U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula S8
Molecular Weight 256.52
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of Sulfur

SMILES

S1SSSSSSS1

InChI

InChIKey=JLQNHALFVCURHW-UHFFFAOYSA-N
InChI=1S/S8/c1-2-4-6-8-7-5-3-1

HIDE SMILES / InChI

Molecular Formula S8
Molecular Weight 256.52
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Mercury(I) iodide is a chemical compound that has been used as a drug in the 19th century, sometimes under the contemporary name of 'protiodide of mercury'. Mercury(I) iodide was used to treat a wide range of conditions; everything from acne to kidney disease and in particular was the treatment of choice for syphilis. It was available over the counter at any drugstore in the world, the most common form being a concoction of protiodide, licorice, glycerin, and marshmallow. Taken orally, and in low doses, protiodide causes excessive salivation, fetid breath, spongy and bleeding gums, and sore teeth. Excessive use or an overdose causes physical weakness, loss of teeth, hemolysing (destruction of the red blood cells) of the blood and necrosis of the bones and tissues of the body. Early signs of an overdose or excessive use are muscular tremors, chorea, and locomotor ataxia. Violent bloody vomiting and voiding also occur.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
SULFUR 8 LIGHT ANTI-DANDRUFF HAIR AND SCALP CONDITIONER

Approved Use

Use: Controls scalp itching and flaking due to dandruff.

