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Details

Stereochemistry ACHIRAL
Molecular Formula CH2O.H2O
Molecular Weight 48.0413
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of METHYLENE GLYCOL

SMILES

O.C=O

InChI

InChIKey=MGJURKDLIJVDEO-UHFFFAOYSA-N
InChI=1S/CH2O.H2O/c1-2;/h1H2;1H2

HIDE SMILES / InChI

Molecular Formula H2O
Molecular Weight 18.0153
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula CH2O
Molecular Weight 30.026
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including https://www.nap.edu/read/13142/chapter/6 | https://www.drugs.com/pro/formaldehyde-liquid.html

Formaldehyde is a naturally occurring organic compound, and an important industrial precursor to many other materials and organic compounds. Formaldehyde solution (formalin) is used as a disinfectant. Formaldehyde vapors are toxic, upon entry formaldehyde reacts readily with macromolecules, including DNA to form DNA-protein and DNA-DNA cross-links.

Originator

Curator's Comment: Formaldehyde was first reported in 1859 by the Russian chemist Aleksandr Butlerov

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: CHEMBL2311221
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
FORMALDEHYDE 10%

Approved Use

Drying agent for pre and post surgical removal of warts, or for non-surgical laser treatment of warts where dryness is required. Safeguards against offensive odor and dries excessive moisture of feet. Not to be used in patients known to be sensitive to any of the ingredients in this product.
PubMed

PubMed

TitleDatePubMed
The involvement of K+ channels and Gi/o protein in the antinociceptive action of the gallic acid ethyl ester.
1999 Aug 20
Evidence for the involvement of spinal endogenous ATP and P2X receptors in nociceptive responses caused by formalin and capsaicin in mice.
1999 Dec
Oral antinociception and oedema inhibition produced by NPC 18884, a non-peptidic bradykinin B2 receptor antagonist.
1999 Sep
Characterization of metabolites during biodegradation of hexahydro-1, 3,5-trinitro-1,3,5-triazine (RDX) with municipal anaerobic sludge.
2000 Jun
A pathology-MRI study of the short-T2 component in formalin-fixed multiple sclerosis brain.
2000 Nov 28
Eye irritation caused by formaldehyde as an indoor air pollution--a controlled human exposure experiment.
2001 Sep
Effect of formaldehyde on the expression of adhesion molecules in nasal microvascular endothelial cells: the role of formaldehyde in the pathogenesis of sick building syndrome.
2002 Feb
Effects of aldehyde dehydrogenase-2 genetic polymorphisms on metabolism of structurally different aldehydes in human liver.
2002 Jan
Expression of cytokine mRNAs in mice cutaneously exposed to formaldehyde.
2002 Oct 21
Glutaraldehyde-induced and formaldehyde-induced allergic contact dermatitis among dental hygienists and assistants.
2003 Aug
The L-arginine/nitric oxide/cyclic-GMP pathway apparently mediates the peripheral antihyperalgesic action of fentanyl in rats.
2003 Dec
Reproducibility of patch tests: comparison of identical test allergens from different commercial sources.
2004 Jan
Hepatocyte proliferation in chronic hepatitis C: correlation with degree of liver disease and serum alpha-fetoprotein.
2004 Jun
Biodegradation of alachlor by soil streptomycetes.
2004 Jun
Mortality from solid cancers among workers in formaldehyde industries.
2004 Jun 15
[Contact sensitization to pharmaceutic aids in dermatologic cosmetic and external use preparations].
2004 May
Long-term exposure to low levels of formaldehyde increases the number of tyrosine hydroxylase-immunopositive periglomerular cells in mouse main olfactory bulb.
2004 May 8
Protein cross-linkage induced by formaldehyde derived from semicarbazide-sensitive amine oxidase-mediated deamination of methylamine.
2004 Sep
Antinociceptive properties of mixture of alpha-amyrin and beta-amyrin triterpenes: evidence for participation of protein kinase C and protein kinase A pathways.
2005 Apr
[Study on differential display genes of tolerant-damage of MRC-5 induced by formaldehyde of low dose].
2005 May
Vitamin E against oxidative damage caused by formaldehyde in frontal cortex and hippocampus: biochemical and histological studies.
2005 May
Detection of chlamydial bodies and antigens in the central nervous system of patients with multiple sclerosis.
2005 Oct 1
Protective effects of omega-3 essential fatty acids against formaldehyde-induced neuronal damage in prefrontal cortex of rats.
2006 May-Jun
Patents

Sample Use Guides

Formaldehyde 10% solution is applied topically once a day to affected areas.
Route of Administration: Topical
In Vitro Use Guide
Human lymphoblasts were exposed in vitro to various concentrations of formaldehyde (HCHO) in single and multiple treatment regimens to determine relative mutagenic efficiency. HCHO treatment resulted in a significant nonlinear increase in DNA-protein crosslinks at concentrations greater than 50 uM X 2 h, which correlated with the onset of significant toxicity in this cell line.
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:41:55 UTC 2023
Edited
by admin
on Fri Dec 15 15:41:55 UTC 2023
Record UNII
6Z20YM9257
Record Status Validated (UNII)
Record Version
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Name Type Language
METHYLENE GLYCOL
INCI  
INCI  
Official Name English
METHANEDIOL
Systematic Name English
FORMALDEHYDE, MONOHYDRATE
Systematic Name English
HYDRATED FORMALDEHYDE
Common Name English
DIHYDROXYMETHANE
Systematic Name English
METHYLENEDIOL
Common Name English
1,1-DIHYDROXYMETHANE
Systematic Name English
METHYLENE GLYCOL [INCI]
Common Name English
Code System Code Type Description
ECHA (EC/EINECS)
207-339-5
Created by admin on Fri Dec 15 15:41:55 UTC 2023 , Edited by admin on Fri Dec 15 15:41:55 UTC 2023
PRIMARY
CAS
463-57-0
Created by admin on Fri Dec 15 15:41:55 UTC 2023 , Edited by admin on Fri Dec 15 15:41:55 UTC 2023
GENERIC (FAMILY)
DAILYMED
6Z20YM9257
Created by admin on Fri Dec 15 15:41:55 UTC 2023 , Edited by admin on Fri Dec 15 15:41:55 UTC 2023
PRIMARY
FDA UNII
6Z20YM9257
Created by admin on Fri Dec 15 15:41:55 UTC 2023 , Edited by admin on Fri Dec 15 15:41:55 UTC 2023
PRIMARY
CHEBI
48397
Created by admin on Fri Dec 15 15:41:55 UTC 2023 , Edited by admin on Fri Dec 15 15:41:55 UTC 2023
PRIMARY
RXCUI
1797646
Created by admin on Fri Dec 15 15:41:55 UTC 2023 , Edited by admin on Fri Dec 15 15:41:55 UTC 2023
PRIMARY
PUBCHEM
22136924
Created by admin on Fri Dec 15 15:41:55 UTC 2023 , Edited by admin on Fri Dec 15 15:41:55 UTC 2023
PRIMARY
WIKIPEDIA
METHANEDIOL
Created by admin on Fri Dec 15 15:41:55 UTC 2023 , Edited by admin on Fri Dec 15 15:41:55 UTC 2023
PRIMARY