SODIUM DIMETHYL PHOSPHATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C2H6O4P.Na
Molecular Weight	148.0302
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].COP([O-])(=O)OC

InChI

InChIKey=LMGRDVWNCARTPS-UHFFFAOYSA-M

InChI=1S/C2H7O4P.Na/c1-5-7(3,4)6-2;/h1-2H3,(H,3,4);/q;+1/p-1

HIDE SMILES / InChI

Molecular Formula	C2H6O4P
Molecular Weight	125.0404
Charge	-1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	Na
Molecular Weight	22.98976928
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/12952468 | DOI: 10.1002/anie.199700981 | http://www.google.si/patents/US5250665https://www.ncbi.nlm.nih.gov/pubmed/12657741 | https://www.ncbi.nlm.nih.gov/pubmed/28554999 | https://www.ncbi.nlm.nih.gov/pubmed/27956069 |https://www.ncbi.nlm.nih.gov/pubmed/27690066

Dimethyl phosphate is a metabolite of organophosphate pesticides. The urinary levels of dimethyl phosphate are used as a biochemical marker to assess/predict the health risk of people exposed to pesticides.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Pesticide toxicity 2 Sources: https://www.ncbi.nlm.nih.gov/pubmed/28554999 https://www.ncbi.nlm.nih.gov/pubmed/27956069 https://www.ncbi.nlm.nih.gov/pubmed/12657741	Diagnostic		Not Provided 511	Unknown Approved Use Unknown
Unknown 2596