Launch Date

1990
PubMed

PubMed

TitleDatePubMed
NEPHROTIC SYNDROME CAUSED BY PROTIODIDE OF MERCURY.
1965 Mar
Convulsions following application of gamma benzene hexachloride.
1981 Jul
Clinical comparison of two radiocolloids for internal mammary lymphoscintigraphy.
1985 Dec
Widespread occurrence of bacterial thiol methyltransferases and the biogenic emission of methylated sulfur gases.
1987 Jul
Activity of polymorphonuclear leukocytes in the presence of sulfide.
1989 Sep
Lung dysfunction in animal confinement workers--chairman's report to the Scientific Committee of the Third International Symposium: issues in health, safety and agriculture, held in Saskatoon, Saskatchewan, Canada, May 10-15, 1992.
1992
The usefulness of thiosulfate as an indicator of hydrogen sulfide poisoning: three cases.
1997
Hydrogen sulfide and colonic epithelial metabolism: implications for ulcerative colitis.
2001 Aug
A salivary incubation test for evaluation of oral malodor: a pilot study.
2003 Jul
Major and trace elements in whole blood of phlebotomized patients with porphyria cutanea tarda.
2005
Distribution and function of the hydrogen sulfide-sensitive TRPA1 ion channel in rat urinary bladder.
2008 Feb
Disulfides as cyanide antidotes: evidence for a new in vivo oxidative pathway for cyanide detoxification.
2009 Dec
Multiple protective activities of neuroglobin in cultured neuronal cells exposed to hypoxia re-oxygenation injury.
2009 Mar
HIF-1 and SKN-1 coordinate the transcriptional response to hydrogen sulfide in Caenorhabditis elegans.
2011
S-Propargyl-cysteine (SPRC) attenuated lipopolysaccharide-induced inflammatory response in H9c2 cells involved in a hydrogen sulfide-dependent mechanism.
2011 Jun
Detoxification of methylmercury by hydrogen sulfide-producing enzyme in Mammalian cells.
2011 Oct 17
Sulfide induces apoptosis and Rho kinase-dependent cell blebbing in Jurkat cells.
2013 Jul
Dexamethasone ameliorates H₂S-induced acute lung injury by alleviating matrix metalloproteinase-2 and -9 expression.
2014
Downregulation of cystathionine β-synthase/hydrogen sulfide contributes to rotenone-induced microglia polarization toward M1 type.
2014 Aug 22
H2S inhibition of chemical hypoxia-induced proliferation of HPASMCs is mediated by the upregulation of COX-2/PGI2.
2014 Feb
Patents
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:58:29 GMT 2023
Edited
by admin
on Fri Dec 15 15:58:29 GMT 2023
Record UNII
70FD1KFU70
Record Status Validated (UNII)
Record Version
  • Download
Related Record Type
Name Type Language
Sulfur
HSDB   INCI   MART.   MI   ORANGE BOOK   VANDF   WHO-DD  
INCI  
Official Name English
SULFUR [ORANGE BOOK]
Common Name English
SULFUR [HSDB]
Common Name English
SULPHUR
HPUS   ISO  
Systematic Name English
ORTHORHOMBIC SULFUR
Common Name English
Sulfur [WHO-DD]
Common Name English
SULFUR,MICRONIZED [VANDF]
Common Name English
SULFUR [MART.]
Common Name English
.ALPHA.-SULFUR
Common Name English
SULPHUR [ISO]
Common Name English
NSC-403664
Code English
SULFUR [INCI]
Common Name English
SULFUR [MI]
Common Name English
SULPHUR [HPUS]
Common Name English
SULFUR (S8)
Common Name English
SULFUR [EP MONOGRAPH]
Common Name English
SULFUR, PHARMACEUTICAL [MI]
Common Name English
SULFUR [JAN]
Common Name English
LIU HUANG
Common Name English
NSC-603623
Code English
SULFUR [VANDF]
Common Name English
Classification Tree Code System Code
WHO-VATC QD10AB02
Created by admin on Fri Dec 15 15:58:29 GMT 2023 , Edited by admin on Fri Dec 15 15:58:29 GMT 2023
CFR 21 CFR 310.531
Created by admin on Fri Dec 15 15:58:29 GMT 2023 , Edited by admin on Fri Dec 15 15:58:29 GMT 2023
CFR 21 CFR 333.320
Created by admin on Fri Dec 15 15:58:29 GMT 2023 , Edited by admin on Fri Dec 15 15:58:29 GMT 2023
LOINC 87449-5
Created by admin on Fri Dec 15 15:58:29 GMT 2023 , Edited by admin on Fri Dec 15 15:58:29 GMT 2023
CFR 21 CFR 358.710
Created by admin on Fri Dec 15 15:58:29 GMT 2023 , Edited by admin on Fri Dec 15 15:58:29 GMT 2023
EPA PESTICIDE CODE 77501
