Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C19H29IO2 |
| Molecular Weight | 416.3368 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCOC(=O)CCCCCCCCC(C)C1=CC=C(I)C=C1
InChI
InChIKey=LAYLQVBQIBQVLL-UHFFFAOYSA-N
InChI=1S/C19H29IO2/c1-3-22-19(21)11-9-7-5-4-6-8-10-16(2)17-12-14-18(20)15-13-17/h12-16H,3-11H2,1-2H3
| Molecular Formula | C19H29IO2 |
| Molecular Weight | 416.3368 |
| Charge | 0 |
| Count |
|
| Stereochemistry | RACEMIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Optical Activity | ( + / - ) |
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/22333888Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/18312083
http://www.wscj.org/pdf/pdf_WSCJ_74.pdf
https://www.ncbi.nlm.nih.gov/pubmed/3175007
Sources: https://www.ncbi.nlm.nih.gov/pubmed/22333888
Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/18312083
http://www.wscj.org/pdf/pdf_WSCJ_74.pdf
https://www.ncbi.nlm.nih.gov/pubmed/3175007
Iophendylate (Pantopaque (in USA) or Myodil, formerly manufactures by Glaxo Laboratories (London,UK) was commonly used from the 1940s until the late 1980s for myelography, cisternography, and ventriculography; the use of oil-based contrast agents such as Myodil has been discontinued, and images of intradural oil-based contrast are rarely encountered at present. In 1942 Van Wagenen (a neurosurgical colleague of Warrens, at the University of Rochester) identified Iophendylate as causing chemical meningitis in 30 patients where "space-displacing masses within the spinal canal were suspected". Iophendylate has been shown to be both a radiographic and magnetic resonance (MR) contrast agent in patients with suspected cord abnormalities who underwent MR examination following myelography. The iophendylate appears as a linear band of high signal intensity along the dependent portion of the spinal canal on MR images obtained with a repetition time of 500 msec and an echo time of 30 msec. Recently was published report, where depicted a unique case of posteriorly located subdural trapped Myodil, about three decades after myelography. The clinical picture of that case highlighted that such a complication didn’t carry the risk of arachnoiditis and could remain silent for several decades. Although Iophendylate is not used for evaluation of spinal disease anymore in the modern diagnostic era, its former use and its intrathecal persistence makes its recognition in MR imaging important. That case emphasized the necessity of awareness about these rare features which continue to present even decades after abandonment of oil-based myelography.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: tumors Sources: https://www.ncbi.nlm.nih.gov/pubmed/22333888 |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Diagnostic | PANTOPAQUE Approved UseUnknown Launch Date1943 |
Sample Use Guides
If oily iophendylate was used patient must lie flat for 8 to 12 hours
Route of Administration:
Other
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3175007
Unknown
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 17:53:30 GMT 2025
by
admin
on
Mon Mar 31 17:53:30 GMT 2025
|
| Record UNII |
6V3I57K9UL
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Preferred Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
202-787-8
Created by
admin on Mon Mar 31 17:53:30 GMT 2025 , Edited by admin on Mon Mar 31 17:53:30 GMT 2025
|
PRIMARY | |||
|
99-79-6
Created by
admin on Mon Mar 31 17:53:30 GMT 2025 , Edited by admin on Mon Mar 31 17:53:30 GMT 2025
|
PRIMARY | |||
|
DB01187
Created by
admin on Mon Mar 31 17:53:30 GMT 2025 , Edited by admin on Mon Mar 31 17:53:30 GMT 2025
|
PRIMARY | |||
|
7458
Created by
admin on Mon Mar 31 17:53:30 GMT 2025 , Edited by admin on Mon Mar 31 17:53:30 GMT 2025
|
PRIMARY | |||
|
6V3I57K9UL
Created by
admin on Mon Mar 31 17:53:30 GMT 2025 , Edited by admin on Mon Mar 31 17:53:30 GMT 2025
|
PRIMARY | |||
|
3346
Created by
admin on Mon Mar 31 17:53:30 GMT 2025 , Edited by admin on Mon Mar 31 17:53:30 GMT 2025
|
PRIMARY | |||
|
m6373
Created by
admin on Mon Mar 31 17:53:30 GMT 2025 , Edited by admin on Mon Mar 31 17:53:30 GMT 2025
|
PRIMARY | Merck Index | ||
|
DTXSID2052869
Created by
admin on Mon Mar 31 17:53:30 GMT 2025 , Edited by admin on Mon Mar 31 17:53:30 GMT 2025
|
PRIMARY |