CASTICIN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H18O8
Molecular Weight	374.3414
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC=C(C=C1O)C2=C(OC)C(=O)C3=C(O)C(OC)=C(OC)C=C3O2

InChI

InChIKey=PJQLSMYMOKWUJG-UHFFFAOYSA-N

InChI=1S/C19H18O8/c1-23-11-6-5-9(7-10(11)20)17-19(26-4)16(22)14-12(27-17)8-13(24-2)18(25-3)15(14)21/h5-8,20-21H,1-4H3

HIDE SMILES / InChI

Molecular Formula	C19H18O8
Molecular Weight	374.3414
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
New diterpenes and norditerpenes from the fruits of Vitex rotundifolia.	2002 Apr	11975496
Tracheospasmolytic activity of viteosin-A and vitexicarpin isolated from vitex trifolia.	2002 Nov	12451502
Characteristics, clinical effect profile and tolerability of a nasal spray preparation of Artemisia abrotanum L. for allergic rhinitis.	2004 Jan	14971719
The Systemic Theory of Living Systems. Part IV: Systemic Medicine--The Praxis.	2005 Dec	16322799
Are extraction methods in quantitative assays of pharmacopoeia monographs exhaustive? A comparison with pressurized liquid extraction.	2006 Oct	16924586
The flavonoid Casticin has multiple mechanisms of tumor cytotoxicity action.	2006 Oct 28	16387422
Isolation of high-purity casticin from Artemisia annua L. by high-speed counter-current chromatography.	2007 Jun 1	17374377
Anti-nociceptive and anti-hyperprolactinemia activities of Fructus Viticis and its effective fractions and chemical constituents.	2007 Oct	17350238
Evaluation of the estrogenic activity of the constituents in the fruits of Vitex rotundifolia L. for the potential treatment of premenstrual syndrome.	2007 Sep	17883902
Antiproliferative and cytostatic effects of the natural product eupatorin on MDA-MB-468 human breast cancer cells due to CYP1-mediated metabolism.	2008	18454852
Antiproliferative effect of flavonoids and sesquiterpenoids from Achillea millefolium s.l. on cultured human tumour cell lines.	2009 May	19107850
Antiinflammatory and lipoxygenase inhibitory compounds from Vitex agnus-castus.	2009 Sep	19173281
Casticin, a flavonoid isolated from Vitex rotundifolia, inhibits prolactin release in vivo and in vitro.	2010 Dec	21042288
Traditional herbal medicine in far-west Nepal: a pharmacological appraisal.	2010 Dec 13	21144003
[Preparative isolation and purification of the active components from Viticis Fructus by high-speed counter-current chromatography].	2010 Nov	21381420

Substance Class	Chemical Created by `admin` on `Fri Dec 15 18:50:33 UTC 2023` Edited by `admin` on `Fri Dec 15 18:50:33 UTC 2023`
Record UNII	753GT729OU
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CASTICIN

Common Name

English

4H-1-BENZOPYRAN-4-ONE, 5-HYDROXY-2-(3-HYDROXY-4-METHOXYPHENYL)-3,6,7-TRIMETHOXY-

Systematic Name

English

CASTICIN [USP-RS]

Common Name

English

5-HYDROXY-2-(3-HYDROXY-4-METHOXY-PHENYL)-3,6,7-TRIMETHOXY-CHROMEN-4-ONE

Systematic Name

English

Code System Code Type Description

CAS

479-91-4