PubMed

Title	Date	PubMed
Organophosphate pesticide exposure and attention in young Mexican-American children: the CHAMACOS study.	2010-12	21126939
The osmolyte TMAO stabilizes native RNA tertiary structures in the absence of Mg2+: evidence for a large barrier to folding from phosphate dehydration.	2010-11-19	20875423
Quantification of dialkylphosphate metabolites of organophosphorus insecticides in human urine using 96-well plate sample preparation and high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry.	2010-10-01	20494630
Thionate versus Oxon: comparison of stability, uptake, and cell toxicity of ((14)CH(3)O)(2)-labeled methyl parathion and methyl paraoxon with SH-SY5Y cells.	2010-07-28	20590114
Neurobehavioral deficits and increased blood pressure in school-age children prenatally exposed to pesticides.	2010-06	20185383
Determination of dialkyl phosphates in human hair for the biomonitoring of exposure to organophosphate pesticides.	2010-05-15	20226747
Revised method for routine determination of urinary dialkyl phosphates using gas chromatography-mass spectrometry.	2010-05-15	20207202
Sonophotocatalytic degradation of monocrotophos using TiO2 and Fe3+.	2010-05-15	20096998
Association between organophosphate pesticides exposure and thyroid hormones in floriculture workers.	2010-02-15	19914268
Reaction pathway and free-energy barrier for reactivation of dimethylphosphoryl-inhibited human acetylcholinesterase.	2009-12-17	19924840
DNA damage in horticultural farmers: a pilot study showing an association with organophosphate pesticide exposure.	2009-11	19863182
Assessment of long-term subacute exposure to dimethoate by hair analysis of dialkyl phosphates DMP and DMTP in exposed rabbits: The effects of dose, dose duration and hair colour.	2009-10	19674743
Geometrical and vibrational features of phosphate, phosphorothioate and phosphorodithioate linkages interacting with hydrated cations: a DFT study.	2009-09-01	19442575
Combined suicide by oxydemeton-methyl (Metasystox) ingestion and hanging.	2009-08-10	19428202
Ionic liquids as superior solvents for headspace gas chromatography of residual solvents with very low vapor pressure, relevant for pharmaceutical final dosage forms.	2009-08-07	19560778
Kinetics and mechanism for degradation of dichlorvos by permanganate in drinking water treatment.	2009-08	19515397
Determination of dialkyl phosphates as breakdown products of organophosphorus insecticides in fruit juices by HPTLC with fluorescence detection.	2009-07-21	19610356
A mass spectrometry-based method to measure dialkylphosphate degradation products of organophosphorous insecticides in dust and orange juice.	2009-07	20449223
Variation across the agricultural season in organophosphorus pesticide urinary metabolite levels for Latino farmworkers in eastern North Carolina: project design and descriptive results.	2009-07	19517490
Dimethyl [(4-fluoro-phen-yl)(6-methoxy-benzothia-zol-2-ylamino)meth-yl]phospho-nate.	2009-05-07	21583070
Analysis of dialkyl phosphate metabolites in hair using gas chromatography-mass spectrometry: a biomarker of chronic exposure to organophosphate pesticides.	2009-05	19399659
Dialkyl phosphates in meconium as a biomarker of prenatal exposure to organophosphate pesticides: a study on pregnant women of rural areas in Crete, Greece.	2009-05	19387892
Molecular dynamics simulations of a DMPC bilayer using nonadditive interaction models.	2009-01	19167291
Hydrolytic cleavage of an RNA-model phosphodiester catalyzed by a highly negatively charged polyoxomolybdate [Mo7O24]6- cluster.	2008-12-24	19053457
Theoretical investigation of the reaction mechanism for the phosphate diester hydrolysis using an asymmetric dinuclear metal complex as a biomimetic model of the purple acid phosphatase enzyme.	2008-12-14	19030600
Dialkylphosphates (DAPs) in fruits and vegetables may confound biomonitoring in organophosphorus insecticide exposure and risk assessment.	2008-11-26	18947233
Semen quality in Peruvian pesticide applicators: association between urinary organophosphate metabolites and semen parameters.	2008-11-17	19014632
Potential developmental neurotoxicity of pesticides used in Europe.	2008-10-22	18945337
Polyionic charge density plays a key role in differential recognition of mobile ions by biopolymers.	2008-07-31	18597519
A fatal dichlorvos poisoning: concentrations in biological specimens.	2008-07	18547356
Control of molecular fragmentation using shaped femtosecond pulses.	2008-05-01	18433144
Para niños saludables: a community intervention trial to reduce organophosphate pesticide exposure in children of farmworkers.	2008-05	18470300
Ca2+-dimethylphosphate complex formation: providing insight into Ca2+-mediated local dehydration and membrane fusion in cells.	2008-04	18452809
31P chemical shift tensors for canonical and non-canonical conformations of nucleic acids: a DFT study and NMR implications.	2008-03-20	18298109
A rapid, cost-effective method for analyzing organophosphorus pesticide metabolites in human urine for counter-terrorism response.	2008-02-14	18269802
Understanding membrane fusion combining experimental and simulation studies.	2008	19195551
[Electronic and spacial structure of orthophosphate and dimethylorthophosphate].	2007-10-03	17907400
A Staphylococcus aureus ypfP mutant with strongly reduced lipoteichoic acid (LTA) content: LTA governs bacterial surface properties and autolysin activity.	2007-08	17640274
Prenatal organophosphate metabolite and organochlorine levels and performance on the Brazelton Neonatal Behavioral Assessment Scale in a multiethnic pregnancy cohort.	2007-06-15	17406008
Organophosphate pesticide exposure and neurodevelopment in young Mexican-American children.	2007-05	17520070
Relationships between 31P chemical shift tensors and conformation of nucleic acid backbone: a DFT study.	2007-03-15	17315915
8-Hydroxydeoxyguanosine levels in human leukocyte and urine according to exposure to organophosphorus pesticides and paraoxonase 1 genotype.	2007-01	16915393
Dialkyl phosphate metabolites of organophosphorus in applicators of agricultural pesticides in Majes - Arequipa (Peru).	2006-12-19	17177990
Potential uses of biomonitoring data: a case study using the organophosphorus pesticides chlorpyrifos and malathion.	2006-11	17107865
Transition state analogues for nucleotidyl transfer reactions: Structure and stability of pentavalent vanadate and phosphate ester dianions.	2006-08-03	16869614
Organophosphate pesticide exposure and work in pome fruit: evidence for the take-home pesticide pathway.	2006-07	16835050
[Study on decomposed products of trichlorfon in process of gas chromatographic analysis by mass spectrometry].	2006-01	16827304
Theoretical studies of the hydroxide-catalyzed P-O cleavage reactions of neutral phosphate triesters and diesters in aqueous solution: examination of the changes induced by H/Me substitution.	2005-12-01	16853939
Thiolysis and alcoholysis of phosphate tri- and monoesters with alkyl and aryl leaving groups. An ab initio study in the gas phase.	2005-06-30	16833895
Cross-linked bis-hemoglobins: connections and oxygen binding.	2003-09-10	12952468

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 22:27:09 GMT 2025` Edited by `admin` on `Mon Mar 31 22:27:09 GMT 2025`
Record UNII	6Y9431DWHB
Record Status	`Validated (UNII)`
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Name

Type

Language

SODIUM DIMETHYL PHOSPHATE

Preferred Name

English

Classification Tree Code System Code

EPA PESTICIDE CODE

635002