CASTICIN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H18O8
Molecular Weight	374.3414
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC=C(C=C1O)C2=C(OC)C(=O)C3=C(O2)C=C(OC)C(OC)=C3O

InChI

InChIKey=PJQLSMYMOKWUJG-UHFFFAOYSA-N

InChI=1S/C19H18O8/c1-23-11-6-5-9(7-10(11)20)17-19(26-4)16(22)14-12(27-17)8-13(24-2)18(25-3)15(14)21/h5-8,20-21H,1-4H3

HIDE SMILES / InChI

Molecular Formula	C19H18O8
Molecular Weight	374.3414
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Traditional herbal medicine in far-west Nepal: a pharmacological appraisal.	2010-12-13	21144003
Casticin, a flavonoid isolated from Vitex rotundifolia, inhibits prolactin release in vivo and in vitro.	2010-12	21042288
[Preparative isolation and purification of the active components from Viticis Fructus by high-speed counter-current chromatography].	2010-11	21381420
Semisynthesis of natural flavones inhibiting tubulin polymerization, from hesperidin.	2010-04-23	20356063
Effects of the flavonoid casticin from Brazilian Croton betulaster in cerebral cortical progenitors in vitro: direct and indirect action through astrocytes.	2010-02-15	19746423
Isolation and immunomodulatory properties of a flavonoid, casticin from Vitex agnus-castus.	2009-11	19441009
Antiinflammatory and lipoxygenase inhibitory compounds from Vitex agnus-castus.	2009-09	19173281
Casticin induces leukemic cell death through apoptosis and mitotic catastrophe.	2009-08	19139893
Antiproliferative effect of flavonoids and sesquiterpenoids from Achillea millefolium s.l. on cultured human tumour cell lines.	2009-05	19107850
Antiproliferative and cytostatic effects of the natural product eupatorin on MDA-MB-468 human breast cancer cells due to CYP1-mediated metabolism.	2008	18454852
Anti-nociceptive and anti-hyperprolactinemia activities of Fructus Viticis and its effective fractions and chemical constituents.	2007-10	17350238
Evaluation of the estrogenic activity of the constituents in the fruits of Vitex rotundifolia L. for the potential treatment of premenstrual syndrome.	2007-09	17883902
In vivo effect of casticin on acute inflammation.	2007-09	17854563
Isolation of high-purity casticin from Artemisia annua L. by high-speed counter-current chromatography.	2007-06-01	17374377
Diterpenoids and flavonoids from the fruits of Vitex agnus-castus and antioxidant activity of the fruit extracts and their constituents.	2007-04	17262892
The flavonoid Casticin has multiple mechanisms of tumor cytotoxicity action.	2006-10-28	16387422
Are extraction methods in quantitative assays of pharmacopoeia monographs exhaustive? A comparison with pressurized liquid extraction.	2006-10	16924586
The Systemic Theory of Living Systems. Part IV: Systemic Medicine--The Praxis.	2005-12	16322799
[Vitexicarpin, a flavonoid from Vitex trifolia L., induces apoptosis in K562 cells via mitochondria-controlled apoptotic pathway].	2005-01	15881322
G2-M arrest and antimitotic activity mediated by casticin, a flavonoid isolated from Viticis Fructus (Vitex rotundifolia Linne fil.).	2004-05-10	15105046
Characteristics, clinical effect profile and tolerability of a nasal spray preparation of Artemisia abrotanum L. for allergic rhinitis.	2004-01	14971719
Cytotoxic flavone analogues of vitexicarpin, a constituent of the leaves of Vitex negundo.	2003-06	12828478
Tracheospasmolytic activity of viteosin-A and vitexicarpin isolated from vitex trifolia.	2002-11	12451502
New diterpenes and norditerpenes from the fruits of Vitex rotundifolia.	2002-04	11975496
Enzymatic synthesis of polymethylated flavonols in Chrysosplenium americanum. II. Substrate interaction and product inhibition studies of flavonol 3-, 6-, and 4'-O-methyltransferases.	1985-05-01	3994394

Substance Class	Chemical Created by `admin` on `Mon Mar 31 19:22:14 GMT 2025` Edited by `admin` on `Mon Mar 31 19:22:14 GMT 2025`
Record UNII	753GT729OU
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

CASTICIN [USP-RS]

Preferred Name

English

CASTICIN

Common Name

English

4H-1-BENZOPYRAN-4-ONE, 5-HYDROXY-2-(3-HYDROXY-4-METHOXYPHENYL)-3,6,7-TRIMETHOXY-

Systematic Name

English

5-HYDROXY-2-(3-HYDROXY-4-METHOXY-PHENYL)-3,6,7-TRIMETHOXY-CHROMEN-4-ONE

Systematic Name

English

Code System Code Type Description

CAS

479-91-4