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Details

Stereochemistry ACHIRAL
Molecular Formula CH2O.H2O
Molecular Weight 48.0413
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of METHYLENE GLYCOL

SMILES

C=O.O

InChI

InChIKey=MGJURKDLIJVDEO-UHFFFAOYSA-N
InChI=1S/CH2O.H2O/c1-2;/h1H2;1H2

HIDE SMILES / InChI

Molecular Formula CH2O
Molecular Weight 30.026
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula H2O
Molecular Weight 18.0153
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment:: https://www.drugs.com/pro/formaldehyde-liquid.html

Formaldehyde is a naturally occurring organic compound, and an important industrial precursor to many other materials and organic compounds. Formaldehyde solution (formalin) is used as a disinfectant. Formaldehyde vapors are toxic, upon entry formaldehyde reacts readily with macromolecules, including DNA to form DNA-protein and DNA-DNA cross-links.

Originator

Curator's Comment:: Formaldehyde was first reported in 1859 by the Russian chemist Aleksandr Butlerov

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: CHEMBL2311221
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
FORMALDEHYDE 10%

Approved Use

Drying agent for pre and post surgical removal of warts, or for non-surgical laser treatment of warts where dryness is required. Safeguards against offensive odor and dries excessive moisture of feet. Not to be used in patients known to be sensitive to any of the ingredients in this product.
PubMed

PubMed

TitleDatePubMed
Intravesical formalin for the control of intractable bladder hemorrhage secondary to cystitis or cancer.
1975 Oct
A pathology-MRI study of the short-T2 component in formalin-fixed multiple sclerosis brain.
2000 Nov 28
Antinociceptive properties of extracts of new species of plants of the genus Phyllanthus (Euphorbiaceae).
2000 Sep
Occupational asthma due to formaldehyde.
2001 Aug
Effect of sludge-amendment or nutrient addition on the biodegradation of the herbicide isoproturon in soil.
2001 Aug
B vitamins induce an antinociceptive effect in the acetic acid and formaldehyde models of nociception in mice.
2001 Jun 15
Endodontic treatment of permanent teeth in children with a new calcium-carbamide-formaldehyde paste.
2002
Sensitizing capacity of two monomeric aldehyde components in p-tert-butylphenol-formaldehyde resin.
2002
Formaldehyde enhances mite allergen-induced eosinophilic inflammation in the murine airway.
2002
Domestic exposure to formaldehyde significantly increases the risk of asthma in young children.
2002 Aug
Gene-gun particle with pro-opiomelanocortin cDNA produces analgesia against formalin-induced pain in rats.
2002 Aug
Results of long-term experimental studies on the carcinogenicity of formaldehyde and acetaldehyde in rats.
2002 Dec
A glutathione-dependent formaldehyde-activating enzyme (Gfa) from Paracoccus denitrificans detected and purified via two-dimensional proton exchange NMR spectroscopy.
2002 Feb 1
Antiprotozoals effective in vitro against the scuticociliate fish pathogen Philasterides dicentrarchi.
2002 Jun 3
Elevated Skp2 protein expression in human prostate cancer: association with loss of the cyclin-dependent kinase inhibitor p27 and PTEN and with reduced recurrence-free survival.
2002 Nov
A role for peripheral somatostatin receptors in counter-irritation-induced analgesia.
2003
Profound, non-opioid analgesia produced by the high-efficacy 5-HT(1A) agonist F 13640 in the formalin model of tonic nociceptive pain.
2003 Apr
Glutaraldehyde-induced and formaldehyde-induced allergic contact dermatitis among dental hygienists and assistants.
2003 Aug
Structure-function relationships in human Class III alcohol dehydrogenase (formaldehyde dehydrogenase).
2003 Feb 1
Formaldehyde application for haemorrhagic radiation-induced proctitis: a clinical and histological study.
2003 Jan
[Formaldehyde exposure levels and exposure control measures during an anatomy dissecting course].
2003 Jun
Inhibition of cyclic guanosine 5'-monophosphate-dependent protein kinase I (PKG-I) in lumbar spinal cord reduces formalin-induced hyperalgesia and PKG upregulation.
2003 Mar
Formaldehyde-induced gene expression in F344 rat nasal respiratory epithelium.
2003 May 1
[Effects of formaldehyde on germ cells of male mice].
2003 Nov
Extended follow-up of a cohort of british chemical workers exposed to formaldehyde.
2003 Nov 5
Biologically motivated computational modeling of formaldehyde carcinogenicity in the F344 rat.
2003 Oct
Combined effects of tumor promoters and serum on proliferin mRNA induction: a biomarker sensitive to saccharin, 2,3,7,8-TCDD, and other compounds at minimal concentrations promoting C3H/10T1/2 cell transformation.
2003 Oct 24
Pathological effects of formalin (37% formaldehyde) mixed in feed or administered into the crops of White Leghorn cockerels.
2003 Sep
Antinociceptive profile of (-)-spectaline: a piperidine alkaloid from Cassia leptophylla.
2003 Sep
Inhalation of low-level formaldehyde enhances nerve growth factor production in the hippocampus of mice.
2004
A novel gamma-N-methylaminobutyrate demethylating oxidase involved in catabolism of the tobacco alkaloid nicotine by Arthrobacter nicotinovorans pAO1.
2004 Dec
GABAA receptor partially mediated propofol-induced hyperalgesia at superspinal level and analgesia at spinal cord level in rats.
2004 Dec
Protein associated with Myc (PAM) is involved in spinal nociceptive processing.
2004 Feb
Allergic contact sensitivity in elderly patients.
2004 Jun
Hepatocyte proliferation in chronic hepatitis C: correlation with degree of liver disease and serum alpha-fetoprotein.
2004 Jun
Biodegradation of alachlor by soil streptomycetes.
2004 Jun
Mortality from solid cancers among workers in formaldehyde industries.
2004 Jun 15
[Allergy to formaldehyde].
2004 Sep
Use of the platelet reactivity index by Grotemeyer, platelet function analyzer, and retention test Homburg to monitor therapy with antiplatelet drugs.
2005
Antinociceptive properties of mixture of alpha-amyrin and beta-amyrin triterpenes: evidence for participation of protein kinase C and protein kinase A pathways.
2005 Apr
Methanol, formaldehyde, and sodium formate exposure in rat and mouse conceptuses: a potential role of the visceral yolk sac in embryotoxicity.
2005 Feb
The role of intracellularly released formaldehyde and butyric acid in the anticancer activity of acyloxyalkyl esters.
2005 Feb 24
An ecological study of the association of environmental chemicals on breast cancer incidence in Texas.
2005 Jul
Contact sensitivity to preservatives in Turkey.
2005 Jun
Redox imbalance induced by contact sensitizers triggers the maturation of dendritic cells.
2005 Mar
[Study on differential display genes of tolerant-damage of MRC-5 induced by formaldehyde of low dose].
2005 May
The interaction of trimethylamine dehydrogenase and electron-transferring flavoprotein.
2005 May 27
Thrombotic thrombocytopenic purpura causing rapid unexpected death: value of CD61 immunohistochemical staining in diagnosis.
2005 May-Jun
Detection of chlamydial bodies and antigens in the central nervous system of patients with multiple sclerosis.
2005 Oct 1
Protective effects of omega-3 essential fatty acids against formaldehyde-induced neuronal damage in prefrontal cortex of rats.
2006 May-Jun
Patents

Sample Use Guides

Formaldehyde 10% solution is applied topically once a day to affected areas.
Route of Administration: Topical
In Vitro Use Guide
Human lymphoblasts were exposed in vitro to various concentrations of formaldehyde (HCHO) in single and multiple treatment regimens to determine relative mutagenic efficiency. HCHO treatment resulted in a significant nonlinear increase in DNA-protein crosslinks at concentrations greater than 50 uM X 2 h, which correlated with the onset of significant toxicity in this cell line.
Substance Class Chemical
Created
by admin
on Fri Jun 25 20:36:07 UTC 2021
Edited
by admin
on Fri Jun 25 20:36:07 UTC 2021
Record UNII
6Z20YM9257
Record Status Validated (UNII)
Record Version
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Name Type Language
METHYLENE GLYCOL
INCI  
INCI  
Official Name English
METHANEDIOL
Systematic Name English
FORMALDEHYDE, MONOHYDRATE
Systematic Name English
HYDRATED FORMALDEHYDE
Common Name English
DIHYDROXYMETHANE
Systematic Name English
METHYLENEDIOL
Common Name English
1,1-DIHYDROXYMETHANE
Systematic Name English
METHYLENE GLYCOL [INCI]
Common Name English
Code System Code Type Description
ECHA (EC/EINECS)
207-339-5
Created by admin on Fri Jun 25 20:36:07 UTC 2021 , Edited by admin on Fri Jun 25 20:36:07 UTC 2021
PRIMARY
CAS
463-57-0
Created by admin on Fri Jun 25 20:36:07 UTC 2021 , Edited by admin on Fri Jun 25 20:36:07 UTC 2021
GENERIC (FAMILY)
EPA CompTox
463-57-0
Created by admin on Fri Jun 25 20:36:07 UTC 2021 , Edited by admin on Fri Jun 25 20:36:07 UTC 2021
PRIMARY
FDA UNII
6Z20YM9257
Created by admin on Fri Jun 25 20:36:07 UTC 2021 , Edited by admin on Fri Jun 25 20:36:07 UTC 2021
PRIMARY
RXCUI
1797646
Created by admin on Fri Jun 25 20:36:07 UTC 2021 , Edited by admin on Fri Jun 25 20:36:07 UTC 2021
PRIMARY
PUBCHEM
22136924
Created by admin on Fri Jun 25 20:36:07 UTC 2021 , Edited by admin on Fri Jun 25 20:36:07 UTC 2021
PRIMARY
WIKIPEDIA
METHANEDIOL
Created by admin on Fri Jun 25 20:36:07 UTC 2021 , Edited by admin on Fri Jun 25 20:36:07 UTC 2021
PRIMARY