U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C14H19F3N4O
Molecular Weight 316.3221
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FLUPRAZINE

SMILES

NC(=O)NCCN1CCN(CC1)C2=CC(=CC=C2)C(F)(F)F

InChI

InChIKey=CHQKHXJPWDSTPY-UHFFFAOYSA-N
InChI=1S/C14H19F3N4O/c15-14(16,17)11-2-1-3-12(10-11)21-8-6-20(7-9-21)5-4-19-13(18)22/h1-3,10H,4-9H2,(H3,18,19,22)

HIDE SMILES / InChI

Molecular Formula C14H19F3N4O
Molecular Weight 316.3221
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Fluprazine (previously known as DU27716), a psychoactive drug was studied as a behaviorally selective, anti-aggressive agent. Experiments on rodents have shown that fluprazine didn’t appreciably affect defensive attack or other defensive behaviors even though it strongly inhibited offensive attack. This agent is used to test both differences and similarities in neurochemical substrates and adaptive significance of different forms of intraspecific aggression.

Approval Year

Targets

Primary TargetPharmacologyConditionPotency
510.0 nM [Ki]
1500.0 nM [Ki]
1800.0 nM [Ki]

PubMed

Substance Class Chemical
Record UNII
713BBL6840
Record Status Validated (UNII)
Record Version