DIPOTASSIUM ASPARTATE

First marketed in 1921

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C4H5NO4.2K
Molecular Weight	209.2834
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[K+].[K+].N[C@@H](CC([O-])=O)C([O-])=O

InChI

InChIKey=IKALZAKZWHFNIC-JIZZDEOASA-L

InChI=1S/C4H7NO4.2K/c5-2(4(8)9)1-3(6)7;;/h2H,1,5H2,(H,6,7)(H,8,9);;/q;2*+1/p-2/t2-;;/m0../s1

HIDE SMILES / InChI

Molecular Formula	K
Molecular Weight	39.0983
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C4H5NO4
Molecular Weight	131.0868
Charge	-2
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.worldcat.org/title/fundamentals-of-biochemistry-life-at-the-molecular-level/oclc/910538334Advances in Protein Chemistry (1945), v.2, p.308, retrieved from: https://books.google.ru/books?id=QRyhIaEwrngC
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/15703381 | https://www.ncbi.nlm.nih.gov/pubmed/3814227 | https://www.ncbi.nlm.nih.gov/pubmed/16061593

Disodium aspartate is used in organic biosynthesis.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Potency
Isoaspartyl peptidase/L-asparaginase 8 Target ID: Q7L266 Gene ID: 80150.0 Gene Symbol: ASRGL1 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/3334241 \| https://www.ncbi.nlm.nih.gov/pubmed/7056352	Interacts 323
Glutamate [NMDA] receptor 125 Target ID: CHEMBL2094124 Sources: https://www.ncbi.nlm.nih.gov/pubmed/15703381	Activator 1430	18.4 µM [EC50]
Beta-glucuronidase 13 Target ID: P08236 Gene ID: 2990.0 Gene Symbol: GUSB Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/16061593	Inhibitor 8297

Conditions

Condition	Modality	Highest Phase	Product
Unknown 2578
Opiate abstinence syndrome 8 Sources: https://www.ncbi.nlm.nih.gov/pubmed/3814227	Primary	Natural Metabolite	Unknown Approved Use Unknown
Neonatal jaundice 8 Sources: https://www.ncbi.nlm.nih.gov/pubmed/16061593	Primary	Natural Metabolite	Unknown Approved Use Unknown

Doses

Dose	Population	Adverse events
6 g 1 times / day multiple, oral Highest studied dose Dose: 6 g, 1 times / day Route: oral Route: multiple Dose: 6 g, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/28841667	healthy, 22.4 ± 2.6 years n = 10 Health Status: healthy Age Group: 22.4 ± 2.6 years Sex: M Population Size: 10 Sources: https://pubmed.ncbi.nlm.nih.gov/28841667	Sources: https://pubmed.ncbi.nlm.nih.gov/28841667

Overview

CYP3A4	CYP2C9	CYP2D6	hERG

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
OAT1 599	Aspartoacylase 8 ASNS 8 ASCT2 12 ASCT1 8 SLC22A13 8 OAT1 326

Drug as perpetrator

Target	Modality	Activity	Metabolite	Clinical evidence
OAT1 603	inhibitor 3277 Sources: https://pubmed.ncbi.nlm.nih.gov/23255614/ Page: -	no

Drug as victim

Target	Modality	Activity
OAT1 326	substrate 3367 Sources: https://pubmed.ncbi.nlm.nih.gov/23255614/ Page: -	no
ASCT1 8	substrate 3367 Sources: https://onlinelibrary.wiley.com/doi/full/10.1046/j.1471-4159.2003.02063.x Page: -	yes
ASCT2 12	substrate 3367 Sources: https://onlinelibrary.wiley.com/doi/full/10.1046/j.1471-4159.2003.02063.x Page: -	yes
ASNS 8	substrate 3367 Sources: https://www.sciencedirect.com/science/article/pii/S1096719215300421 Page: -	yes
Aspartoacylase 8	substrate 3367 Sources: https://pubmed.ncbi.nlm.nih.gov/12706335/ Page: -	yes
SLC22A13 8	substrate 3367 Sources: https://pubmed.ncbi.nlm.nih.gov/24147638/ Page: -	yes

Sourcing

Vendor/Aggregator	ID	URL
ChEBI	CHEBI:22660	https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:22660
ChemicalBook	CB7233502	https://www.chemicalbook.com/ChemicalProductProperty_EN_CB7233502
MolPort	MolPort-001-781-456	https://www.molport.com/shop/molecule-link/MolPort-001-781-456
MolPort	MolPort-047-345-807	https://www.molport.com/shop/molecule-link/MolPort-047-345-807
eMolecules	478747	https://www.emolecules.com/cgi-bin/more?vid=478747

PubMed

Title	Date	PubMed
The biosynthesis of nicotinamide adenine dinucleotides in bacteria.	2001	11153263
Selective cleavage of BLM, the bloom syndrome protein, during apoptotic cell death.	2001 Apr 13	11154689
Expression pattern and gene characterization of asporin. a newly discovered member of the leucine-rich repeat protein family.	2001 Apr 13	11152695
Aging-induced changes in 24-h rhythms of mitogenic responses, lymphocyte subset populations and neurotransmitter and amino acid content in rat submaxillary lymph nodes during Freund's adjuvant arthritis.	2001 Feb	11226742
Protective effect of allopurinol on hepatic energy metabolism in ischemic and reperfused rat liver.	2001 Feb	11220638
Differences between GABA levels in Alzheimer's disease and Down syndrome with Alzheimer-like neuropathology.	2001 Feb	11218066
Factors associated with the risk of liver enzyme elevation in patients with type 2 diabetes treated with a thiazolidinedione.	2001 Feb	11213855
Nicotinic receptors mediate the release of amino acid neurotransmitters in cultured cortical neurons.	2001 Feb	11208670
Comparison of clinical, virologic and pathologic features in patients with acute hepatitis B and C.	2001 Feb	11207903
Increase of chemokine interferon-inducible protein-10 (IP-10) in the serum of patients with autoimmune liver diseases and increase of its mRNA expression in hepatocytes.	2001 Feb	11207658
Endotoxin clearance and its relation to hepatic and renal disturbances in rats with liver cirrhosis.	2001 Feb	11169075
Severe veno-occlusive disease after allogeneic bone marrow or peripheral stem cell transplantation--role of transjugular intrahepatic portosystemic shunt (TIPS).	2001 Feb	11169070
Extracellular amino acid levels measured with intracerebral microdialysis in the model of posttraumatic epilepsy induced by intracortical iron injection.	2001 Feb	11164702
Serum hepatic biochemical activity in two populations of workers exposed to styrene.	2001 Feb	11160987
Molecular mechanism of action at estrogen receptor alpha of a new clinically relevant antiestrogen (GW7604) related to tamoxifen.	2001 Feb	11159857
Central infusions of the recombinant human prolactin receptor antagonist, S179D-PRL, delay the onset of maternal behavior in steroid-primed, nulliparous female rats.	2001 Feb	11159845
Fluconazole for prophylaxis against candidal rectal colonization in the very low birth weight infant.	2001 Feb	11158461
A molecular variant of the APC gene at codon 1822: its association with diet, lifestyle, and risk of colon cancer.	2001 Feb 1	11221825
Protective effect of stiripentol on acetaminophen-induced hepatotoxicity in rat.	2001 Feb 1	11162779
Evidence for glutamate receptor mediated transmission at mechanoreceptors in the skin.	2001 Feb 12	11209947
Changes in striatal electroencephalography and neurochemistry induced by kainic acid seizures are modified by dopamine receptor antagonists.	2001 Feb 16	11226392
Evidence for microvesicular storage and release of glycine in rodent pinealocytes.	2001 Feb 16	11166946
Coagulation profile, hepatic function, and hemodynamics following Fontan-type operations.	2001 Jan	11233399
Comparison of the efficacy and tolerability of fluvastatin extended-release and immediate-release formulations in the treatment of primary hypercholesterolemia: a randomized trial.	2001 Jan	11219479
Characterization of peptide substrates and viral enzyme that affect the cleavage site specificity of the human spumaretrovirus proteinase.	2001 Jan	11210941
Relationship between crevicular aspartate aminotransferase levels and periodontal disease progression.	2001 Jan	11210069
Dietary cancer risk from conditional cancerogens (tumor promoters) in produce of livestock fed on species of spurge (Euphorbiaceae). IV. Toxicologic and pathophysiologic observations in lactating goats and their suckling kids fed on the irritant herbs Euphorbia nubica and Euphorbia helioscopia: an etiologic model for investigations on the putative risk of cancer by consumption of food p.	2001 Jan	11206269
Exercise improved accumulation of visceral fat and simultaneously impaired endothelium-dependent relaxation in old rats.	2001 Jan	11201252
Use of intraosseous blood for repeated hematologic and biochemical analyses in healthy pigs.	2001 Jan	11197559
Oxygen free radical generation in healthy blood donors and cardiac patients: the protective effect of allopurinol.	2001 Jan	11192309
The effect of amino acid-modifying reagents on chloroplast protein import and the formation of early import intermediates.	2001 Jan	11181713
Effects of aflatoxin and carotenoids on growth performance and immune response in mule ducklings.	2001 Jan	11166670
Lactococcus lactis LM0230 contains a single aminotransferase involved in aspartate biosynthesis, which is essential for growth in milk.	2001 Jan	11160815
A comparison of the effect of nitroparacetamol and paracetamol on liver injury.	2001 Jan	11156555
Redistribution of neuroactive amino acids in hippocampus and striatum during hypoglycemia: a quantitative immunogold study.	2001 Jan	11149667
Excitatory amino acid concentrations in ventricular cerebrospinal fluid after severe traumatic brain injury in infants and children: the role of child abuse.	2001 Jan	11148507
Microdialysis study of amino acid neurotransmitters in the spinal dorsal horn of patients undergoing microsurgical dorsal root entry zone lesioning. Technical note.	2001 Jan	11147857
Pregnancy complicated by pre-eclampsia-eclampsia with HELLP syndrome.	2001 Jan	11146072
Studies on the effects of lactate transport inhibition, pyruvate, glucose and glutamine on amino acid, lactate and glucose release from the ischemic rat cerebral cortex.	2001 Jan	11145998
Possible linkage between glutamate transporter and mitogen-activated protein kinase cascade in cultured rat cortical astrocytes.	2001 Jan	11145995
Propylene glycol toxicosis in a llama.	2001 Jan 15	11195832
Strain is more important than electrostatic interaction in controlling the pKa of the catalytic group in aspartate aminotransferase.	2001 Jan 16	11148029
Inhibition of evoked glutamate release by the neuroprotective 5-HT(1A) receptor agonist BAY x 3702 in vitro and in vivo.	2001 Jan 5	11146061
Substrate translocation kinetics of excitatory amino acid carrier 1 probed with laser-pulse photolysis of a new photolabile precursor of D-aspartic acid.	2001 Jan 9	11141075
The effect of repeated gavage doses of fumonisin B1 on the sphinganine and sphingosine levels in vervet monkeys.	2001 Jul	11223085
Association between serum concentrations of hexachlorobenzene and polychlorobiphenyls with thyroid hormone and liver enzymes in a sample of the general population.	2001 Mar	11171930
Recruitment, activation and retention of caspases-9 and -3 by Apaf-1 apoptosome and associated XIAP complexes.	2001 Mar 1	11230124
Site-directed mutations in the mitochondrially encoded subunits I and III of yeast cytochrome oxidase.	2001 Mar 1	11171120
Differential effects of endomorphin-1 and -2 on amphetamine sensitization: neurochemical and behavioral aspects.	2001 Mar 1	11169772
Crystal structure of Lyme disease antigen outer surface protein C from Borrelia burgdorferi.	2001 Mar 30	11139584

