SPHINGOSINE 1-PHOSPHATE RECEPTOR 4

Approval Year

Substance Class	Protein Created by `admin` on `Sat Dec 16 14:56:22 GMT 2023` Edited by `admin` on `Sat Dec 16 14:56:22 GMT 2023`
Protein Type	RECEPTOR
Protein Sub Type
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	71TF1I38OY
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

SPHINGOSINE 1-PHOSPHATE RECEPTOR 4

Common Name

English

SPHINGOSINE 1-PHOSPHATE RECEPTOR EDG-6

Common Name

English

S1PR4

Common Name

English

S1P4

Common Name

English

S1P RECEPTOR EDG-6

Common Name

English

S1P RECEPTOR 4

Common Name

English

ENDOTHELIAL DIFFERENTIATION G-PROTEIN COUPLED RECEPTOR 6

Common Name

English

Code System Code Type Description

UNIPROT

O95977

Created by admin on Sat Dec 16 14:56:23 GMT 2023 , Edited by admin on Sat Dec 16 14:56:23 GMT 2023

PRIMARY

CAS

1695594-32-1

Created by admin on Sat Dec 16 14:56:23 GMT 2023 , Edited by admin on Sat Dec 16 14:56:23 GMT 2023

PRIMARY

FDA UNII

71TF1I38OY

Created by admin on Sat Dec 16 14:56:23 GMT 2023 , Edited by admin on Sat Dec 16 14:56:23 GMT 2023

PRIMARY

Glycosylation Type

HUMAN

Glycosylation Link Type	Site
N	1_2
N	1_30

Related Record Type Details


					92YDM6122J

FINGOLIMOD PHOSPHATE ESTER, (S)-

AGONIST -> TARGET

Comments:

Phase2 clinical trial results of siponimod and ceralifimod suggest that S1P3 and S1P4 targeting are not needed for therapeutic efficacy.

Amount:


					6WH8495MMH

ETRASIMOD

PARTIAL AGONIST->TARGET

Comments:

Relative efficacY of 63% of S1P1 activity

Qualification:

EC50

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT	CHEMICAL