SORBITAN MONOLAURATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C18H34O6
Molecular Weight	346.459
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]1(OC[C@H](O)[C@H]1O)[C@H](O)COC(=O)CCCCCCCCCCC

InChI

InChIKey=LWZFANDGMFTDAV-BURFUSLBSA-N

InChI=1S/C18H34O6/c1-2-3-4-5-6-7-8-9-10-11-16(21)23-13-15(20)18-17(22)14(19)12-24-18/h14-15,17-20,22H,2-13H2,1H3/t14-,15+,17+,18+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C18H34O6
Molecular Weight	346.459
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: http://www.fao.org/fileadmin/user_upload/jecfa_additives/docs/Monograph1/Additive-431.pdf | https://www.drugs.com/inactive/sorbitan-monolaurate-462.html | https://www.crodahealthcare.com/en-gb/products-and-applications/product-finder/product/834/Span_1_20 | https://www.ulprospector.com/en/na/PersonalCare/Detail/134/50665/Span-20

Sorbitan laurate (Span 20) is a mixture of the partial esters of sorbitol and its mono- and dianhydrides with edible lauric acid. It is an excipient. Sorbitan laurate is a non-ionic surfactant that is widely used as an emulsifier and stabilizer in pharmaceutical formulations, food and cosmetic industries. As a food additive, it is designated with the E number E493. Span 20 finds application in topical preparations. It is soluble in many fatty compositions and solvents and dispersible in water, dilute acids and alkalis. Recommended topical usage levels of 0.5-5%.

Approval Year

PubMed

Title	Date	PubMed
The Behavior of Sorbitan Surfactants at the Water-Oil Interface: Straight-Chained Hydrocarbons from Pentane to Dodecane as an Oil Phase.	2001 Aug 1	11446810
Cyto/Genotoxicity study of polyoxyethylene (20) sorbitan monolaurate (tween 20).	2013 Sep	23844597
Ultrasonic Processing Technique as a Green Preparation Approach for Diacerein-Loaded Niosomes.	2017 Jul	27604883
Structures similar to lipid emulsions and liposomes. Dipalmitoylphosphatidylcholine, cholesterol, Tween 20-Span 20 or Tween 80-Span 80 in aqueous media.	2017 Jun	27050330
Oral delivery of allopurinol niosomes in treatment of gout in animal model.	2017 Jun	28067087

Patents

Sample Use Guides

In Vivo Use Guide

Recommended topical usage levels of 0.5-5%.

Route of Administration: Topical

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:01:17 UTC 2023` Edited by `admin` on `Fri Dec 15 15:01:17 UTC 2023`
Record UNII	6W9PS8B71J
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SORBITAN MONOLAURATE

Official Name

English

INS-493

Code

English

E-493

Code

English

SORBITAN LAURATE [EP MONOGRAPH]

Common Name

English

SORBITAN, MONODODECANOATE

Common Name

English

SORBITAN LAURATE [INCI]

Common Name

English

SORBITAN LAURATE [MART.]

Common Name

English

SORBITAN MONOLAURATE [II]

Common Name

English

SORBITAN MONOLAURATE [FCC]

Common Name

English

SORBITAN MONOLAURATE [VANDF]

Common Name

English

sorbitan laurate [INN]

Common Name

English

SORBITAN ESTERS SORBITAN LAURATE [MI]

Common Name

English

SORBITAN MONOLAURATE [USAN]

Common Name

English

SPAN 20

Brand Name

English

ANHYDROSORBITOL MONOLAURATE

Common Name

English

1,4-ANHYDRO-D-GLUCITOL, 6-DODECANOATE

Common Name

English

INS NO.493

Code

English

SORBITAN LAURATE

Official Name

English

Classification Tree Code System Code

JECFA EVALUATION

INS-493