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Approval Year

Unknown
149124
Substance Class Protein
Created
by admin
on Tue Apr 01 22:37:29 GMT 2025
Edited
by admin
on Tue Apr 01 22:37:29 GMT 2025
Protein Type MONOCLONAL ANTIBODY CONJUGATE
Protein Sub Type IGG1
Sequence Origin HUMANIZED MOUSE
Sequence Type COMPLETE
Record UNII
71KV7F609O
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MIPASETAMAB UZOPTIRINE
INN   USAN  
Official Name English
ADCT-601
Preferred Name English
IMMUNOGLOBULIN G1-KAPPA, ANTI-(HOMO SAPIENS TYROSINE-PROTEIN KINASE RECEPTOR UFO (AXL ONCOGENE; EC=2.7.10.1)); HUMANIZED MONOCLONAL ANTIBODY CONJUGATED TO THE PYRROLOBENZODIAZEPINE (PDB) DIMER, SG3199; .GAMMA.1 HEAVY CHAIN HUMANIZED (1-451) (VH HUMANIZED
Common Name English
IMMUNOGLOBULIN G1-KAPPA, ANTI-(HOMO SAPIENS AXL (AXL RECEPTOR TYROSINE KINASE, TYROSINE-PROTEIN KINASE RECEPTOR UFO)), HUMANIZED MONOCLONAL ANTIBODY CONJUGATED TO THE PYRROLOBENZODIAZEPINE (PBD) DIMER, SG3199 (MIPASETAMAB UZOPTIRINE)
Common Name English
MIPASETAMAB UZOPTIRINE [USAN]
Common Name English
mipasetamab uzoptirine [INN]
Common Name English
Mipasetamab uzoptirine [WHO-DD]
Common Name English
IMMUNOGLOBULIN G1, ANTI-(HUMAN RECEPTOR TYROSINE KINASE AXL) (HUMAN-MUS MUSCULUS MONOCLONAL 1H12 .GAMMA.1-CHAIN), DISULFIDE WITH HUMAN-MUS MUSCULUS MONOCLONAL 1H12 .KAPPA.-CHAIN, DIMER, 302,302'-BIS(N-(O-2-(ACETYLAMINO)-6-AZIDO-2,6-DIDEOXY-.BETA.-D-GALAC
Common Name English
Code System Code Type Description
SMS_ID
300000032585
Created by admin on Tue Apr 01 22:37:29 GMT 2025 , Edited by admin on Tue Apr 01 22:37:29 GMT 2025
PRIMARY
INN
11416
Created by admin on Tue Apr 01 22:37:29 GMT 2025 , Edited by admin on Tue Apr 01 22:37:29 GMT 2025
PRIMARY
FDA UNII
71KV7F609O
Created by admin on Tue Apr 01 22:37:29 GMT 2025 , Edited by admin on Tue Apr 01 22:37:29 GMT 2025
PRIMARY
NCI_THESAURUS
C175823
Created by admin on Tue Apr 01 22:37:29 GMT 2025 , Edited by admin on Tue Apr 01 22:37:29 GMT 2025
PRIMARY
CAS
2304799-73-1
Created by admin on Tue Apr 01 22:37:29 GMT 2025 , Edited by admin on Tue Apr 01 22:37:29 GMT 2025
PRIMARY
USAN
JK-248
Created by admin on Tue Apr 01 22:37:29 GMT 2025 , Edited by admin on Tue Apr 01 22:37:29 GMT 2025
PRIMARY
From To
2_225 4_215
1_225 3_215
1_22 1_96
2_22 2_96
1_149 1_205
2_149 2_205
1_231 2_231
1_234 2_234
1_266 1_326
2_266 2_326
1_372 1_430
2_372 2_430
3_23 3_89
4_23 4_89
3_135 3_195
4_135 4_195
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_302
N 2_302
Related Record Type Details
Structure of UZOPTIRINE
CONJUGATE COMPONENT->CONJUGATE
MIPASETAMAB
PARENT -> CONJUGATE
Related Record Type Details
MIPASETAMAB UZOPTIRINE
ACTIVE MOIETY
Immunomodulator, antineoplastic

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO_ACID_SUBSTITUTION [1_302] [2_302] SITE_SPECIFIC N ASPARAGINYL SG-3199 LINKER 1 WB9ZA2PX7K
AMINO_ACID_SUBSTITUTION [1_302] [2_302] SITE_SPECIFIC N ASPARAGINYL SG-3199 LINKER 2 5F5WC262W3
AMINO_ACID_SUBSTITUTION [1_1] [2_1] N-TERMINUS PIDOLIC ACID SZB83O1W42
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
NIH
NCATS
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