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Details

Stereochemistry ACHIRAL
Molecular Formula C20H2Br4Cl4O5.2Na
Molecular Weight 829.634
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of D&C RED NO. 28

SMILES

[Na+].[Na+].[O-]C(=O)C1=C(C(Cl)=C(Cl)C(Cl)=C1Cl)C2=C3C=C(Br)C(=O)C(Br)=C3OC4=C2C=C(Br)C([O-])=C4Br

InChI

InChIKey=GVKCHTBDSMQENH-UHFFFAOYSA-L
InChI=1S/C20H4Br4Cl4O5.2Na/c21-5-1-3-7(8-9(20(31)32)13(26)15(28)14(27)12(8)25)4-2-6(22)17(30)11(24)19(4)33-18(3)10(23)16(5)29;;/h1-2,29H,(H,31,32);;/q;2*+1/p-2

HIDE SMILES / InChI
Molecular Formula Na
Molecular Weight 22.98976928
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula C20H2Br4Cl4O5
Molecular Weight 783.655
Charge -2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

D and C Red No. 28 (Red 28) FDA-approved color additive used in drugs and cosmetics, including lip and eye care products, face makeups, personal care products. It is also used in biological stains, inks, and lacquers for coating and dyeing paper. D and C Red No. 28 was also investigated for use as a fruit fly pesticide. A safe level of exposure for Red 28 is considered 1.25 mg/kg /day.

Approval Year

1961
146
PubMed

PubMed

TitleDatePubMed
Absorption and elimination of D and C Red No. 28 in male F-344 rats.
2004-04
Patents

Patents

JP2001221798A
1
JP2003246917A
1
JP2003327813A
1
JP2007509197A
1
JP2009256541A
1
JP2009256543A
1
JP2009256544A
1
JP2009256546A
1
JP2009256547A
1
JP2011195681A
1
JP2011195682A
1
JP2012500865A
16
JPH06128128A
1
JPS5576821A
1
JPS56157469A
1
JPS58141261A
1
JPS58141262A
1
JPS58141263A
1
JPS58141264A
1
JPS58204068A
1
JPS61179275A
5
Substance Class Chemical
Created
by admin
on Mon Mar 31 18:24:44 GMT 2025
Edited
by admin
on Mon Mar 31 18:24:44 GMT 2025
Record UNII
767IP0Y5NH
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
RED 28
INCI  
INCI  
Preferred Name English
D&C RED NO. 28
II  
Common Name English
CI 45410
INCI  
INCI  
Preferred Name English
ACID RED 92
INCI  
INCI  
Preferred Name English
AKA104(1)
INCI  
INCI  
Preferred Name English
PHLOXINE B [MI]
Common Name English
JAPAN RED 104
Common Name English
D & C RED #28 [VANDF]
Common Name English
D&C RED NO. 28 [II]
Common Name English
FLUORESCEIN, 2',4',5',7'-TETRABROMO-4,5,6,7-TETRACHLORO-, DISODIUM SALT
Systematic Name English
C.I. ACID RED 92
Common Name English
NSC-10462
Code English
PHLOXIN B
Common Name English
RED NO. 104
Common Name English
D & C RED NO. 28
Common Name English
CYANOSIN
Common Name English
FD&C RED NO. 28 (DELISTED) [II]
Common Name English
PHLOXINE B
MI  
Common Name English
SPIRO(ISOBENZOFURAN-1(3H),9'-(9H)XANTHEN)-3-ONE, 2',4',5',7'-TETRABROMO-4,5,6,7-TETRACHLORO-3',6'-DIHYDROXY-, DISODIUM SALT
Systematic Name English
D&C RED NO. 27 DISODIUM SALT
Common Name English
2,4,5,7-TETRABROMO-4,5,6,7-TETRACHLOROFLUORESCEIN DISODIUM SALT
Common Name English
EOSIN BLUE
Common Name English
C.I. 45410
Common Name English
DC RED NO. 28
Common Name English
SPIRO(ISOBENZOFURAN-1(3H),9'-(9H)XANTHEN)-3-ONE, 2',4',5',7'-TETRABROMO-4,5,6,7-TETRACHLORO-3',6'-DIHYDROXY-, SODIUM SALT (1:2)
Systematic Name English
FD&C RED NO. 28 (DELISTED)
II  
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C461
Created by admin on Mon Mar 31 18:24:44 GMT 2025 , Edited by admin on Mon Mar 31 18:24:44 GMT 2025
CFR 21 CFR 74.2328
Created by admin on Mon Mar 31 18:24:44 GMT 2025 , Edited by admin on Mon Mar 31 18:24:44 GMT 2025
CFR 21 CFR 74.1328
Created by admin on Mon Mar 31 18:24:44 GMT 2025 , Edited by admin on Mon Mar 31 18:24:44 GMT 2025
Code System Code Type Description
DRUG BANK
DB13911
Created by admin on Mon Mar 31 18:24:44 GMT 2025 , Edited by admin on Mon Mar 31 18:24:44 GMT 2025
PRIMARY
NCI_THESAURUS
C71660
Created by admin on Mon Mar 31 18:24:44 GMT 2025 , Edited by admin on Mon Mar 31 18:24:44 GMT 2025
PRIMARY
DAILYMED
767IP0Y5NH
Created by admin on Mon Mar 31 18:24:44 GMT 2025 , Edited by admin on Mon Mar 31 18:24:44 GMT 2025
PRIMARY
NSC
10462
Created by admin on Mon Mar 31 18:24:44 GMT 2025 , Edited by admin on Mon Mar 31 18:24:44 GMT 2025
PRIMARY
CHEBI
87192
Created by admin on Mon Mar 31 18:24:44 GMT 2025 , Edited by admin on Mon Mar 31 18:24:44 GMT 2025
PRIMARY
WIKIPEDIA
D & C Red no. 28
Created by admin on Mon Mar 31 18:24:44 GMT 2025 , Edited by admin on Mon Mar 31 18:24:44 GMT 2025
PRIMARY
RXCUI
1310707
Created by admin on Mon Mar 31 18:24:44 GMT 2025 , Edited by admin on Mon Mar 31 18:24:44 GMT 2025
PRIMARY RxNorm
ECHA (EC/EINECS)
242-355-6
Created by admin on Mon Mar 31 18:24:44 GMT 2025 , Edited by admin on Mon Mar 31 18:24:44 GMT 2025
PRIMARY
EPA CompTox
DTXSID1031090
Created by admin on Mon Mar 31 18:24:44 GMT 2025 , Edited by admin on Mon Mar 31 18:24:44 GMT 2025
PRIMARY
CAS
4618-23-9
Created by admin on Mon Mar 31 18:24:44 GMT 2025 , Edited by admin on Mon Mar 31 18:24:44 GMT 2025
ALTERNATIVE
FDA UNII
767IP0Y5NH
Created by admin on Mon Mar 31 18:24:44 GMT 2025 , Edited by admin on Mon Mar 31 18:24:44 GMT 2025
PRIMARY
PUBCHEM
2724057
Created by admin on Mon Mar 31 18:24:44 GMT 2025 , Edited by admin on Mon Mar 31 18:24:44 GMT 2025
PRIMARY
SMS_ID
100000172074
Created by admin on Mon Mar 31 18:24:44 GMT 2025 , Edited by admin on Mon Mar 31 18:24:44 GMT 2025
PRIMARY
MERCK INDEX
m8710
Created by admin on Mon Mar 31 18:24:44 GMT 2025 , Edited by admin on Mon Mar 31 18:24:44 GMT 2025
PRIMARY Merck Index
CAS
18472-87-2
Created by admin on Mon Mar 31 18:24:44 GMT 2025 , Edited by admin on Mon Mar 31 18:24:44 GMT 2025
PRIMARY
NIH
NCATS
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