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Details

Stereochemistry RACEMIC
Molecular Formula C19H29IO2
Molecular Weight 416.3368
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ETHYL 10-(4-IODOPHENYL)UNDECANOATE

SMILES

CCOC(=O)CCCCCCCCC(C)C1=CC=C(I)C=C1

InChI

InChIKey=LAYLQVBQIBQVLL-UHFFFAOYSA-N
InChI=1S/C19H29IO2/c1-3-22-19(21)11-9-7-5-4-6-8-10-16(2)17-12-14-18(20)15-13-17/h12-16H,3-11H2,1-2H3

HIDE SMILES / InChI

Molecular Formula C19H29IO2
Molecular Weight 416.3368
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Description
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/18312083 http://www.wscj.org/pdf/pdf_WSCJ_74.pdf https://www.ncbi.nlm.nih.gov/pubmed/3175007

Iophendylate (Pantopaque (in USA) or Myodil, formerly manufactures by Glaxo Laboratories (London,UK) was commonly used from the 1940s until the late 1980s for myelography, cisternography, and ventriculography; the use of oil-based contrast agents such as Myodil has been discontinued, and images of intradural oil-based contrast are rarely encountered at present. In 1942 Van Wagenen (a neurosurgical colleague of Warrens, at the University of Rochester) identified Iophendylate as causing chemical meningitis in 30 patients where "space-displacing masses within the spinal canal were suspected". Iophendylate has been shown to be both a radiographic and magnetic resonance (MR) contrast agent in patients with suspected cord abnormalities who underwent MR examination following myelography. The iophendylate appears as a linear band of high signal intensity along the dependent portion of the spinal canal on MR images obtained with a repetition time of 500 msec and an echo time of 30 msec. Recently was published report, where depicted a unique case of posteriorly located subdural trapped Myodil, about three decades after myelography. The clinical picture of that case highlighted that such a complication didn’t carry the risk of arachnoiditis and could remain silent for several decades. Although Iophendylate is not used for evaluation of spinal disease anymore in the modern diagnostic era, its former use and its intrathecal persistence makes its recognition in MR imaging important. That case emphasized the necessity of awareness about these rare features which continue to present even decades after abandonment of oil-based myelography.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
PANTOPAQUE

Approved Use

Unknown

Launch Date

1943
PubMed

PubMed

TitleDatePubMed
Thoracic spinal iophendylate-induced arachnoiditis mimicking an intramedullary spinal cord neoplasm. Case report.
2008 Mar
Iophendylate myelography induced thoracic arachnoiditis, arachnoid cyst and syrinx, four decades later.
2010 Dec
Patents

Patents

Sample Use Guides

If oily iophendylate was used patient must lie flat for 8 to 12 hours
Route of Administration: Other
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:18:21 GMT 2023
Edited
by admin
on Fri Dec 15 15:18:21 GMT 2023
Record UNII
6V3I57K9UL
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ETHYL 10-(4-IODOPHENYL)UNDECANOATE
Systematic Name English
ETHYL 10-(P-IODOPHENYL)UNDECYLATE
Common Name English
ETHYL 10-(P-IODOPHENYL)HENDECANOATE
Common Name English
IOPHENDYLATE [MI]
Common Name English
BENZENEDECANOIC ACID, 4-IODO-.IOTA.-METHYL-, ETHYL ESTER
Common Name English
Code System Code Type Description
ECHA (EC/EINECS)
202-787-8
Created by admin on Fri Dec 15 15:18:21 GMT 2023 , Edited by admin on Fri Dec 15 15:18:21 GMT 2023
PRIMARY
CAS
99-79-6
Created by admin on Fri Dec 15 15:18:21 GMT 2023 , Edited by admin on Fri Dec 15 15:18:21 GMT 2023
PRIMARY
DRUG BANK
DB01187
Created by admin on Fri Dec 15 15:18:21 GMT 2023 , Edited by admin on Fri Dec 15 15:18:21 GMT 2023
PRIMARY
PUBCHEM
7458
Created by admin on Fri Dec 15 15:18:21 GMT 2023 , Edited by admin on Fri Dec 15 15:18:21 GMT 2023
PRIMARY
FDA UNII
6V3I57K9UL
Created by admin on Fri Dec 15 15:18:21 GMT 2023 , Edited by admin on Fri Dec 15 15:18:21 GMT 2023
PRIMARY
HSDB
3346
Created by admin on Fri Dec 15 15:18:21 GMT 2023 , Edited by admin on Fri Dec 15 15:18:21 GMT 2023
PRIMARY
MERCK INDEX
m6373
Created by admin on Fri Dec 15 15:18:21 GMT 2023 , Edited by admin on Fri Dec 15 15:18:21 GMT 2023
PRIMARY Merck Index
EPA CompTox
DTXSID2052869
Created by admin on Fri Dec 15 15:18:21 GMT 2023 , Edited by admin on Fri Dec 15 15:18:21 GMT 2023
PRIMARY