Approval Year
| Substance Class |
Protein
Created
by
admin
on
Edited
Wed Apr 02 02:03:22 GMT 2025
by
admin
on
Wed Apr 02 02:03:22 GMT 2025
|
| Protein Type | RECEPTOR |
| Protein Sub Type | |
| Sequence Origin | HUMAN |
| Sequence Type | COMPLETE |
| Record UNII |
71TF1I38OY
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| Record Status |
Validated (UNII)
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| Record Version |
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-
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| Name | Type | Language | ||
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Common Name | English | ||
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Preferred Name | English | ||
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Common Name | English | ||
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Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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O95977
Created by
admin on Wed Apr 02 02:03:22 GMT 2025 , Edited by admin on Wed Apr 02 02:03:22 GMT 2025
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PRIMARY | |||
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1695594-32-1
Created by
admin on Wed Apr 02 02:03:22 GMT 2025 , Edited by admin on Wed Apr 02 02:03:22 GMT 2025
|
PRIMARY | |||
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71TF1I38OY
Created by
admin on Wed Apr 02 02:03:22 GMT 2025 , Edited by admin on Wed Apr 02 02:03:22 GMT 2025
|
PRIMARY |
| Glycosylation Type | HUMAN |
| Glycosylation Link Type | Site |
|---|---|
| N | 1_2 |
| N | 1_30 |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
AGONIST -> TARGET |
Phase2 clinical trial results of siponimod and ceralifimod suggest that S1P3 and S1P4 targeting are not needed for therapeutic efficacy.
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PARTIAL AGONIST->TARGET |
Relative efficacY of 63% of S1P1 activity
EC50
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WEAK AGONIST->OFF TARGET |
Chinese Hamster Ovary (CHO) cells, overexpressing human S1P4 receptor (35S)-GTP-S incorporation assays.
EC50
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AGONIST -> TARGET |
EC50
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Structural Modifications
| Modification Type | Location Site | Location Type | Residue Modified | Extent | Fragment Name | Fragment Approval |
|---|---|---|---|---|---|---|
| AMINO_ACID_SUBSTITUTION | [1_323] | SITE_SPECIFIC | S-PALMITOYL CYSTEINE | 08WQ73S7SV |
| Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
|---|---|---|---|---|---|---|
| MOL_WEIGHT | CHEMICAL |
|