PRAZEPINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H24N2
Molecular Weight	280.4073
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN(C)CCCN1CC2=CC=CC=C2CC3=CC=CC=C13

InChI

InChIKey=UKCVXGBHVGMFCN-UHFFFAOYSA-N

InChI=1S/C19H24N2/c1-20(2)12-7-13-21-15-18-10-4-3-8-16(18)14-17-9-5-6-11-19(17)21/h3-6,8-11H,7,12-15H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C19H24N2
Molecular Weight	280.4073
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: Elks, J. (2014) The Dictionary of Drugs: Chemical Data, page 1010, retrieved from: https://books.google.ru/books?id=0vXTBwAAQBAJ | https://howlingpixel.com/i-en/Tricyclic_antidepressant | Rocha e Silva, M. (2013) Histamine II and Anti-Histaminics, page 201, retrieved from: https://books.google.ru/books?id=aZXzCAAAQBAJ

Prazepine is a tricyclic antidepressant (TCA). Propazepine is sometimes confused with imipramine, which has the central ring nitrogen in a different location. Propazepine appears to never have actually been used as a tricyclic antidepressant outside of initial medical tests. Prazepine showed potent antihistaminic properties.

Approval Year

PubMed

Title	Date	PubMed
[Comparison of pharmacological properties of propazepine and imipramine].	1961 May	14473038
[Comparative studies on the effect of Imipramine and Propazepine by electrophysiological methods on animals with implanted electrodes].	1962	13867184
Electrophysiological comparison of the action of imipramine and propazepine.	1962 Dec 12	13967414
[EFFECT OF IPRONIAZID, PROPAZEPINE, RESERPINE AND THEIR COMBINATIONS ON THE ORIENTATION REACTION AND CONDITIONED DEFENSE REACTION IN RATS].	1964	14179381
Serotonin level in human and animal thrombocytes after imipramine and propazepine administration.	1965 Aug	5882104
[Behavior pharmacology of maprotiline, a new antidepressant].	1975 Nov	1240830
Painful ejaculation associated with antidepressants in four patients.	1991 Nov	1744063
Block of rat brain recombinant SK channels by tricyclic antidepressants and related compounds.	2000 Jul 28	10915830
Prescription of QT-prolonging drugs in a cohort of about 5 million outpatients.	2003 Feb 1	12586234
[Hypnotherapy in the treatment of refractory nocturnal enuresis].	2004 Feb 19	14983195
Long-term imipramine withdrawal induces a depressive-like behaviour in the forced swimming test.	2004 May 10	15145707
Evaluation of fresh and cryopreserved hepatocytes as in vitro drug metabolism tools for the prediction of metabolic clearance.	2004 Nov	15286053
[Trazodone for the treatment of behavioral and psychological symptoms of dementia (BPSD) in Alzheimer's disease: a retrospective study focused on the aggression and negativism in caregiving situations].	2006 Jun	16856516
In vitro detection of drug-induced phospholipidosis using gene expression and fluorescent phospholipid based methodologies.	2007 Sep	17567588
Hereditary diffuse gastric cancer: association with lobular breast cancer.	2008	18046629
Manifestation of psychiatric behaviors in a mouse model of griseofulvin-induced hepatic porphyria.	2008 Dec	19043281
Temporal expression of brain-derived neurotrophic factor (BDNF) mRNA in the rat hippocampus after treatment with selective and mixed monoaminergic antidepressants.	2008 Jan 14	17950272

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:49:07 GMT 2023` Edited by `admin` on `Fri Dec 15 15:49:07 GMT 2023`
Record UNII	72O4809PU1
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PRAZEPINE

Official Name

English

prazepine [INN]

Common Name

English

NSC-172129

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C265