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Details

Stereochemistry ACHIRAL
Molecular Formula C2H6NO3S.K
Molecular Weight 163.237
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of POTASSIUM TAURATE

SMILES

[K+].NCCS([O-])(=O)=O

InChI

InChIKey=IMYBWPUHVYRSJG-UHFFFAOYSA-M
InChI=1S/C2H7NO3S.K/c3-1-2-7(4,5)6;/h1-3H2,(H,4,5,6);/q;+1/p-1

HIDE SMILES / InChI

Molecular Formula K
Molecular Weight 39.0983
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C2H6NO3S
Molecular Weight 124.139
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/3676193 | http://www.medscape.com/viewarticle/804080 | https://www.ncbi.nlm.nih.gov/pubmed/21334852 | https://www.ncbi.nlm.nih.gov/pubmed/26208967

Taurine is a semi-essential amino acid and is not incorporated into proteins. Taurine is considered conditionally essential because it cannot be synthesized by infants younger than 4-6 weeks, and it may not be adequately synthesized in patients receiving long-term parenteral nutrition and patients with short-term hypermetabolic conditions. In mammalian tissues, taurine is ubiquitous and is the most abundant free amino acid in the heart, retina, skeletal muscle, brain, and leukocytes. Taurin occurs naturally in fish and meat. The mean daily intake from omnivore diets was determined to be around 58 mg. Taurine is a component of energy drinks, with many contain 1000 mg per serving. In medicine, taurine supplementation demonstrated efficacy in relieving symptoms of heart failure, hepatitis, hypertension and psychotic disorder. Taurine exerts many physiological functions, including membrane stabilization, osmoregulation and cytoprotective effects, antioxidant and anti-inflammatory actions as well as modulation of intracellular calcium concentration and ion channel function. In addition taurine may control muscle metabolism and gene expression, through yet unclear mechanisms. The cellular and biochemical mechanisms mediating the actions of taurine are not fully known.

Originator

Curator's Comment: Taurin was first isolated from ox bile in 1827.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
406.0 µM [EC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
TAURINE

Approved Use

Taking 2-3 grams of taurine by mouth one to two times daily for 6-8 weeks seems to improve heart function and symptoms in patients with moderate heart failure to severe heart failure. Some patients with severe heart failure rapidly improve from NYHA class IV to II after 4-8 weeks of treatment. Improvement seems to continue for as long as taurine treatment is continued, up to one year.
Palliative
TAURINE

Approved Use

Taking 1.5-4 grams of taurine daily for up to 3 months improves liver function in people with hepatitis.
Preventing
URSA Complex

