U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
Benzylpenicilloyl Polylysine is a skin-testing reagent which used to detect immunoglobulin E antibodies in people with a history of penicillin allergy. The quantitation of in vitro IgE antibodies to the benzylpenicilloyl determinant is a useful tool for evaluating allergic subjects. A penicillin skin test predicts only the presence of IgE antibodies for the major or minor penicillin determinants at the time of application and does not predict the future development of IgE-mediated reactions during subsequent courses of penicillin. Benzylpenicilloyl polylysine reacts specifically with penicilloyl skin sensitizing antibodies (reagins) to produce immediate wheal and flare reactions which may reflect increased risk of allergic reactions to subsequent penicillin therapy. The use of benzylpenicilloyl polylysine can detect between 75-90% of all positive reactions to penicillin. Benzylpenicilloyl polylysine was FDA approved in 2009 for the assessment of sensitization to penicillin (benzylpenicillin or penicillin G) in those patients suspected of having a clinical hypersensitivity to penicillin.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
PRE-PEN

Approved Use

PREPEN is indicated for the assessment of sensitization to penicillin (benzylpenicillin or penicillin G) in patients suspected to have clinical penicillin hypersensitivity. A negative skin test to PREPEN is associated with an incidence of immediate allergic reactions of less than 5% after the administration of therapeutic penicillin, whereas the incidence may be more than 50% in a history-positive patient with a positive skin test to PREPEN. These allergic reactions are predominantly dermatologic. Whether a negative skin test to PREPEN predicts a lower risk of anaphylaxis is not established. Similarly, when deciding the risk of proposed penicillin treatment, there are not enough data at present to permit relative weighing in individual cases of a history of clinical penicillin hypersensitivity as compared to positive skin tests to PREPEN and/or minor penicillin determinants.

Launch Date

1.43855993E11
Substance Class Polymer
Created
by admin
on Sat Jun 26 18:58:05 UTC 2021
Edited
by admin
on Sat Jun 26 18:58:05 UTC 2021
Record UNII
76479814OY
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
BENZYLPENICILLOYL POLYLYSINE
ORANGE BOOK   USP   VANDF  
Common Name English
BENZYLPENICILLOYL OCTA-L-LYSINE
Common Name English
BENZYLPENICILLOYL-POLYLYSINE
Common Name English
BENZYLPENICILLOYL POLYLYSINE [ORANGE BOOK]
Common Name English
BENZYLPENICILLOYL POLYLYSINE [USP]
Common Name English
BENZYL PENICILLOYL-POLYLYSINE
Common Name English
BENZYLPENICILLOYL POLYLYSINE [VANDF]
Common Name English
L-LYSINE, HOMOPOLYMER, (2S-(2.ALPHA.,5.ALPHA.,6.BETA.))-3,3-DIMETHYL-7-OXO-6-((2-PHENYLACETYL)AMINO)-4-THIA-1-AZABICYCLO(3.2.0)HEPTANE-2-CARBOXYLATE (1:1)
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C1937
Created by admin on Sat Jun 26 18:58:05 UTC 2021 , Edited by admin on Sat Jun 26 18:58:05 UTC 2021
Code System Code Type Description
ChEMBL
CHEMBL1201779
Created by admin on Sat Jun 26 18:58:05 UTC 2021 , Edited by admin on Sat Jun 26 18:58:05 UTC 2021
PRIMARY
EPA CompTox
31855-75-1
Created by admin on Sat Jun 26 18:58:05 UTC 2021 , Edited by admin on Sat Jun 26 18:58:05 UTC 2021
PRIMARY
PUBCHEM
23724855
Created by admin on Sat Jun 26 18:58:05 UTC 2021 , Edited by admin on Sat Jun 26 18:58:05 UTC 2021
PRIMARY
CAS
31855-75-1
Created by admin on Sat Jun 26 18:58:05 UTC 2021 , Edited by admin on Sat Jun 26 18:58:05 UTC 2021
PRIMARY
NCI_THESAURUS
C87447
Created by admin on Sat Jun 26 18:58:05 UTC 2021 , Edited by admin on Sat Jun 26 18:58:05 UTC 2021
PRIMARY
DRUG CENTRAL
4717
Created by admin on Sat Jun 26 18:58:05 UTC 2021 , Edited by admin on Sat Jun 26 18:58:05 UTC 2021
PRIMARY
RXCUI
19079
Created by admin on Sat Jun 26 18:58:05 UTC 2021 , Edited by admin on Sat Jun 26 18:58:05 UTC 2021
PRIMARY RxNorm
FDA UNII
76479814OY
Created by admin on Sat Jun 26 18:58:05 UTC 2021 , Edited by admin on Sat Jun 26 18:58:05 UTC 2021
PRIMARY
DRUG BANK
DB00895
Created by admin on Sat Jun 26 18:58:05 UTC 2021 , Edited by admin on Sat Jun 26 18:58:05 UTC 2021
PRIMARY
Display Structure of BENZYLPENICILLOYL POLYLYSINE
Related Record Type Details
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:WEIGHT AVERAGE CHEMICAL