Details
Stereochemistry | ACHIRAL |
Molecular Formula | C6H10O4 |
Molecular Weight | 146.1412 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)CCCCC(O)=O
InChI
InChIKey=WNLRTRBMVRJNCN-UHFFFAOYSA-N
InChI=1S/C6H10O4/c7-5(8)3-1-2-4-6(9)10/h1-4H2,(H,7,8)(H,9,10)
Molecular Formula | C6H10O4 |
Molecular Weight | 146.1412 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
DescriptionSources: https://www.thechemco.com/chemical/adipic-acid/
Sources: https://www.thechemco.com/chemical/adipic-acid/
Adipic acid has been incorporated into controlled-release formulation matrix tablets to obtain a pH-independent release for both weakly basic and weakly acidic drugs. It has also been incorporated into the polymeric coating of hydrophilic monolithic systems to modulate the intragel pH, resulting in zero-order release of hydrophilic drugs. The disintegration at intestinal pH of the enteric polymer shellac has been reported to improve when adipic acid was used as a pore-forming agent without affecting release in the acidic media. Adipic acid is used to make bisobrin an antifibrinolytic.
Approval Year
PubMed
Title | Date | PubMed |
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Release profiles of theophylline from microspheres consisting of dextran derivatives and cellulose acetate butyrate: effect of polyion complex formation. | 2003 Aug |
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Bioavailability of theophylline and thiamine disulfide incorporated into mucoadhesive microspheres consisting of dextran derivatives and cellulose acetate butyrate. | 2003 Dec |
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A new approach in gastroretentive drug delivery system using cholestyramine. | 2003 Jul-Sep |
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Determination of endocrine-disrupting compounds in water samples by on-line solid-phase extraction-programmed-temperature vaporisation-gas chromatography-mass spectrometry. | 2003 May 23 |
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Herbaspirillum lusitanum sp. nov., a novel nitrogen-fixing bacterium associated with root nodules of Phaseolus vulgaris. | 2003 Nov |
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A new system in organooxotin cluster chemistry incorporating inorganic and organic spacers between two ladders each containing five tin atoms. | 2004 Aug 6 |
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Evaluation of enteric matrix microspheres prepared by emulsion-solvent evaporation using scanning electron microscopy. | 2004 Feb |
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Synthesis and characterization of new Mg(2)Al-paratungstate layered double hydroxides. | 2004 Jan 12 |
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Crystal structure and spectroscopic study of novel two- and three-dimensional photoluminescent Eu(III)-adipate compounds. | 2004 Jan 12 |
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Human organic anion transporter 1 mediates cellular uptake of cysteine-S conjugates of inorganic mercury. | 2004 Jul |
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Identification and quantitation of extractables from cellulose acetate butyrate (CAB) and estimation of their in vivo exposure levels. | 2004 Jun 29 |
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Differential conductance switching of planar tunnel junctions mediated by oxidation/reduction of functionally protected ferrocene. | 2004 May 26 |
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Supramolecular aggregates between carboxylate anions and an octaaza macrocyclic receptor. | 2004 Oct 21 |
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Bulk versus interfacial aqueous solvation of dicarboxylate dianions. | 2004 Sep 22 |
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catena-Poly[[aquabis(1H-benzimidazole-kappa N3)manganese(II)]-mu-adipato]. | 2005 Apr |
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X-ray studies on crystalline complexes involving amino acids and peptides. XLII. Adipic acid complexes of L- and DL-arginine and supramolecular association in arginine-dicarboxylic acid complexes. | 2005 Feb |
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Clinic blood pressure responses to two amlodipine salt formulations, adipate and besylate, in adult Korean patients with mild to moderate hypertension: a multicenter, randomized, double-blind, parallel-group, 8-week comparison. | 2005 Jun |
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Templated metal-organic frameworks: synthesis, structures, thermal properties and solid-state transformation of two novel calcium-adipate frameworks. | 2005 Jun 21 |
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Alkane oxidation by osmium tetroxide. | 2005 Mar 9 |
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Preparation and in vitro evaluation of propylthiouracil microspheres made of Eudragit RL 100 and cellulose acetate butyrate polymers using the emulsion-solvent evaporation method. | 2005 May |
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Functional characterization of high-affinity Na(+)/dicarboxylate cotransporter found in Xenopus laevis kidney and heart. | 2005 Nov |
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Increased biological hydrogen production with reduced organic loading. | 2005 Oct |
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Production of 1,3-Propanediol by Clostridium butyricum VPI 3266 in continuous cultures with high yield and productivity. | 2005 Sep |
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Amended final report of the safety assessment of dibutyl adipate as used in cosmetics. | 2006 |
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Crystal engineering of analogous and homologous organic compounds: hydrogen bonding patterns in trimethoprim hydrogen phthalate and trimethoprim hydrogen adipate. | 2006 Apr 7 |
