OMFILOCTOCOG ALFA

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Investigational

Investigational

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 06:48:11 GMT 2025` Edited by `admin` on `Wed Apr 02 06:48:11 GMT 2025`
Protein Type	FC FUSION PROTEIN
Protein Sub Type
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	74D9ZOJ6IR
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

OMFILOCTOCOG ALFA

Official Name

English

omfiloctocog alfa [INN]

Preferred Name

English

1-740-BLOOD COAGULATION FACTOR VIII (RECOMBINANT HUMAN SCT800 HEAVY CHAIN) FUSION PROTEIN WITH HUMAN BLOOD COAGULATION FACTOR VIII B DOMAIN FRAGMENT (14-AMINO ACID LINKER) FUSION PROTEIN WITH BLOOD COAGULATION FACTOR VIII (RECOMBINANT HUMAN SCT800 LIGHT

Common Name

English

HUMAN COAGULATION FACTOR VIII (FVIII, ANTIHEMOPHILIC FACTOR, AHF, PROCOAGULANT COMPONENT) WITH DELETED B-DOMAIN (746-1639)-SEQUENCE: SINGLE-CHAIN RECOMBINANT FVIII COMPOSED OF DOMAINS A1-A1-A2-A2 (1-740), THE B-DOMAIN N-AND C-TERMINAL FRAGMENTS (741-745)

Common Name

English

SCT800

Code

English

Omfiloctocog alfa [WHO-DD]

Common Name

English

SCT-800

Code

English

Code System Code Type Description

SMS_ID

300000024111

Created by admin on Wed Apr 02 06:48:11 GMT 2025 , Edited by admin on Wed Apr 02 06:48:11 GMT 2025

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NCI_THESAURUS

C175177

Created by admin on Wed Apr 02 06:48:11 GMT 2025 , Edited by admin on Wed Apr 02 06:48:11 GMT 2025

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FDA UNII

74D9ZOJ6IR

Created by admin on Wed Apr 02 06:48:11 GMT 2025 , Edited by admin on Wed Apr 02 06:48:11 GMT 2025

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INN

11213

Created by admin on Wed Apr 02 06:48:11 GMT 2025 , Edited by admin on Wed Apr 02 06:48:11 GMT 2025

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CLINICAL_TRIALS.GOV

NCT02888223

Created by admin on Wed Apr 02 06:48:11 GMT 2025 , Edited by admin on Wed Apr 02 06:48:11 GMT 2025

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CAS

2249927-58-8

Created by admin on Wed Apr 02 06:48:11 GMT 2025 , Edited by admin on Wed Apr 02 06:48:11 GMT 2025

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From	To
1_153	1_179
1_248	1_329
1_528	1_554
1_630	1_711
1_938	1_964
1_1005	1_1009
1_1280	1_1432
1_1127	1_1275

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_41
N	1_239
N	1_916
N	1_1224

Related Record Type Details


					74D9ZOJ6IR

OMFILOCTOCOG ALFA

ACTIVE MOIETY

Comments:

Blood coagulation factor replacements

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_346] [1_718] [1_719] [1_723] [1_770] [1_786]	SITE_SPECIFIC			TYROSINE O-SULFATE	29166358BF

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL