Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C8H19O2PS2 |
| Molecular Weight | 242.339 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCSP(=O)(OCC)SCCC
InChI
InChIKey=VJYFKVYYMZPMAB-UHFFFAOYSA-N
InChI=1S/C8H19O2PS2/c1-4-7-12-11(9,10-6-3)13-8-5-2/h4-8H2,1-3H3
| Molecular Formula | C8H19O2PS2 |
| Molecular Weight | 242.339 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Ethoprophos is a broad-spectrum nematicide and insecticide used pre-planting to control nematodes and soil dwelling insects. Research and testing has shown ethoprophos to offer effective control for soil nematodes and insects when used according to label guidelines. Ethoprophos is a cholinesterase inhibitor.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Peripheral nervous system function and organophosphate pesticide use among licensed pesticide applicators in the Agricultural Health Study. | 2012-04 |
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| Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets. | 2011-03-28 |
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| Comparative study of human and mouse pregnane X receptor agonistic activity in 200 pesticides using in vitro reporter gene assays. | 2011-02-27 |
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| Miticide residues in Virginia honeys. | 2009-12 |
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| Evaluation of multi-walled carbon nanotubes as solid-phase extraction adsorbents of pesticides from agricultural, ornamental and forestal soils. | 2009-08-11 |
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| Longitudinal trends in organophosphate incidents reported to the National Pesticide Information Center, 1995-2007. | 2009-04-20 |
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| Multivariate analysis of toxicological and environmental properties of soil nematicides. | 2009-01 |
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| Multi-walled carbon nanotubes as efficient solid-phase extraction materials of organophosphorus pesticides from apple, grape, orange and pineapple fruit juices. | 2008-11-21 |
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| Companion animals as sentinels for community exposure to industrial chemicals: the Fairburn, GA, propyl mercaptan case study. | 2008-11-15 |
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| Parallel assessment of male reproductive function in workers and wild rats exposed to pesticides in banana plantations in Guadeloupe. | 2008-07-30 |
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| Parameters affecting microwave-assisted extraction of organophosphorus pesticides from agricultural soil. | 2007-10-26 |
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| Control of Meloidogyne chitwoodi in Potato with Shank-injected Metam Sodium and other Nematicides. | 2007-06 |
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| [Determination of organic phosphorus pesticide residues in scallion by gas chromatography coupled with microwave clean-up]. | 2007-05 |
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| Determination of ethoprop, diazinon, disulfoton and fenthion using dynamic hollow fiber-protected liquid-phase microextraction coupled with gas chromatography-mass spectrometry. | 2006-05-15 |
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| Determination of pesticides by solid phase extraction followed by gas chromatography with nitrogen-phosphorous detection in natural water and comparison with solvent drop microextraction. | 2006-02 |
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| Non-specific biodegradation of the organophosphorus pesticides, cadusafos and ethoprophos, by two bacterial isolates. | 2005-08-01 |
|
| Determination of nine organophosphorus pesticides in cereals and kidney beans by capillary gas chromatography with flame photometric detection. | 2005-08 |
|
| Prediction of pesticide volatilization with PELMO 3.31. | 2005-07 |
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| Measuring and predicting environmental concentrations of pesticides in air after application to paddy water systems. | 2005-05-01 |
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| Application of hollow fiber liquid phase microextraction for the determination of insecticides in water. | 2005-04-22 |
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| Biological monitoring use in refining the exposure assessment of agricultural operators. | 2005 |
|
| Pesticide patch test series for the assessment of allergic contact dermatitis among banana plantation workers in panama. | 2004-09 |
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| The enhanced biodegradation of fenamiphos in soils from previously treated sites and the effect of soil fumigants. | 2004-09 |
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| Enhanced microbial degradation of cadusafos in soils from potato monoculture: demonstration and characterization. | 2004-08 |
|
| Evaluation of large volume-difficult matrix introduction-gas chromatography-time of flight-mass spectrometry (LV-DMI-GC-TOF-MS) for the determination of pesticides in fruit-based baby foods. | 2004-07 |
|
| Study of the mechanism of Flavobacterium sp. for hydrolyzing organophosphate pesticides. | 2003-12 |
|
| Predicting and measuring environmental concentration of pesticides in air after soil application. | 2003-10-11 |
|
| Degradation of ethoprophos in three physicochemically different soils treated with composted manure and chemical fertilizer. | 2003-03 |
|
| Parameterisation, evaluation and comparison of pesticide leaching models to data from a Bologna field site, Italy. | 2003-01 |
|
| Identification of alternatives for the management of foliar nematodes in floriculture. | 2002-05 |
|
| Analysis of 1,3-Dichloropropene for Control of Meloidogyne spp. in a Tobacco Pest Management System. | 2001-12 |
|
| Crop Rotation and Nematicides for Management of Mixed Populations of Meloidogyne spp. on Tobacco. | 2001-12 |
|
| Protection against drug- and chemical-induced multiorgan toxicity by a novel IH636 grape seed proanthocyanidin extract. | 2001 |
Patents
Sample Use Guides
In an in vivo cytogenetic study, groups of male Sprague-Dawley rats were treated orally with technical ethoprophos (95.7 percent) at 0, 2, 9 or 20 mg/kg b.w./day for five consecutive days. The animals were given colchicine i.p. at 4 mg/kg b.w. four hours after the last dose and then sacrificed two hours later for metaphase analysis of bone marrow cells. There was no significant difference between control and treated groups in the incidence of bone marrow cells with chromosomal aberrations.
Route of Administration:
Oral
In Vitro Use Guide
Curator's Comment: Ethoprophos concentration of 400 ug/L caused a ChE inhibition by 79%. https://www.ncbi.nlm.nih.gov/pubmed/22458230
Ethoprophos, at the non-toxic concentrations ranging from 2.5 to 25 nl/ml, did not induce a detectable level of unscheduled DNA synthesis in primary rat hepatocytes in vitro.
| Substance Class |
Chemical
Created
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Mon Mar 31 18:44:31 GMT 2025
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| Record UNII |
765Y5683OQ
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| Record Status |
Validated (UNII)
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EPA PESTICIDE CODE |
41101
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236-152-1
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ethoprophos
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ETHOPROP
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