LY-2979165

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C13H17N5O5S
Molecular Weight	355.37
Optical Activity	UNSPECIFIED
Defined Stereocenters	6 / 6
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@]12[C@H](C(O)=O)[C@@]1([H])[C@](C[C@H]2SC3=NN=CN3)(NC(=O)[C@H](C)N)C(O)=O

InChI

InChIKey=BBGHHIUQOKQCBW-LDZWZCGGSA-N

InChI=1S/C13H17N5O5S/c1-4(14)9(19)17-13(11(22)23)2-5(24-12-15-3-16-18-12)6-7(8(6)13)10(20)21/h3-8H,2,14H2,1H3,(H,17,19)(H,20,21)(H,22,23)(H,15,16,18)/t4-,5+,6-,7-,8-,13-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C13H17N5O5S
Molecular Weight	355.37
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	6 / 6
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Metabotropic glutamate receptor 2 24 Target ID: CHEMBL5137 Sources: https://www.ncbi.nlm.nih.gov/pubmed/29564482 \| https://adisinsight.springer.com/drugs/800033329	Agonist 2678
Metabotropic glutamate receptor 3 16 Target ID: CHEMBL2888 Sources: https://adisinsight.springer.com/drugs/800033329	Agonist 2678

PubMed

Title	Date	PubMed
Evaluation of single and multiple doses of a novel mGlu2 agonist, a potential antipsychotic therapy, in healthy subjects.	2017 Aug	28156011
Group II metabotropic glutamate receptor agonist prodrugs LY2979165 and LY2140023 attenuate the functional imaging response to ketamine in healthy subjects.	2018 Jul	29564482

Substance Class	Chemical Created by `admin` on `Sat Dec 16 06:39:31 GMT 2023` Edited by `admin` on `Sat Dec 16 06:39:31 GMT 2023`
Record UNII	739DM5514X
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

LY-2979165

Code

English

HY-13239

Code

English

BICYCLO(3.1.0)HEXANE-2,6-DICARBOXYLIC ACID, 2-(((2S)-2-AMINO-1-OXOPROPYL)AMINO)-4-(1H-1,2,4-TRIAZOL-5-YLTHIO)-, (1R,2S,4R,5R,6R)-

Systematic Name

English

Code System Code Type Description

ChEMBL

CHEMBL3544939