Details
Stereochemistry | ACHIRAL |
Molecular Formula | CH2O.H2O |
Molecular Weight | 48.0413 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
O.C=O
InChI
InChIKey=MGJURKDLIJVDEO-UHFFFAOYSA-N
InChI=1S/CH2O.H2O/c1-2;/h1H2;1H2
Molecular Formula | H2O |
Molecular Weight | 18.0153 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | CH2O |
Molecular Weight | 30.026 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
DescriptionSources: https://www.drugbank.ca/drugs/DB03843Curator's Comment: description was created based on several sources, including
https://www.nap.edu/read/13142/chapter/6 |
https://www.drugs.com/pro/formaldehyde-liquid.html
Sources: https://www.drugbank.ca/drugs/DB03843
Curator's Comment: description was created based on several sources, including
https://www.nap.edu/read/13142/chapter/6 |
https://www.drugs.com/pro/formaldehyde-liquid.html
Formaldehyde is a naturally occurring organic compound, and an important industrial precursor to many other materials and organic compounds. Formaldehyde solution (formalin) is used as a disinfectant. Formaldehyde vapors are toxic, upon entry formaldehyde reacts readily with macromolecules, including DNA to form DNA-protein and DNA-DNA cross-links.
CNS Activity
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL2311221 Sources: https://www.ncbi.nlm.nih.gov/pubmed/3796657 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Curative | FORMALDEHYDE 10% Approved UseDrying agent for pre and post surgical removal of warts, or for non-surgical laser treatment of warts where dryness is required. Safeguards against offensive odor and dries excessive moisture of feet. Not to be used in patients known to be sensitive to any of the ingredients in this product. |
PubMed
Title | Date | PubMed |
---|---|---|
The involvement of K+ channels and Gi/o protein in the antinociceptive action of the gallic acid ethyl ester. | 1999 Aug 20 |
|
Evidence for the involvement of spinal endogenous ATP and P2X receptors in nociceptive responses caused by formalin and capsaicin in mice. | 1999 Dec |
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Oral antinociception and oedema inhibition produced by NPC 18884, a non-peptidic bradykinin B2 receptor antagonist. | 1999 Sep |
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Characterization of metabolites during biodegradation of hexahydro-1, 3,5-trinitro-1,3,5-triazine (RDX) with municipal anaerobic sludge. | 2000 Jun |
|
A pathology-MRI study of the short-T2 component in formalin-fixed multiple sclerosis brain. | 2000 Nov 28 |
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Eye irritation caused by formaldehyde as an indoor air pollution--a controlled human exposure experiment. | 2001 Sep |
|
Effect of formaldehyde on the expression of adhesion molecules in nasal microvascular endothelial cells: the role of formaldehyde in the pathogenesis of sick building syndrome. | 2002 Feb |
|
Effects of aldehyde dehydrogenase-2 genetic polymorphisms on metabolism of structurally different aldehydes in human liver. | 2002 Jan |
|
Expression of cytokine mRNAs in mice cutaneously exposed to formaldehyde. | 2002 Oct 21 |
|
Glutaraldehyde-induced and formaldehyde-induced allergic contact dermatitis among dental hygienists and assistants. | 2003 Aug |
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The L-arginine/nitric oxide/cyclic-GMP pathway apparently mediates the peripheral antihyperalgesic action of fentanyl in rats. | 2003 Dec |
|
Reproducibility of patch tests: comparison of identical test allergens from different commercial sources. | 2004 Jan |
|
Hepatocyte proliferation in chronic hepatitis C: correlation with degree of liver disease and serum alpha-fetoprotein. | 2004 Jun |
|
Biodegradation of alachlor by soil streptomycetes. | 2004 Jun |
|
Mortality from solid cancers among workers in formaldehyde industries. | 2004 Jun 15 |
|
[Contact sensitization to pharmaceutic aids in dermatologic cosmetic and external use preparations]. | 2004 May |
|
Long-term exposure to low levels of formaldehyde increases the number of tyrosine hydroxylase-immunopositive periglomerular cells in mouse main olfactory bulb. | 2004 May 8 |
|
Protein cross-linkage induced by formaldehyde derived from semicarbazide-sensitive amine oxidase-mediated deamination of methylamine. | 2004 Sep |
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Antinociceptive properties of mixture of alpha-amyrin and beta-amyrin triterpenes: evidence for participation of protein kinase C and protein kinase A pathways. | 2005 Apr |
|
[Study on differential display genes of tolerant-damage of MRC-5 induced by formaldehyde of low dose]. | 2005 May |
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Vitamin E against oxidative damage caused by formaldehyde in frontal cortex and hippocampus: biochemical and histological studies. | 2005 May |
|
Detection of chlamydial bodies and antigens in the central nervous system of patients with multiple sclerosis. | 2005 Oct 1 |
|
Protective effects of omega-3 essential fatty acids against formaldehyde-induced neuronal damage in prefrontal cortex of rats. | 2006 May-Jun |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.drugs.com/pro/formaldehyde-liquid.html
Formaldehyde 10% solution is applied topically once a day to affected areas.
Route of Administration:
Topical
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3796657
Human lymphoblasts were exposed in vitro to various concentrations of formaldehyde (HCHO) in single and multiple treatment regimens to determine relative mutagenic efficiency. HCHO treatment resulted in a significant nonlinear increase in DNA-protein crosslinks at concentrations greater than 50 uM X 2 h, which correlated with the onset of significant toxicity in this cell line.
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:41:55 UTC 2023
by
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Fri Dec 15 15:41:55 UTC 2023
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Record UNII |
6Z20YM9257
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Record Status |
Validated (UNII)
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