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Enhancement of the Curie temperature by isomerization of diarylethene (DAE) for an organic-inorganic hybrid system: Co4(OH)7(DAE)0.5.3H2O. | 2006 Dec 11 |
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Ala-504 is a determinant of substrate binding affinity in the mouse Na(+)/dicarboxylate cotransporter. | 2006 Jun |
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Modulatory effects of chitosan adipate on the T and B lymphocyte subsets in mice. | 2006 Jun |
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Modelling calcium carbonate biomineralisation processes. | 2006 May |
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Porous structures of polymer films prepared by spin coating with mixed solvents under humid condition. | 2006 May 9 |
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Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods. | 2006 Nov |
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Molecular model for host–guest interaction of tetraamino-tert-butylthiacalix[4]arene and tetraamino-tert-butylcalix[4]arene receptors with carboxylate and dicarboxylate guests: an ONIOM study. | 2007 |
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Genome analysis of Minibacterium massiliensis highlights the convergent evolution of water-living bacteria. | 2007 Aug |
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Fluxome analysis using GC-MS. | 2007 Feb 7 |
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The relationship between instability of H2 production and compositions of bacterial communities within a dark fermentation fluidized-bed bioreactor. | 2007 Jul 1 |
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Effect of the dispersion of Eudragit S100 powder on the properties of cellulose acetate butyrate microspheres containing theophylline made by the emulsion-solvent evaporation method. | 2007 May |
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Exploring lanthanide luminescence in metal-organic frameworks: synthesis, structure, and guest-sensitized luminescence of a mixed europium/terbium-adipate framework and a terbium-adipate framework. | 2007 May 14 |
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[(3)H]Adenine is a suitable radioligand for the labeling of G protein-coupled adenine receptors but shows high affinity to bacterial contaminations in buffer solutions. | 2007 Sep |
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Diverse entangled metal-organic framework materials incorporating kinked organodiimine and flexible aliphatic dicarboxylate ligands: synthesis, structure, physical properties, and reversible structural reorganization. | 2007 Sep 3 |
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Preparation and characterization of hydroxyapatite/poly(ethylene adipate) hybrid composites. | 2008 |
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Organic acid concentrations in amniotic fluid found in normal and Down syndrome pregnancies. | 2008 |
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Chemical modification of zinc hydroxide nitrate and Zn-Al-layered double hydroxide with dicarboxylic acids. | 2008 Apr 1 |
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Prenatal phenol and phthalate exposures and birth outcomes. | 2008 Aug |
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Determination of insulin in innovative formulations by means of LC coupled to fluorescence detection. | 2008 Dec 15 |
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Compatibility study of trans-1,4,5,8-tetranitro-1,4,5,8-tetraazadecalin (TNAD) with some energetic components and inert materials. | 2008 Dec 30 |
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Diclofenac sodium loaded-cellulose acetate butyrate: effect of processing variables on microparticles properties, drug release kinetics and ulcerogenic activity. | 2008 Feb |
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Ketotifen controlled release from cellulose acetate propionate and cellulose acetate butyrate membranes. | 2008 Feb |
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Proteomic investigation of amino acid catabolism in the indigenous gut anaerobe Fusobacterium varium. | 2008 Jul |
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Development of a liposaccharide-based delivery system and its application to the design of group A streptococcal vaccines. | 2008 Mar 13 |
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Release profile comparison and stability of diltiazem-resin microcapsules in sustained release suspensions. | 2008 Mar 20 |
Patents
Substance Class |
Chemical
Created
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admin
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Record UNII |
76A0JE0FKJ
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Validated (UNII)
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CFR |
21 CFR 184.1009
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JECFA EVALUATION |
ADIPIC ACID
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JECFA EVALUATION |
INS-355
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CODEX ALIMENTARIUS (GSFA) |
INS-355
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ADIPIC ACID
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30832
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188
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C76697
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C45678
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7622
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m1420
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76A0JE0FKJ
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