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Details

Stereochemistry ABSOLUTE
Molecular Formula C18H34O6
Molecular Weight 346.459
Optical Activity UNSPECIFIED
Defined Stereocenters 4 / 4
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SORBITAN MONOLAURATE

SMILES

CCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O

InChI

InChIKey=LWZFANDGMFTDAV-BURFUSLBSA-N
InChI=1S/C18H34O6/c1-2-3-4-5-6-7-8-9-10-11-16(21)23-13-15(20)18-17(22)14(19)12-24-18/h14-15,17-20,22H,2-13H2,1H3/t14-,15+,17+,18+/m0/s1

HIDE SMILES / InChI
Molecular Formula C18H34O6
Molecular Weight 346.459
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 4 / 4
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

Sorbitan laurate (Span 20) is a mixture of the partial esters of sorbitol and its mono- and dianhydrides with edible lauric acid. It is an excipient. Sorbitan laurate is a non-ionic surfactant that is widely used as an emulsifier and stabilizer in pharmaceutical formulations, food and cosmetic industries. As a food additive, it is designated with the E number E493. Span 20 finds application in topical preparations. It is soluble in many fatty compositions and solvents and dispersible in water, dilute acids and alkalis. Recommended topical usage levels of 0.5-5%.

Approval Year

1973
95
PubMed

PubMed

TitleDatePubMed
Ultrasonic Processing Technique as a Green Preparation Approach for Diacerein-Loaded Niosomes.
2017-07
Structures similar to lipid emulsions and liposomes. Dipalmitoylphosphatidylcholine, cholesterol, Tween 20-Span 20 or Tween 80-Span 80 in aqueous media.
2017-06
Oral delivery of allopurinol niosomes in treatment of gout in animal model.
2017-06
Cyto/Genotoxicity study of polyoxyethylene (20) sorbitan monolaurate (tween 20).
2013-09
The Behavior of Sorbitan Surfactants at the Water-Oil Interface: Straight-Chained Hydrocarbons from Pentane to Dodecane as an Oil Phase.
2001-08-01
Patents

Patents

04231788
1
05179611
1
05278217
1
08361697
1
08399457
1
20100028257
1
20100297559
1

Sample Use Guides

In Vivo Use Guide
Recommended topical usage levels of 0.5-5%.
Route of Administration: Topical
Substance Class Chemical
Created
by admin
on Mon Mar 31 17:35:30 GMT 2025
Edited
by admin
on Mon Mar 31 17:35:30 GMT 2025
Record UNII
6W9PS8B71J
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SORBITAN MONOLAURATE
FCC   II   USAN   VANDF  
USAN  
Official Name English
SORBITAN LAURATE
EP   INCI   INN   MART.  
INN   INCI  
Preferred Name English
INS-493
Code English
E-493
Code English
SORBITAN LAURATE [EP MONOGRAPH]
Common Name English
SORBITAN, MONODODECANOATE
Common Name English
SORBITAN LAURATE [MART.]
Common Name English
SORBITAN MONOLAURATE [II]
Common Name English
SORBITAN MONOLAURATE [FCC]
Common Name English
SORBITAN MONOLAURATE [VANDF]
Common Name English
sorbitan laurate [INN]
Common Name English
SORBITAN ESTERS SORBITAN LAURATE [MI]
Common Name English
SORBITAN MONOLAURATE [USAN]
Common Name English
SPAN 20
Brand Name English
ANHYDROSORBITOL MONOLAURATE
Common Name English
1,4-ANHYDRO-D-GLUCITOL, 6-DODECANOATE
Common Name English
INS NO.493
Code English
Classification Tree Code System Code
JECFA EVALUATION INS-493
Created by admin on Mon Mar 31 17:35:30 GMT 2025 , Edited by admin on Mon Mar 31 17:35:30 GMT 2025
CODEX ALIMENTARIUS (GSFA) INS-493
Created by admin on Mon Mar 31 17:35:30 GMT 2025 , Edited by admin on Mon Mar 31 17:35:30 GMT 2025
NCI_THESAURUS C83486
Created by admin on Mon Mar 31 17:35:30 GMT 2025 , Edited by admin on Mon Mar 31 17:35:30 GMT 2025
Code System Code Type Description
ECHA (EC/EINECS)
215-663-3
Created by admin on Mon Mar 31 17:35:30 GMT 2025 , Edited by admin on Mon Mar 31 17:35:30 GMT 2025
PRIMARY
NCI_THESAURUS
C75653
Created by admin on Mon Mar 31 17:35:30 GMT 2025 , Edited by admin on Mon Mar 31 17:35:30 GMT 2025
PRIMARY
CAS
1338-39-2
Created by admin on Mon Mar 31 17:35:30 GMT 2025 , Edited by admin on Mon Mar 31 17:35:30 GMT 2025
PRIMARY
MERCK INDEX
m10120
Created by admin on Mon Mar 31 17:35:30 GMT 2025 , Edited by admin on Mon Mar 31 17:35:30 GMT 2025
PRIMARY Merck Index
DAILYMED
6W9PS8B71J
Created by admin on Mon Mar 31 17:35:30 GMT 2025 , Edited by admin on Mon Mar 31 17:35:30 GMT 2025
PRIMARY
SMS_ID
100000083772
Created by admin on Mon Mar 31 17:35:30 GMT 2025 , Edited by admin on Mon Mar 31 17:35:30 GMT 2025
PRIMARY
INN
1871
Created by admin on Mon Mar 31 17:35:30 GMT 2025 , Edited by admin on Mon Mar 31 17:35:30 GMT 2025
PRIMARY
ChEMBL
CHEMBL2107561
Created by admin on Mon Mar 31 17:35:30 GMT 2025 , Edited by admin on Mon Mar 31 17:35:30 GMT 2025
PRIMARY
PUBCHEM
11046239
Created by admin on Mon Mar 31 17:35:30 GMT 2025 , Edited by admin on Mon Mar 31 17:35:30 GMT 2025
PRIMARY
DRUG CENTRAL
3552
Created by admin on Mon Mar 31 17:35:30 GMT 2025 , Edited by admin on Mon Mar 31 17:35:30 GMT 2025
PRIMARY
RXCUI
1363055
Created by admin on Mon Mar 31 17:35:30 GMT 2025 , Edited by admin on Mon Mar 31 17:35:30 GMT 2025
PRIMARY RxNorm
EVMPD
SUB10597MIG
Created by admin on Mon Mar 31 17:35:30 GMT 2025 , Edited by admin on Mon Mar 31 17:35:30 GMT 2025
PRIMARY
WIKIPEDIA
Sorbitan monolaurate
Created by admin on Mon Mar 31 17:35:30 GMT 2025 , Edited by admin on Mon Mar 31 17:35:30 GMT 2025
PRIMARY
FDA UNII
6W9PS8B71J
Created by admin on Mon Mar 31 17:35:30 GMT 2025 , Edited by admin on Mon Mar 31 17:35:30 GMT 2025
PRIMARY
Related Record Type Details
Structure of SORBITAN MONOLAURATE
ACTIVE MOIETY
NIH
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