NARINGIN DIHYDROCHALCONE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C27H34O14
Molecular Weight	582.5505
Optical Activity	UNSPECIFIED
Defined Stereocenters	10 / 10
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C[C@@H]1O[C@@H](O[C@@H]2[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]2OC3=CC(O)=C(C(=O)CCC4=CC=C(O)C=C4)C(O)=C3)[C@H](O)[C@H](O)[C@H]1O

InChI

InChIKey=CWBZAESOUBENAP-QVNVHUMTSA-N

InChI=1S/C27H34O14/c1-11-20(33)22(35)24(37)26(38-11)41-25-23(36)21(34)18(10-28)40-27(25)39-14-8-16(31)19(17(32)9-14)15(30)7-4-12-2-5-13(29)6-3-12/h2-3,5-6,8-9,11,18,20-29,31-37H,4,7,10H2,1H3/t11-,18+,20-,21+,22+,23-,24+,25+,26-,27+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C27H34O14
Molecular Weight	582.5505
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	10 / 10
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/17666819
Curator's Comment: description was created based on several sources, including http://www.gmp-factory.com/herbal-food-additives/natural-sweeteners/naringin-dihydrochalcone.html | https://www.ncbi.nlm.nih.gov/pubmed/7473560

Naringin Dihydrochalcone (Naringin DC) is a new-style sweetening agent and an artificial sweetener derived from naringin. It is 500-700 times sweeter than sucrose. Due to its many advantages like high sweet taste, low caloric, innocuity and safety, it can be used in edible, medicine and commodity trade. And because it tastes cleanlily, has long aftertaste and special faint scent and owns fine virtue of shielding bitterness, Naringin dihydrochalcone is in particular used for milky goods, fattiness and grease, freezed foodstuff, machining vegetable, jelly, comfiture, nonalcohol beverage, chewing gum, toothpaste and troche. Besides, it can substitute sugar for decreasing body absorption to sugar. It is really a evangel for fat person and patients who can not eat sugar.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2578

PubMed

Title	Date	PubMed
Structure-taste correlations in sweet dihydrochalcone, sweet dihydroisocoumarin, and bitter flavone compounds.	1995 Oct 13	7473560
Hypouricemic action of selected flavonoids in mice: structure-activity relationships.	2007 Aug	17666819

Patents

Sample Use Guides

In Vivo Use Guide

Naringin dihydrochalcone was dissolved or suspended in 0.5% carboxymethylcellulose-Na. Naringin dihydrochalcone at 50 and 100 mg/kg body weight was orally given to the mice once a day for three consecutive days. Mice were fasted for 2 h before drug administration.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Sat Dec 16 02:14:57 GMT 2023` Edited by `admin` on `Sat Dec 16 02:14:57 GMT 2023`
Record UNII	7233QDO0QW
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NARINGIN DIHYDROCHALCONE

Common Name

English

FEMA NO. 4495

Code

English

1-PROPANONE, 1-(4-((2-O-(6-DEOXY-.ALPHA.-L-MANNOPYRANOSYL)-.BETA.-D-GLUCOPYRANOSYL)OXY)-2,6-DIHYDROXYPHENYL)-3-(4-HYDROXYPHENYL)-

Common Name

English

GLUCOPYRANOSIDE, 3,5-DIHYDROXY-4-(P-HYDROXYHYDROCINNAMOYL)PHENYL 2-O-(6-DEOXY-.ALPHA.-L-MANNOPYRANOSYL)-, .BETA.-D-

Common Name

English

PHLORETIN, 4'-(2-O-.ALPHA.-L-RHAMNO-.BETA.-D-GLUCOPYRANOSIDE)

Common Name

English

Code System Code Type Description

PUBCHEM

9894584