Tarlatamab

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 20:58:53 GMT 2025` Edited by `admin` on `Tue Apr 01 20:58:53 GMT 2025`
Protein Type	SINGLE CHAIN ANTIBODY
Protein Sub Type	BISPECIFIC T CELL ENGAGER
Record UNII	74X82ST8Q1
Record Status	`Validated (UNII)`
Record Version

Download

Related Record	Type

Name

Type

Language

Tarlatamab

Official Name

English

Immunoglobulin, anti-(human notch ligand DLL3) (human monoclonal daeldhwzv-1 single-chain variable fragment VH1-(GGGGS)3-VL1) fusion protein with peptide linker (GGGGS) fusion protein with immunoglobulin anti-(human CD3 antigen ?-chain) (human monoclonal

Preferred Name

English

AMG-757

Code

English

Immunoglobulin scFv-scFv-scFc, anti-[Homo sapiens DLL3 (delta-like ligand 3)] and anti-[Homo sapiens CD3E (CD3 epsilon, Leu-4)], monoclonal antibody single chain (scFv)2-scFc, bispecific; IG single chain scFv-scFv-scFc, antiDLL3 and anti-CD3E (1-982) [sc

Common Name

English

tarlatamab [INN]

Common Name

English

TARLATAMAB [USAN]

Common Name

English

Tarlatamab [WHO-DD]

Common Name

English

AMG757

Code

English

Classification Tree Code System Code

FDA ORPHAN DRUG

665418

Created by admin on Tue Apr 01 20:58:53 GMT 2025 , Edited by admin on Tue Apr 01 20:58:53 GMT 2025

Code System Code Type Description

SMS_ID

300000032570

Created by admin on Tue Apr 01 20:58:53 GMT 2025 , Edited by admin on Tue Apr 01 20:58:53 GMT 2025

PRIMARY

FDA UNII

74X82ST8Q1

Created by admin on Tue Apr 01 20:58:53 GMT 2025 , Edited by admin on Tue Apr 01 20:58:53 GMT 2025

PRIMARY

INN

11420

Created by admin on Tue Apr 01 20:58:53 GMT 2025 , Edited by admin on Tue Apr 01 20:58:53 GMT 2025

PRIMARY

CAS

2307488-83-9

Created by admin on Tue Apr 01 20:58:53 GMT 2025 , Edited by admin on Tue Apr 01 20:58:53 GMT 2025

PRIMARY

DAILYMED

74X82ST8Q1

Created by admin on Tue Apr 01 20:58:53 GMT 2025 , Edited by admin on Tue Apr 01 20:58:53 GMT 2025

PRIMARY

NCI_THESAURUS

C175858

Created by admin on Tue Apr 01 20:58:53 GMT 2025 , Edited by admin on Tue Apr 01 20:58:53 GMT 2025

PRIMARY

USAN

JK-173

Created by admin on Tue Apr 01 20:58:53 GMT 2025 , Edited by admin on Tue Apr 01 20:58:53 GMT 2025

PRIMARY

From	To
1_22	1_95
1_44	1_234
1_156	1_222
1_269	1_345
1_409	1_477
1_506	1_761
1_509	1_764
1_541	1_601
1_572	1_582
1_647	1_705
1_796	1_856
1_827	1_837
1_902	1_960

Related Record Type Details


					Y776670LBR

.DELTA.-LIKE PROTEIN 3

TARGET -> ACTIVATOR

Interaction Type:

BINDING

Qualification:

Kd

Amount:


					1U72JD9DDZ

T-CELL SURFACE GLYCOPROTEIN CD3 EPSILON CHAIN

TARGET -> ACTIVATOR

Interaction Type:

BINDING

Qualification:

Kd

Amount:

Tarlatamab-DLLE

SUB_CONCEPT->SUBSTANCE

Amount:

Related Record Type Details


					74X82ST8Q1

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_982]	C-TERMINUS			LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL