U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

2017
411
Substance Class Protein
Created
by admin
on Mon Mar 31 18:37:17 GMT 2025
Edited
by admin
on Mon Mar 31 18:37:17 GMT 2025
Protein Type MONOCLONAL ANTIBODY
Protein Sub Type IGG1
Sequence Origin HUMANIZED MOUSE
Sequence Type COMPLETE
Record UNII
71492GE1FX
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
BENRALIZUMAB
INN   USAN   WHO-DD  
USAN   INN  
Official Name English
BIW-8405
Preferred Name English
Benralizumab [WHO-DD]
Common Name English
benralizumab [INN]
Common Name English
MEDI-563
Code English
BENRALIZUMAB [PURPLE BOOK CDER]
Common Name English
BENRALIZUMAB [MI]
Common Name English
IMMUNOGLOBULIN G1-KAPPA, ANTI-(HOMO SAPIENS IL5RA (INTERLEUKIN 5RECEPTOR SUBUNIT ALPHA, CD125)), HUMANIZED MONOCLONAL ANTIBODY
Common Name English
BENRALIZUMAB [JAN]
Common Name English
FASENRA
Brand Name English
BENRALIZUMAB [USAN]
Common Name English
Classification Tree Code System Code
FDA ORPHAN DRUG 828221
Created by admin on Mon Mar 31 18:37:17 GMT 2025 , Edited by admin on Mon Mar 31 18:37:17 GMT 2025
NCI_THESAURUS C20401
Created by admin on Mon Mar 31 18:37:17 GMT 2025 , Edited by admin on Mon Mar 31 18:37:17 GMT 2025
FDA ORPHAN DRUG 660018
Created by admin on Mon Mar 31 18:37:17 GMT 2025 , Edited by admin on Mon Mar 31 18:37:17 GMT 2025
FDA ORPHAN DRUG 670018
Created by admin on Mon Mar 31 18:37:17 GMT 2025 , Edited by admin on Mon Mar 31 18:37:17 GMT 2025
FDA ORPHAN DRUG 670518
Created by admin on Mon Mar 31 18:37:17 GMT 2025 , Edited by admin on Mon Mar 31 18:37:17 GMT 2025
NDF-RT N0000193803
Created by admin on Mon Mar 31 18:37:17 GMT 2025 , Edited by admin on Mon Mar 31 18:37:17 GMT 2025
WHO-ATC R03DX10
Created by admin on Mon Mar 31 18:37:17 GMT 2025 , Edited by admin on Mon Mar 31 18:37:17 GMT 2025
FDA ORPHAN DRUG 838521
Created by admin on Mon Mar 31 18:37:17 GMT 2025 , Edited by admin on Mon Mar 31 18:37:17 GMT 2025
Code System Code Type Description
DRUG CENTRAL
5263
Created by admin on Mon Mar 31 18:37:17 GMT 2025 , Edited by admin on Mon Mar 31 18:37:17 GMT 2025
PRIMARY
NCI_THESAURUS
C88594
Created by admin on Mon Mar 31 18:37:17 GMT 2025 , Edited by admin on Mon Mar 31 18:37:17 GMT 2025
PRIMARY
DAILYMED
71492GE1FX
Created by admin on Mon Mar 31 18:37:17 GMT 2025 , Edited by admin on Mon Mar 31 18:37:17 GMT 2025
PRIMARY
SMS_ID
100000167493
Created by admin on Mon Mar 31 18:37:17 GMT 2025 , Edited by admin on Mon Mar 31 18:37:17 GMT 2025
PRIMARY
RXCUI
1989100
Created by admin on Mon Mar 31 18:37:17 GMT 2025 , Edited by admin on Mon Mar 31 18:37:17 GMT 2025
PRIMARY
DRUG BANK
DB12023
Created by admin on Mon Mar 31 18:37:17 GMT 2025 , Edited by admin on Mon Mar 31 18:37:17 GMT 2025
PRIMARY
MERCK INDEX
m12053
Created by admin on Mon Mar 31 18:37:17 GMT 2025 , Edited by admin on Mon Mar 31 18:37:17 GMT 2025
PRIMARY
LACTMED
Benralizumab
Created by admin on Mon Mar 31 18:37:17 GMT 2025 , Edited by admin on Mon Mar 31 18:37:17 GMT 2025
PRIMARY
USAN
XX-25
Created by admin on Mon Mar 31 18:37:17 GMT 2025 , Edited by admin on Mon Mar 31 18:37:17 GMT 2025
PRIMARY
INN
9233
Created by admin on Mon Mar 31 18:37:17 GMT 2025 , Edited by admin on Mon Mar 31 18:37:17 GMT 2025
PRIMARY
ChEMBL
CHEMBL1742991
Created by admin on Mon Mar 31 18:37:17 GMT 2025 , Edited by admin on Mon Mar 31 18:37:17 GMT 2025
PRIMARY
CAS
1044511-01-4
Created by admin on Mon Mar 31 18:37:17 GMT 2025 , Edited by admin on Mon Mar 31 18:37:17 GMT 2025
PRIMARY
WIKIPEDIA
BENRALIZUMAB
Created by admin on Mon Mar 31 18:37:17 GMT 2025 , Edited by admin on Mon Mar 31 18:37:17 GMT 2025
PRIMARY
EVMPD
SUB181746
Created by admin on Mon Mar 31 18:37:17 GMT 2025 , Edited by admin on Mon Mar 31 18:37:17 GMT 2025
PRIMARY
FDA UNII
71492GE1FX
Created by admin on Mon Mar 31 18:37:17 GMT 2025 , Edited by admin on Mon Mar 31 18:37:17 GMT 2025
PRIMARY
From To
1_22 1_96
1_148 1_204
1_224 3_214
1_230 2_230
1_233 2_233
1_265 1_325
1_371 1_429
2_22 2_96
2_148 2_204
2_224 4_214
2_265 2_325
2_371 2_429
3_23 3_88
3_134 3_194
4_23 4_88
4_134 4_194
Glycosylation Type MAMMALIAN
Glycosylation Link Type Site
N 1_301
N 2_301
Related Record Type Details
INTERLEUKIN-5 RECEPTOR SUBUNIT ALPHA
TARGET -> INHIBITOR
Binds to IL-5R? and rapidly depletes levels of eosinophils and basophils through antibody-dependent cell-mediated cytotoxicity.
LOW AFFINITY IMMUNOGLOBULIN GAMMA FC REGION RECEPTOR III-A
TARGET->LIGAND
Related Record Type Details
BENRALIZUMAB
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
Biological Half-life PHARMACOKINETIC
MOL_WEIGHT:APPROXIMATE CHEMICAL
NIH
NCATS
PRIVACY NOTICE
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966