METKEPHAMID ACETATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C29H40N6O6S.C2H4O2
Molecular Weight	660.781
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(O)=O.CSCC[C@H](N(C)C(=O)[C@H](CC1=CC=CC=C1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)CC2=CC=C(O)C=C2)C(N)=O

InChI

InChIKey=MCEMSMUXOSFTJG-KBUZRCILSA-N

InChI=1S/C29H40N6O6S.C2H4O2/c1-18(33-28(40)22(30)15-20-9-11-21(36)12-10-20)27(39)32-17-25(37)34-23(16-19-7-5-4-6-8-19)29(41)35(2)24(26(31)38)13-14-42-3;1-2(3)4/h4-12,18,22-24,36H,13-17,30H2,1-3H3,(H2,31,38)(H,32,39)(H,33,40)(H,34,37);1H3,(H,3,4)/t18-,22+,23+,24+;/m1./s1

HIDE SMILES / InChI

Molecular Formula	C29H40N6O6S
Molecular Weight	600.73
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	C2H4O2
Molecular Weight	60.052
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6872419 | https://www.ncbi.nlm.nih.gov/pubmed/6256856

Approval Year

PubMed

Title	Date	PubMed
Metkephamid, a systemically active analog of methionine enkephalin with potent opioid alpha-receptor activity.	1981 Feb 6	6256856
Metkephamid (Tyr-D-ala-Gly-Phe-N(Me)Met-NH2), a potent opioid peptide: receptor binding and analgesic properties.	1982 Sep-Oct	6294639

Sample Use Guides

In Vivo Use Guide

The efficacy, safety, and time course of analgesia with 70 or 140 mg metkephamid were compared with those of 100 mg meperidine and placebo in 59 hospitalized women with severe postpartum episiotomy pain.

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 18:56:57 GMT 2023` Edited by `admin` on `Fri Dec 15 18:56:57 GMT 2023`
Record UNII	75Y5J06JPC
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

METKEPHAMID ACETATE

Official Name

English

L-TYROSYL-D-ALANYLGLYCYL-L-PHENYLALANYL-N(SUP 2)-METHYL-L-METHIONINAMIDE MONOACETATE (SALT)

Common Name

English

LY-127623

Code

English

METKEPHAMID ACETATE [USAN]

Common Name

English

LY 127623

Code

English

L-METHIONINAMIDE, L-TYROSYL-D-ALANYLGLYCYL-L-PHENYLALANYL-N(SUP 2)-METHYL-, MONOACETATE (SALT)

Common Name

English

METKEFAMIDE ACETATE

Common Name

English

Code System Code Type Description

PUBCHEM

5464183