PROPIDIUM

Details

Stereochemistry	ACHIRAL
Molecular Formula	C27H34N4
Molecular Weight	414.5857
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	2

SHOW SMILES / InChI

Structure Search

SMILES

CC[N+](C)(CC)CCC[N+]1=C(C2=CC=CC=C2)C3=C(C=CC(N)=C3)C4=C1C=C(N)C=C4

InChI

InChIKey=ZDWVWKDAWBGPDN-UHFFFAOYSA-O

InChI=1S/C27H33N4/c1-4-31(3,5-2)17-9-16-30-26-19-22(29)13-15-24(26)23-14-12-21(28)18-25(23)27(30)20-10-7-6-8-11-20/h6-8,10-15,18-19,29H,4-5,9,16-17,28H2,1-3H3/q+1/p+1

HIDE SMILES / InChI

Molecular Formula	C27H33N4
Molecular Weight	413.5777
Charge	1
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Acetylcholinesterase 207 Target ID: CHEMBL220 Sources: https://www.ncbi.nlm.nih.gov/pubmed/15633997\| https://www.ncbi.nlm.nih.gov/pubmed/1125207	Inhibitor 8297
DNA 278 Target ID: DNA Sources: https://www.ncbi.nlm.nih.gov/pubmed/15633997	Binding Agent 1064

PubMed

Title	Date	PubMed
A novel role for interleukin-18 in human natural killer cell death: high serum levels and low natural killer cell numbers in patients with systemic autoimmune diseases.	2001 Apr	11315928
Verocytotoxin-induced apoptosis of human microvascular endothelial cells.	2001 Apr	11274238
The metabotropic glutamate receptor agonist 1S,3R-ACPD stimulates and modulates NMDA receptor mediated excitotoxicity in organotypic hippocampal slice cultures.	2001 Apr 13	11292452
TNF-alpha stimulates caspase-3 activation and apoptotic cell death in primary septo-hippocampal cultures.	2001 Apr 15	11288141
Brief exposure to low-pH stress causes irreversible damage to the growing root in Arabidopsis thaliana: pectin-Ca interaction may play an important role in proton rhizotoxicity.	2001 Feb	11283181
Cytotoxicity of anti-CD64-ricin a chain immunotoxin against human acute myeloid leukemia cells in vitro and in SCID mice.	2001 Feb	11276363
The cyclic AMP/PKA signal pathway is required for initiation of spore germination in Schizosaccharomyces pombe.	2001 Feb	11180454
Orphenadrine prevents 3-nitropropionic acid-induced neurotoxicity in vitro and in vivo.	2001 Feb	11159722
Suramin prevents cerebellar granule cell-death induced by dequalinium.	2001 Feb	11137882
Ebselen prevents excitotoxicity provoked by glutamate in rat cerebellar granule neurons.	2001 Feb 23	11165774
Ceramide generation occurring during 7beta-hydroxycholesterol- and 7-ketocholesterol-induced apoptosis is caspase independent and is not required to trigger cell death.	2001 Jan	11313706
Qian-Kun-Nin, a Chinese herbal medicine formulation, attenuates mitochondrial oxidant stress in cardiomyocytes.	2001 Jan	11137349
NASA/American Cancer Society High-Resolution Flow Cytometry Project - III. Multiparametric analysis of DNA content and electronic nuclear volume in human solid tumors.	2001 Jan 1	11122480
Protection of boar spermatozoa from cold shock damage by 2-hydroxypropyl-beta-cyclodextrin.	2001 Jan 15	11233787
Cryopreservation of equine embryos by open pulled straw, cryoloop, or conventional slow cooling methods.	2001 Jan 15	11233786
Encystation in Acanthamoeba castellanii: development of biocide resistance.	2001 Jan-Feb	11249185
Fluorescent probes and flow cytometry to assess rat sperm integrity and mitochondrial function.	2001 Jan-Feb	11137373
Thioflavin T is a fluorescent probe of the acetylcholinesterase peripheral site that reveals conformational interactions between the peripheral and acylation sites.	2001 Jun 29	11313335
Campylobacter upsaliensis exerts a cytolethal distending toxin effect on HeLa cells and T lymphocytes.	2001 Mar	11238981
Transient vs. prolonged histone hyperacetylation: effects on colon cancer cell growth, differentiation, and apoptosis.	2001 Mar	11171632
Quantitative analysis of specific mRNA species in minute cell samples by RT-PCR and flow cytometry.	2001 Mar 1	11226479
Flow cytometric assay for evaluation of the effects of cell density on cytotoxicity and induction of apoptosis.	2001 Mar 1	11170107
Effect of an acute glucose overload on Islet cell morphology and secretory function in the toad.	2001 May	11316418
Clostridium perfringens epsilon toxin induces a rapid change of cell membrane permeability to ions and forms channels in artificial lipid bilayers.	2001 May 11	11278669

Substance Class	Chemical Created by `admin` on `Fri Dec 15 18:10:19 GMT 2023` Edited by `admin` on `Fri Dec 15 18:10:19 GMT 2023`
Record UNII	74NX23J96Y
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PROPIDIUM

Common Name

English

PROPIDIUM ION

Common Name

English

PROPIDIUM CATION

Common Name

English

PHENANTHRIDINIUM, 3,8-DIAMINO-5-(3-(DIETHYLMETHYLAMMONIO)PROPYL)-6-PHENYL-

Systematic Name

English

Code System Code Type Description

EPA CompTox

DTXSID20189583