RILTOZINAMERAN

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Sat Dec 16 18:09:18 UTC 2023` Edited by `admin` on `Sat Dec 16 18:09:18 UTC 2023`
Nucleic Acid Subtype
Record UNII	72JR7XDV94
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

RILTOZINAMERAN

Official Name

English

riltozinameran [INN]

Common Name

English

Riltozinameran [WHO-DD]

Common Name

English

BNT162B2_B.1.1.529

Code

English

RNA (RECOMBINANT 5'-(1,2-((3'-O-METHYL)M7G-(5'->5')-PPP-AM))-CAPPED ALL URIDINE->N1-METHYLPSEUDOURIDINE-SUBSTITUTED SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 SPIKE GLYCOPROTEIN SECRETORY SIGNAL PEPTIDE PLUS CODON-OPTIMIZED SPIKE GLYCOPROTEIN B.1.1.

Common Name

English

MESSENGER RNA (MRNA), 5'-CAPPED, ENCODING A FULL-LENGTH, CODON-OPTIMISED PRE-FUSION STABILISED CONFORMATION VARIANT (K983P AND V984P) OF THE SARS-COV-2 (SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; OMICRON VARIANT AND B.1.1.529 AND HCOV-19/BOTSWANA/R

Common Name

English

Code System Code Type Description

FDA UNII

72JR7XDV94

Created by admin on Sat Dec 16 18:09:18 UTC 2023 , Edited by admin on Sat Dec 16 18:09:18 UTC 2023

PRIMARY

SMS_ID

300000042045

Created by admin on Sat Dec 16 18:09:18 UTC 2023 , Edited by admin on Sat Dec 16 18:09:18 UTC 2023

PRIMARY

INN

12510

Created by admin on Sat Dec 16 18:09:18 UTC 2023 , Edited by admin on Sat Dec 16 18:09:18 UTC 2023

PRIMARY

NCI_THESAURUS

C188525

Created by admin on Sat Dec 16 18:09:18 UTC 2023 , Edited by admin on Sat Dec 16 18:09:18 UTC 2023

PRIMARY

CAS

2749948-25-0

Created by admin on Sat Dec 16 18:09:18 UTC 2023 , Edited by admin on Sat Dec 16 18:09:18 UTC 2023

PRIMARY

Sugar	Site Range	Site Count
2'-O-Methyl-Ribose	1_1	1 / 4274
D-Ribose (RNA)	1_2-1_4274	4273 / 4274

Linkage	Site Range	Site Count
Phosphate	1_2-1_4274	4273 / 4273

Related Record Type Details


					VV9NW7QG2X

SARS-COV2 B.1.1.529 VARIANT

TARGET ORGANISM->VACCINE ANTIGEN

Amount:

Related Record Type Details


					72JR7XDV94

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOSIDE_SUBSTITUTION		RESIDUE_SPECIFIC	U		N1-METHYLPSEUDOURIDINE	09RAD4M6WF
NUCLEOTIDE SUBSTITUTION	[1_1]	SITE_SPECIFIC			m2-7,3’-OGppp(m1-2’-O)Ap mRNA CAP	VNP8CZY34V