herbaspirillum lusitanum sp. nov., a novel nitrogen-fixing bacterium associated with root nodules of Phaseolus vulgaris.	2003 Nov	14657133
A new system in organooxotin cluster chemistry incorporating inorganic and organic spacers between two ladders each containing five tin atoms.	2004 Aug 6	15281160
Evaluation of enteric matrix microspheres prepared by emulsion-solvent evaporation using scanning electron microscopy.	2004 Feb	14718185
Synthesis and characterization of new Mg(2)Al-paratungstate layered double hydroxides.	2004 Jan 12	14704090
Crystal structure and spectroscopic study of novel two- and three-dimensional photoluminescent Eu(III)-adipate compounds.	2004 Jan 12	14704074
Human organic anion transporter 1 mediates cellular uptake of cysteine-S conjugates of inorganic mercury.	2004 Jul	15200431
Identification and quantitation of extractables from cellulose acetate butyrate (CAB) and estimation of their in vivo exposure levels.	2004 Jun 29	15193722
Differential conductance switching of planar tunnel junctions mediated by oxidation/reduction of functionally protected ferrocene.	2004 May 26	15149246
Supramolecular aggregates between carboxylate anions and an octaaza macrocyclic receptor.	2004 Oct 21	15480454
Bulk versus interfacial aqueous solvation of dicarboxylate dianions.	2004 Sep 22	15366917
catena-Poly[[aquabis(1H-benzimidazole-kappa N3)manganese(II)]-mu-adipato].	2005 Apr	15805608
X-ray studies on crystalline complexes involving amino acids and peptides. XLII. Adipic acid complexes of L- and DL-arginine and supramolecular association in arginine-dicarboxylic acid complexes.	2005 Feb	15659861
Clinic blood pressure responses to two amlodipine salt formulations, adipate and besylate, in adult Korean patients with mild to moderate hypertension: a multicenter, randomized, double-blind, parallel-group, 8-week comparison.	2005 Jun	16117979
Templated metal-organic frameworks: synthesis, structures, thermal properties and solid-state transformation of two novel calcium-adipate frameworks.	2005 Jun 21	15957051
Alkane oxidation by osmium tetroxide.	2005 Mar 9	15740101
Preparation and in vitro evaluation of propylthiouracil microspheres made of Eudragit RL 100 and cellulose acetate butyrate polymers using the emulsion-solvent evaporation method.	2005 May	16019914
Functional characterization of high-affinity Na(+)/dicarboxylate cotransporter found in Xenopus laevis kidney and heart.	2005 Nov	15944208
Increased biological hydrogen production with reduced organic loading.	2005 Oct	16129472
Production of 1,3-Propanediol by Clostridium butyricum VPI 3266 in continuous cultures with high yield and productivity.	2005 Sep	16044292
Amended final report of the safety assessment of dibutyl adipate as used in cosmetics.	2006	16835133
Crystal engineering of analogous and homologous organic compounds: hydrogen bonding patterns in trimethoprim hydrogen phthalate and trimethoprim hydrogen adipate.	2006 Apr 7	16603061
Enhancement of the Curie temperature by isomerization of diarylethene (DAE) for an organic-inorganic hybrid system: Co4(OH)7(DAE)0.5.3H2O.	2006 Dec 11	17140232
Ala-504 is a determinant of substrate binding affinity in the mouse Na(+)/dicarboxylate cotransporter.	2006 Jun	16787639
Modulatory effects of chitosan adipate on the T and B lymphocyte subsets in mice.	2006 Jun	16645341
Modelling calcium carbonate biomineralisation processes.	2006 May	16650477
Porous structures of polymer films prepared by spin coating with mixed solvents under humid condition.	2006 May 9	16649769
Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.	2006 Nov	16497524
Molecular model for host–guest interaction of tetraamino-tert-butylthiacalix[4]arene and tetraamino-tert-butylcalix[4]arene receptors with carboxylate and dicarboxylate guests: an ONIOM study.	2007	16738872
Genome analysis of Minibacterium massiliensis highlights the convergent evolution of water-living bacteria.	2007 Aug	17722982
Fluxome analysis using GC-MS.	2007 Feb 7	17286851
The relationship between instability of H2 production and compositions of bacterial communities within a dark fermentation fluidized-bed bioreactor.	2007 Jul 1	17163514
Effect of the dispersion of Eudragit S100 powder on the properties of cellulose acetate butyrate microspheres containing theophylline made by the emulsion-solvent evaporation method.	2007 May	17454437
Exploring lanthanide luminescence in metal-organic frameworks: synthesis, structure, and guest-sensitized luminescence of a mixed europium/terbium-adipate framework and a terbium-adipate framework.	2007 May 14	17439205
[(3)H]Adenine is a suitable radioligand for the labeling of G protein-coupled adenine receptors but shows high affinity to bacterial contaminations in buffer solutions.	2007 Sep	18404448
Diverse entangled metal-organic framework materials incorporating kinked organodiimine and flexible aliphatic dicarboxylate ligands: synthesis, structure, physical properties, and reversible structural reorganization.	2007 Sep 3	17691722
Preparation and characterization of hydroxyapatite/poly(ethylene adipate) hybrid composites.	2008	18544239
Organic acid concentrations in amniotic fluid found in normal and Down syndrome pregnancies.	2008	18417986
Chemical modification of zinc hydroxide nitrate and Zn-Al-layered double hydroxide with dicarboxylic acids.	2008 Apr 1	18243238
Prenatal phenol and phthalate exposures and birth outcomes.	2008 Aug	18709157
Determination of insulin in innovative formulations by means of LC coupled to fluorescence detection.	2008 Dec 15	18952391
Compatibility study of trans-1,4,5,8-tetranitro-1,4,5,8-tetraazadecalin (TNAD) with some energetic components and inert materials.	2008 Dec 30	18434010
Diclofenac sodium loaded-cellulose acetate butyrate: effect of processing variables on microparticles properties, drug release kinetics and ulcerogenic activity.	2008 Feb	18188730
Ketotifen controlled release from cellulose acetate propionate and cellulose acetate butyrate membranes.	2008 Feb	17619990
Proteomic investigation of amino acid catabolism in the indigenous gut anaerobe Fusobacterium varium.	2008 Jul	18546150
Development of a liposaccharide-based delivery system and its application to the design of group A streptococcal vaccines.	2008 Mar 13	18278857
Release profile comparison and stability of diltiazem-resin microcapsules in sustained release suspensions.	2008 Mar 20	18061381

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:45:42 GMT 2025` Edited by `admin` on `Mon Mar 31 17:45:42 GMT 2025`
Record UNII	76A0JE0FKJ
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

ADIPIC ACID

Official Name

English

E-355

Preferred Name

English

ADIPIC ACID [FCC]

Common Name

English

NSC-7622

Code

English

HEXANEDIOIC ACID

Systematic Name

English

1,4-Butanedicarboxylic acid

Systematic Name

English

ADIPIC ACID [FHFI]

Common Name

English

ADIPIC ACID [USP-RS]

Common Name

English

Adipic acid [WHO-DD]

Common Name

English

ADIPIC ACID [MART.]

Common Name

English

ADIPINIC ACID

Common Name

English

FEMA NO. 2011

Code

English

ADIPIC ACID [HSDB]

Common Name

English

INS NO.355

Code

English

INS-355

Code

English

ADIPIDIC ACID

Common Name

English

ADIPIC-ACID

Systematic Name

English

ADIPIC ACID [II]

Common Name

English

ADIPIC ACID [MI]

Common Name

English

ADIPIC ACID [EP MONOGRAPH]

Common Name

English

Classification Tree Code System Code

CFR

21 CFR 184.1009