POMIFERIN

Possibly Marketed Outside US

First approved in 2022

Details

Stereochemistry	ACHIRAL
Molecular Formula	C25H24O6
Molecular Weight	420.4545
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)=CCC1=C(O)C2=C(OC=C(C2=O)C3=CC=C(O)C(O)=C3)C4=C1OC(C)(C)C=C4

InChI

InChIKey=GHCZYXUOYFOXIP-UHFFFAOYSA-N

InChI=1S/C25H24O6/c1-13(2)5-7-15-21(28)20-22(29)17(14-6-8-18(26)19(27)11-14)12-30-24(20)16-9-10-25(3,4)31-23(15)16/h5-6,8-12,26-28H,7H2,1-4H3

HIDE SMILES / InChI

Molecular Formula	C25H24O6
Molecular Weight	420.4545
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Primary Target	Pharmacology	Potency
histone deacetylase 1 Target ID: histone deacetylase Sources: https://www.ncbi.nlm.nih.gov/pubmed/17662606	Inhibitor 8504	1.0 µM [IC50]
Carbonic anhydrase 1 3 Target ID: P00915 Gene ID: 759.0 Gene Symbol: CA1 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/28338341	Inhibitor 8504	471.0 µM [Ki]
Carbonic anhydrase 2 5 Target ID: P00918 Gene ID: 760.0 Gene Symbol: CA2 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/28338341	Inhibitor 8504	235.7 µM [Ki]

PubMed

Title	Date	PubMed
Effect of pomiferin administration on kidney ischaemia-reperfusion injury in rats.	2010-06	21217877
Involvement of 1,25D3-MARRS (membrane associated, rapid response steroid-binding), a novel vitamin D receptor, in growth inhibition of breast cancer cells.	2010-03-10	20036234
Isolation, structure, and bioactivities of abiesadines A-Y, 25 new diterpenes from Abies georgei Orr.	2010-01-15	20022253
Examining the genomic influence of skin antioxidants in vitro.	2010	20706672
Cholinesterase inhibitory effects of the extracts and compounds of Maclura pomifera (Rafin.) Schneider.	2009-08	19394400
Electrochemical and spectrometric study of antioxidant activity of pomiferin, isopomiferin, osajin and catalposide.	2008-09-10	18597965
Outlook on Thailand's genomics and computational biology research and development.	2008-07-25	18654621
Pomiferin, histone deacetylase inhibitor isolated from the fruits of Maclura pomifera.	2007-09-01	17662606
[Examination of the antioxidative and antidiabetic effect of pomiferin in alloxan-induced diabetes mellitus in an experiment (a pilot study)].	2007-06	17867526
Effects of prenylated isoflavones osajin and pomiferin in premedication on heart ischemia-reperfusion.	2006-07	16936909
[Protective effects of the flavonoids osajin and pomiferin on heart ischemia-reperfusion].	2006-07	16921735
Proteomic profiling of cholangiocarcinoma cell line treated with pomiferin from Derris malaccensis.	2005-11	16220529
Antioxidative and EROD activities of osajin and pomiferin.	2004-03	15030927
Antioxidant isoflavones in Osage orange, Maclura pomifera (Raf.) Schneid.	2003-10-22	14558760
Pomiferin.	2003-03	12711784

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 19:55:23 GMT 2025` Edited by `admin` on `Mon Mar 31 19:55:23 GMT 2025`
Record UNII	74YIS40APM
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

POMIFERIN

Official Name

English

NSC-5113

Preferred Name

English

4H,8H-BENZO(1,2-B:3,4-B')DIPYRAN-4-ONE, 3-(3,4-DIHYDROXYPHENYL)-5-HYDROXY-8,8-DIMETHYL-6-(3-METHYL-2-BUTENYL)-

Systematic Name

English

3'-HYDROXYOSAJIN

Common Name

English

4H,8H-BENZO(1,2-B:3,4-B')DIPYRAN-4-ONE, 3-(3,4-DIHYDROXYPHENYL)-5-HYDROXY-8,8-DIMETHYL-6-(3-METHYL-2-BUTEN-1-YL)-

Systematic Name

English

Code System Code Type Description

FDA UNII

74YIS40APM