Created by admin on Fri Dec 15 15:58:29 GMT 2023 , Edited by admin on Fri Dec 15 15:58:29 GMT 2023
LOINC 87450-3
Created by admin on Fri Dec 15 15:58:29 GMT 2023 , Edited by admin on Fri Dec 15 15:58:29 GMT 2023
WHO-ATC D10AB02
Created by admin on Fri Dec 15 15:58:29 GMT 2023 , Edited by admin on Fri Dec 15 15:58:29 GMT 2023
DSLD 1352 (Number of products:160)
Created by admin on Fri Dec 15 15:58:29 GMT 2023 , Edited by admin on Fri Dec 15 15:58:29 GMT 2023
CFR 21 CFR 333.310
Created by admin on Fri Dec 15 15:58:29 GMT 2023 , Edited by admin on Fri Dec 15 15:58:29 GMT 2023
CFR 21 CFR 358.720
Created by admin on Fri Dec 15 15:58:29 GMT 2023 , Edited by admin on Fri Dec 15 15:58:29 GMT 2023
Code System Code Type Description
FDA UNII
70FD1KFU70
Created by admin on Fri Dec 15 15:58:29 GMT 2023 , Edited by admin on Fri Dec 15 15:58:29 GMT 2023
PRIMARY
ECHA (EC/EINECS)
231-722-6
Created by admin on Fri Dec 15 15:58:29 GMT 2023 , Edited by admin on Fri Dec 15 15:58:29 GMT 2023
PRIMARY
EVMPD
SUB124719
Created by admin on Fri Dec 15 15:58:29 GMT 2023 , Edited by admin on Fri Dec 15 15:58:29 GMT 2023
ALTERNATIVE
EPA CompTox
DTXSID80872924
Created by admin on Fri Dec 15 15:58:29 GMT 2023 , Edited by admin on Fri Dec 15 15:58:29 GMT 2023
PRIMARY
CAS
7704-34-9
Created by admin on Fri Dec 15 15:58:29 GMT 2023 , Edited by admin on Fri Dec 15 15:58:29 GMT 2023
ALTERNATIVE
PUBCHEM
66348
Created by admin on Fri Dec 15 15:58:29 GMT 2023 , Edited by admin on Fri Dec 15 15:58:29 GMT 2023
PRIMARY
SMS_ID
100000090444
Created by admin on Fri Dec 15 15:58:29 GMT 2023 , Edited by admin on Fri Dec 15 15:58:29 GMT 2023
PRIMARY
NCI_THESAURUS
C68289
Created by admin on Fri Dec 15 15:58:29 GMT 2023 , Edited by admin on Fri Dec 15 15:58:29 GMT 2023
PRIMARY
NSC
403664
Created by admin on Fri Dec 15 15:58:29 GMT 2023 , Edited by admin on Fri Dec 15 15:58:29 GMT 2023
PRIMARY
ALANWOOD
sulfur
Created by admin on Fri Dec 15 15:58:29 GMT 2023 , Edited by admin on Fri Dec 15 15:58:29 GMT 2023
PRIMARY
MERCK INDEX
m10377
Created by admin on Fri Dec 15 15:58:29 GMT 2023 , Edited by admin on Fri Dec 15 15:58:29 GMT 2023
PRIMARY Merck Index
WIKIPEDIA
Sulfur (pharmacy)
Created by admin on Fri Dec 15 15:58:29 GMT 2023 , Edited by admin on Fri Dec 15 15:58:29 GMT 2023
PRIMARY
DAILYMED
70FD1KFU70
Created by admin on Fri Dec 15 15:58:29 GMT 2023 , Edited by admin on Fri Dec 15 15:58:29 GMT 2023
PRIMARY
CHEBI
17909
Created by admin on Fri Dec 15 15:58:29 GMT 2023 , Edited by admin on Fri Dec 15 15:58:29 GMT 2023
PRIMARY
CHEBI
26833
Created by admin on Fri Dec 15 15:58:29 GMT 2023 , Edited by admin on Fri Dec 15 15:58:29 GMT 2023
PRIMARY
WIKIPEDIA
SULFUR
Created by admin on Fri Dec 15 15:58:29 GMT 2023 , Edited by admin on Fri Dec 15 15:58:29 GMT 2023
PRIMARY
DRUG CENTRAL
4260
Created by admin on Fri Dec 15 15:58:29 GMT 2023 , Edited by admin on Fri Dec 15 15:58:29 GMT 2023
PRIMARY
EVMPD
SUB15433MIG
Created by admin on Fri Dec 15 15:58:29 GMT 2023 , Edited by admin on Fri Dec 15 15:58:29 GMT 2023
PRIMARY
RXCUI
10223
Created by admin on Fri Dec 15 15:58:29 GMT 2023 , Edited by admin on Fri Dec 15 15:58:29 GMT 2023
PRIMARY
MERCK INDEX
m10369
Created by admin on Fri Dec 15 15:58:29 GMT 2023 , Edited by admin on Fri Dec 15 15:58:29 GMT 2023
PRIMARY Merck Index
ChEMBL
CHEMBL2105487
Created by admin on Fri Dec 15 15:58:29 GMT 2023 , Edited by admin on Fri Dec 15 15:58:29 GMT 2023
PRIMARY
MESH
D013455
Created by admin on Fri Dec 15 15:58:29 GMT 2023 , Edited by admin on Fri Dec 15 15:58:29 GMT 2023
PRIMARY
LACTMED
Sulfur
Created by admin on Fri Dec 15 15:58:29 GMT 2023 , Edited by admin on Fri Dec 15 15:58:29 GMT 2023
PRIMARY
CAS
10544-50-0
Created by admin on Fri Dec 15 15:58:29 GMT 2023 , Edited by admin on Fri Dec 15 15:58:29 GMT 2023
PRIMARY
NSC
603623
Created by admin on Fri Dec 15 15:58:29 GMT 2023 , Edited by admin on Fri Dec 15 15:58:29 GMT 2023
PRIMARY
Related Record Type Details
SUB_CONCEPT->SUBSTANCE
SUB_CONCEPT->SUBSTANCE
SUB_CONCEPT->SUBSTANCE
Related Record Type Details
ACTIVE MOIETY