Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C29H38N2O4.2ClH |
Molecular Weight | 551.545 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 2 / 2 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.Cl.[H][C@@]12CC(C[C@H]3NCCC4=CC(OC)=C(OC)C=C34)=C(CC)CN1CCC5=CC(OC)=C(OC)C=C25
InChI
InChIKey=WNJZDNXVVDNPSI-FJEGXLQFSA-N
InChI=1S/C29H38N2O4.2ClH/c1-6-18-17-31-10-8-20-14-27(33-3)29(35-5)16-23(20)25(31)12-21(18)11-24-22-15-28(34-4)26(32-2)13-19(22)7-9-30-24;;/h13-16,24-25,30H,6-12,17H2,1-5H3;2*1H/t24-,25+;;/m1../s1
Molecular Formula | C29H38N2O4 |
Molecular Weight | 478.623 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 2 / 2 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Molecular Formula | ClH |
Molecular Weight | 36.461 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Oral dehydroemetine dihydrochloride (+/-) (Mebadin) was found useful both as a tissue and contact amoebicide. It is much less toxic and more active than emetine and can be given in larger doses and for longer periods with safety. Owing to the quick excretion, repeat courses can be given at short intervals, as necessary, without danger. No serious side effects were noted particularly with the oral form and it was far better tolerated by children, who received relatively higher dosage than most adults. The only contra-indication is for patients with manifest decompensation of vital organs, or fevers. Mebadin injection and Mebadin tablets are discontinued products.
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
Ventricular tachycardia in a patient on dehydroemetine and chloroquine for amoebic liver abscess. | 1979 May 5 |
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Psychotrine and its O-methyl ether are selective inhibitors of human immunodeficiency virus-1 reverse transcriptase. | 1991 Dec 15 |
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Treatment of experimental pneumocystosis: review of 7 years of experience and development of a new system for classifying antimicrobial drugs. | 1992 Sep |
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[Fasciola hepatica. study of a series of 37 patients]. | 2001 Oct |
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Sonographic findings of hepatic lesions in human fascioliasis. | 2003 Sep |
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Histopathology of cutaneous amebiasis. | 2004 Aug |
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In vitro activity of antiamoebic drugs against clinical isolates of Entamoeba histolytica and Entamoeba dispar. | 2004 Dec 21 |
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[Hepatic fasciolasis diagnosed in state phase]. | 2006 Jan-Mar |
|
Development of a pharmacodynamic screening model with Entamoeba histolytica. | 2007 |
|
Targeting HSP90 for cancer therapy. | 2009 May 19 |
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 06:23:13 UTC 2023
by
admin
on
Sat Dec 16 06:23:13 UTC 2023
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Record UNII |
6Y45FL9GWY
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Record Status |
Validated (UNII)
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Record Version |
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-
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Code System | Code | Type | Description | ||
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DEHYDROEMETINE DIHYDROCHLORIDE
Created by
admin on Sat Dec 16 06:23:14 UTC 2023 , Edited by admin on Sat Dec 16 06:23:14 UTC 2023
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PRIMARY | Description: A white to yellowish, crystalline powder; odourless.Solubility: Sparingly soluble in water; soluble in methanol R.Category: Antiamoebic drug.Storage: Dehydroemetine dihydrochloride should be kept in a tightly closed container. | ||
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218-766-1
Created by
admin on Sat Dec 16 06:23:14 UTC 2023 , Edited by admin on Sat Dec 16 06:23:14 UTC 2023
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PRIMARY | |||
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2228-39-9
Created by
admin on Sat Dec 16 06:23:14 UTC 2023 , Edited by admin on Sat Dec 16 06:23:14 UTC 2023
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6Y45FL9GWY
Created by
admin on Sat Dec 16 06:23:14 UTC 2023 , Edited by admin on Sat Dec 16 06:23:14 UTC 2023
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PRIMARY | |||
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236465
Created by
admin on Sat Dec 16 06:23:14 UTC 2023 , Edited by admin on Sat Dec 16 06:23:14 UTC 2023
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PRIMARY | RxNorm | ||
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DTXSID50944940
Created by
admin on Sat Dec 16 06:23:14 UTC 2023 , Edited by admin on Sat Dec 16 06:23:14 UTC 2023
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PRIMARY | |||
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21124735
Created by
admin on Sat Dec 16 06:23:14 UTC 2023 , Edited by admin on Sat Dec 16 06:23:14 UTC 2023
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PRIMARY |
Related Record | Type | Details | ||
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PARENT -> SALT/SOLVATE |
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ACTIVE MOIETY |