Firsekibart

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 10:11:06 GMT 2025` Edited by `admin` on `Wed Apr 02 10:11:06 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG4
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	6ZU8B6H4KT
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Firsekibart

Official Name

English

H-gamma4 heavy chain Homo sapiens (1-455) [VH (Homo sapiens IGHV3-49*05 (94.0%) -(IGHD) -IGHJ6*01 (94.4%), CDRIMGT [8.10.19] (26-33.51-60.99-117)) (1-128) -Homo sapiens IGHG4*01, nG4m(a) CH2 L92, 12-G4v5 h P10(CH1 (129-226), hinge 1-12 S10>P (236) (227-2

Preferred Name

English

Immunoglobulin G4 [236-proline], anti-(human interleukin 1?) (human monoclonal GenSci048 ?4-chain), disulfide with human monoclonal GenSci048 ?-chain, dimer

Common Name

English

immunoglobulin G4-lambda2, anti-[Homo sapiens IL1B (interleukin 1 beta, IL-1B, 1L1F2)], Homo sapiens monoclonal antibody

Common Name

English

firsekibart [INN]

Common Name

English

Code System Code Type Description

CAS

2981430-39-9

Created by admin on Wed Apr 02 10:11:06 GMT 2025 , Edited by admin on Wed Apr 02 10:11:06 GMT 2025

PRIMARY

INN

13353

Created by admin on Wed Apr 02 10:11:06 GMT 2025 , Edited by admin on Wed Apr 02 10:11:06 GMT 2025

PRIMARY

FDA UNII

6ZU8B6H4KT

Created by admin on Wed Apr 02 10:11:06 GMT 2025 , Edited by admin on Wed Apr 02 10:11:06 GMT 2025

PRIMARY

From	To
4_134	4_193
4_22	4_87
3_134	3_193
3_22	3_87
2_375	2_433
2_269	2_329
2_155	2_211
2_142	4_211
2_105	2_112
2_22	2_98
1_375	1_433
1_269	1_329
1_237	2_237
1_234	2_234
1_155	1_211
1_142	3_211
1_105	1_112
1_22	1_98

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_305
N	2_305

Related Record Type Details


					X62226112J

INTERLEUKIN-1 .BETA. HUMAN

TARGET -> INHIBITOR

Amount:

Related Record Type Details


					6ZU8B6H4KT

Firsekibart

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_455] [2_455]	C-TERMINUS	K		LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL