TANDAMINE HYDROCHLORIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C18H26N2S.ClH
Molecular Weight	338.938
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CCN1C2=C(C=CC=C2)C3=C1C(C)(CCN(C)C)SCC3

InChI

InChIKey=FJJSKKBQSGDHQK-UHFFFAOYSA-N

InChI=1S/C18H26N2S.ClH/c1-5-20-16-9-7-6-8-14(16)15-10-13-21-18(2,17(15)20)11-12-19(3)4;/h6-9H,5,10-13H2,1-4H3;1H

HIDE SMILES / InChI

Molecular Formula	C18H26N2S
Molecular Weight	302.477
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/403562 | https://www.ncbi.nlm.nih.gov/pubmed/503251 | https://www.ncbi.nlm.nih.gov/pubmed/334686

Tandamine was developed as a selective serotonin reuptake inhibitor for the treatment of depression. Tandamine participated in clinical trials in hospitalized depressed patients, where it showed that the well-tolerated drug could be of some benefit for retarded depressions. In addition, was found in human volunteers, that tandamine possessed significant anticholinergic activity, to reduce appetite and to produce sedation. However, this drug has never been marketed.

Approval Year

PubMed

Title	Date	PubMed

Patents

Sample Use Guides

In Vivo Use Guide

was administered in doses from 75 to 200 mg to a group of 20 hospitalized depressed patients.

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:13:20 GMT 2023` Edited by `admin` on `Fri Dec 15 15:13:20 GMT 2023`
Record UNII	7516K9UGUG
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TANDAMINE HYDROCHLORIDE

Official Name

English

TANDAMINE HYDROCHLORIDE [USAN]

Common Name

English

AY23946

Code

English

THIOPYRANO(3,4-B)INDOLE-1-ETHANAMINE, 9-ETHYL-1,3,4,9-TETRAHYDRO-N,N,1-TRIMETHYL-, MONOHYDROCHLORIDE

Common Name

English

AY-23946

Code

English

1-[2-(Dimethylamino)ethyl]-9-ethyl-1,3,4,9-tetrahydro-1-methylthiopyrano[3,4-b]-indole monohydrochloride

Systematic Name

English

NSC-305532

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C265