DECARBOXY CARNOSINE HYDROCHLORIDE

Possibly Marketed Outside US

Details

Stereochemistry	ACHIRAL
Molecular Formula	C8H14N4O.2ClH
Molecular Weight	255.145
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of DECARBOXY CARNOSINE HYDROCHLORIDE

Structure Search

SMILES

Cl.Cl.NCCC(=O)NCCC1=CN=CN1

InChI

InChIKey=ZQTUNIWBUQUKAM-UHFFFAOYSA-N

InChI=1S/C8H14N4O.2ClH/c9-3-1-8(13)11-4-2-7-5-10-6-12-7;;/h5-6H,1-4,9H2,(H,10,12)(H,11,13);2*1H

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C8H14N4O
Molecular Weight	182.223
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/15466447 | https://www.ncbi.nlm.nih.gov/pubmed/7998987

Carcinine (beta-alanylhistamine) is a natural imidazole-containing peptide found in the non-protein fraction of mammalian tissues and possesses antioxidant and hydroxyl radical scavenging properties. Carcinine is also a selective histamine H3 antagonist.

CNS Activity

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Histamine H3 receptor 46 Target ID: Q9Y5N1 Gene ID: 11255.0 Gene Symbol: HRH3 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/15466447	Antagonist 2849		0.29 µM [Ki]
free radicals 4 Target ID: free radicals Sources: https://www.ncbi.nlm.nih.gov/pubmed/7998987	Binding Agent 1076

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2596

PubMed

Title	Date	PubMed
Alternative tasks of Drosophila tan in neurotransmitter recycling versus cuticle sclerotization disclosed by kinetic properties.	2010 Jul 2	20439462

Patents

Sample Use Guides

In Vivo Use Guide

in mice: carcinine at a dose of 20 mg kg(-1) slightly increased histidine decarboxylase (HDC) activity in the cortex (from 0.186+/-0.069 to 0.227+/-0.009 pmol mg protein(-1) min(-1)). In addition, carcinine (10, 20, and 50 mg kg(-1)) significantly decreased histamine levels in mice brain.

Route of Administration: Intraperitoneal

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 21:08:05 GMT 2025` Edited by `admin` on `Mon Mar 31 21:08:05 GMT 2025`
Record UNII	6X7K9I5QR7
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DECARBOXY CARNOSINE HYDROCHLORIDE

Common Name

English

DECARBOXY CARNOSINE HCL

Preferred Name

English

CARCININE (2HCL)

Brand Name

English

PROPANAMIDE, 3-AMINO-N-(2-(1H-IMIDAZOL-5-YL)ETHYL)-, HYDROCHLORIDE (1:2)

Systematic Name

English

.BETA.-ALANYLHISTAMINE DIHYDROCHLORIDE

Systematic Name

English

PROPANAMIDE, 3-AMINO-N-(2-(1H-IMIDAZOL-4-YL)ETHYL)-, DIHYDROCHLORIDE

Common Name

English

Carcinine dihydrochloride [WHO-DD]

Common Name

English

CARCININE DIHYDROCHLORIDE

Common Name

English

Code System Code Type Description

PUBCHEM

6419997