Stereochemistry | ACHIRAL |
Molecular Formula | C7H6O4 |
Molecular Weight | 154.1201 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)C1=C(O)C(O)=CC=C1
InChI
InChIKey=GLDQAMYCGOIJDV-UHFFFAOYSA-N
InChI=1S/C7H6O4/c8-5-3-1-2-4(6(5)9)7(10)11/h1-3,8-9H,(H,10,11)
Molecular Formula | C7H6O4 |
Molecular Weight | 154.1201 |
Charge | 0 |
Count |
MOL RATIO
1 MOL RATIO (average) |
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
2,3-Dihydroxybenzoic acid is a natural phenol found in Phyllanthus acidus and in the aquatic fern Salvinia molesta. Hydroxyl radical attack upon salicylate leads to the generation of 2,3-dihydroxybenzoic acid (2,3-DHBA) and therefore can be used to assess hydroxyl radical formation both in vitro and in vivo. 2,3-Dihydroxybenzoic acid is a biological marker for the detection and quantification of hydroxyl radicals. 2,3-dihydroxybenzoic acid (DHB) has been safely administered to humans as an iron-chelating agent.
Approval Year
PubMed
Patents
Sample Use Guides
Rats were injected intravenously with doses of 2,3-Dihydroxybenzoic acid (DHB) including 1, 10,50, 100, and 150 mg/kg (pH 7.40; 300 to 380 mOsm/L) as well as 300 mg/kg (pH 7.40; 500 mOsm/L). The intravenous infusion of DHB 10
min before CVF administration reduced lung injury as measured by permeability
index in a dose-dependent manner. The DHB at doses of 10, 50,100,
150, and 300 mg/kg was associated with a 33, 45, 48, 63, and 78% reduction in
lung injury, respectively.
Route of Administration:
Intravenous