DECARBOXY CARNOSINE HYDROCHLORIDE

Possibly Marketed Outside US

Details

Stereochemistry	ACHIRAL
Molecular Formula	C8H14N4O.2ClH
Molecular Weight	255.145
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of DECARBOXY CARNOSINE HYDROCHLORIDE

Structure Search

SMILES

Cl.Cl.NCCC(=O)NCCC1=CN=CN1

InChI

InChIKey=ZQTUNIWBUQUKAM-UHFFFAOYSA-N

InChI=1S/C8H14N4O.2ClH/c9-3-1-8(13)11-4-2-7-5-10-6-12-7;;/h5-6H,1-4,9H2,(H,10,12)(H,11,13);2*1H

HIDE SMILES / InChI

Molecular Formula	C8H14N4O
Molecular Weight	182.223
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/15466447 | https://www.ncbi.nlm.nih.gov/pubmed/7998987

Carcinine (beta-alanylhistamine) is a natural imidazole-containing peptide found in the non-protein fraction of mammalian tissues and possesses antioxidant and hydroxyl radical scavenging properties. Carcinine is also a selective histamine H3 antagonist.

CNS Activity

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Histamine H3 receptor 44 Target ID: Q9Y5N1 Gene ID: 11255.0 Gene Symbol: HRH3 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/15466447	Antagonist 2778		0.29 µM [Ki]
free radicals 4 Target ID: free radicals Sources: https://www.ncbi.nlm.nih.gov/pubmed/7998987	Binding Agent 1064

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2578

PubMed

Title	Date	PubMed

Patents

Sample Use Guides

In Vivo Use Guide

in mice: carcinine at a dose of 20 mg kg(-1) slightly increased histidine decarboxylase (HDC) activity in the cortex (from 0.186+/-0.069 to 0.227+/-0.009 pmol mg protein(-1) min(-1)). In addition, carcinine (10, 20, and 50 mg kg(-1)) significantly decreased histamine levels in mice brain.

Route of Administration: Intraperitoneal

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Sat Dec 16 02:05:47 GMT 2023` Edited by `admin` on `Sat Dec 16 02:05:47 GMT 2023`
Record UNII	6X7K9I5QR7
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DECARBOXY CARNOSINE HYDROCHLORIDE

Common Name

English

CARCININE (2HCL)

Brand Name

English

PROPANAMIDE, 3-AMINO-N-(2-(1H-IMIDAZOL-5-YL)ETHYL)-, HYDROCHLORIDE (1:2)

Systematic Name

English

.BETA.-ALANYLHISTAMINE DIHYDROCHLORIDE

Systematic Name

English

PROPANAMIDE, 3-AMINO-N-(2-(1H-IMIDAZOL-4-YL)ETHYL)-, DIHYDROCHLORIDE

Common Name

English

DECARBOXY CARNOSINE HCL [INCI]

Common Name

English

DECARBOXY CARNOSINE HCL

Official Name

English

Carcinine dihydrochloride [WHO-DD]

Common Name

English

CARCININE DIHYDROCHLORIDE

Common Name

English

Code System Code Type Description

PUBCHEM

6419997