Patents

Sample Use Guides

In Vivo Use Guide

Aspartic acid is a nutrient component found in animal and vegetable sources. In clinical trials to alleviate opioid abstinence it was administered orally.

Route of Administration: Oral

In Vitro Use Guide

Activation of recombinant NMDA receptors was measured using two-electrode voltage clamp. Current and voltage electrodes were made from thin-walled borosilicate glass using a PP-830 electrode puller and when filled with 3 M KCl, possessed resistances of between 0.5 and 1.5 MΩ. Oocytes were voltage-clamped at potentials of -40 mV. Aspartate was able to activate wild type NR1/NR2A NMDA receptors with EC50 of 18.4 uM.

Substance Class	Chemical Created by `admin` on `Sat Dec 16 01:50:02 GMT 2023` Edited by `admin` on `Sat Dec 16 01:50:02 GMT 2023`
Record UNII	74X989P9A6
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DIPOTASSIUM ASPARTATE

Official Name

English

KALIUM L-ASPARTATE

Systematic Name

English

L-ASPARTIC ACID, POTASSIUM SALT (1:2)

Common Name

English

Kalium l-aspartate [WHO-DD]

Common Name

English

L-ASPARTIC ACID, DIPOTASSIUM SALT

Common Name

English

ASPARTIC ACID, DIPOTASSIUM SALT, L-

Common Name

English

DIPOTASSIUM ASPARTATE [INCI]

Common Name

English

DIPOTASSIUM ASPARTATE ANHYDROUS

Common Name

English

ASPARTIC ACID, DIPOTASSIUM SALT

Common Name

English

Code System Code Type Description

ECHA (EC/EINECS)

217-892-4