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Details

Stereochemistry RACEMIC
Molecular Formula C18H26N2S.ClH
Molecular Weight 338.938
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TANDAMINE HYDROCHLORIDE

SMILES

Cl.CCN1C2=C(C=CC=C2)C3=C1C(C)(CCN(C)C)SCC3

InChI

InChIKey=FJJSKKBQSGDHQK-UHFFFAOYSA-N
InChI=1S/C18H26N2S.ClH/c1-5-20-16-9-7-6-8-14(16)15-10-13-21-18(2,17(15)20)11-12-19(3)4;/h6-9H,5,10-13H2,1-4H3;1H

HIDE SMILES / InChI

Molecular Formula C18H26N2S
Molecular Weight 302.477
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Tandamine was developed as a selective serotonin reuptake inhibitor for the treatment of depression. Tandamine participated in clinical trials in hospitalized depressed patients, where it showed that the well-tolerated drug could be of some benefit for retarded depressions. In addition, was found in human volunteers, that tandamine possessed significant anticholinergic activity, to reduce appetite and to produce sedation. However, this drug has never been marketed.

Approval Year

PubMed

Sample Use Guides

In Vivo Use Guide
was administered in doses from 75 to 200 mg to a group of 20 hospitalized depressed patients.
Route of Administration: Oral
Substance Class Chemical
Record UNII
7516K9UGUG
Record Status Validated (UNII)
Record Version