Approved Use

Taurine is a component of energy drinks used for relieving of fatigue
Primary
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Sodium nitroprusside-induced seizure and taurine release from rat hippocampus.
2000
Readiness potential in different states of physical activation and after ingestion of taurine and/or caffeine containing drinks.
2001
Creatine-supplemented diet extends Purkinje cell survival in spinocerebellar ataxia type 1 transgenic mice but does not prevent the ataxic phenotype.
2001
New developments in the pharmacotherapy of alcohol dependence.
2001
Low taurine, gamma-aminobutyric acid and carnosine levels in plasma of diabetic pregnant rats: consequences for the offspring.
2001
Two years' experience with Dialock and CLS (a new antimicrobial lock solution).
2001
Increased taurine content in esophageal mucosa of children affected by gastroesophageal reflux.
2001 Apr
Conditioned nutritional deficiencies in the cardiomyopathic hamster heart.
2001 Apr
Dipolar coupling and ordering effects observed in magnetic resonance spectra of skeletal muscle.
2001 Apr
Transport of L-carnitine in isolated cerebral cortex neurons.
2001 Apr
Depletion of taurine in experimental diabetic neuropathy: implications for nerve metabolic, vascular, and functional deficits.
2001 Apr
Endogenous glutamate-taurine interaction in striatum and nucleus accumbens of the freely moving rat: studies during the normal process of aging.
2001 Apr 15
Inhibition of the myeloperoxidase chlorinating activity by non-steroidal anti-inflammatory drugs investigated with a human recombinant enzyme.
2001 Apr 6
Mast cell numbers in the young rat thalamus: a search for control factors.
2001 Aug
Taurine increases rat survival and reduces striatal damage caused by 3-nitropropionic acid.
2001 Aug
Effects of new taurine derivatives on primary immune response in rats.
2001 Feb
[Role of angiotensin-(1-7) in amino-acid-neurotransmitter-mediated blood pressure regulation in rat rostral ventrolateral medulla].
2001 Feb
Energy-related metabolites during and after induced myocardial infarction with special emphasis on the reperfusion injury after extracorporeal circulation.
2001 Feb
The use of 1H magnetic resonance spectroscopy in inflammatory bowel diseases: distinguishing ulcerative colitis from Crohn's disease.
2001 Feb
Aging-induced changes in 24-h rhythms of mitogenic responses, lymphocyte subset populations and neurotransmitter and amino acid content in rat submaxillary lymph nodes during Freund's adjuvant arthritis.
2001 Feb
Chronic lamotrigine treatment increases rat hippocampal GABA shunt activity and elevates cerebral taurine levels.
2001 Feb
Taurine attenuates LPS-induced rolling and adhesion in rat microcirculation.
2001 Feb
An in vivo eyecup preparation for the rat.
2001 Feb 15
[Effect of taurine on the microvessel exchange function and adrenergic response of veins and arteries in the cat skeletal muscle].
2001 Jan
Effects of methionine loading on plasma and erythrocyte sulphur amino acids and sulph-hydryls before and after co-factor supplementation in haemodialysis patients.
2001 Jan
Taurine and osmoregulation: platelet taurine content, uptake, and release in type 2 diabetic patients.
2001 Jan
MR diffusion imaging and 1H spectroscopy in a child with medulloblastoma. A case report.
2001 Jan
Determination of bile acids in biological fluids by liquid chromatography-electrospray tandem mass spectrometry.
2001 Jan
A moderate decrease in temperature inhibits the calcium signaling mechanism(s) of the regulatory volume decrease in chick embryo cardiomyocytes.
2001 Jan
Studies on the effects of lactate transport inhibition, pyruvate, glucose and glutamine on amino acid, lactate and glucose release from the ischemic rat cerebral cortex.
2001 Jan
Neurotoxic effect of acamprosate, n-acetyl-homotaurine, in cultured neurons.
2001 Jan-Feb
The European acamprosate trials: conclusions for research and therapy.
2001 Jan-Feb
Taurine modulates catalase, aldehyde dehydrogenase, and ethanol elimination rates in rat brain.
2001 Jan-Feb
Taurine modulates arginine vasopressin-mediated regulation of renal function.
2001 Jun
Enhanced fungicidal activity of N-chlorotaurine in nasal secretion.
2001 Jun
Occupational lead exposure and amino acid profiles and liver function tests in industrial workers.
2001 Jun
Bile acid hydrophobicity is correlated with induction of apoptosis and/or growth arrest in HCT116 cells.
2001 Jun 1
Swelling-activated taurine and K+ transport in human cervical cancer cells: association with cell cycle progression.
2001 Mar
Effects of acamprosate on ethanol-seeking and self-administration in the rat.
2001 Mar
A new model for diffuse brain injury by rotational acceleration: II. Effects on extracellular glutamate, intracranial pressure, and neuronal apoptosis.
2001 Mar
Changes in apparent diffusion coefficients of metabolites in rat brain after middle cerebral artery occlusion measured by proton magnetic resonance spectroscopy.
2001 Mar
Alteration of excitation-contraction coupling mechanism in extensor digitorum longus muscle fibres of dystrophic mdx mouse and potential efficacy of taurine.
2001 Mar
Spinal taurine levels are increased 7 and 30 days following methylprednisolone treatment of spinal cord injury in rats.
2001 Mar 2
Mechanisms of alcohol-nicotine interactions: alcoholics versus smokers.
2001 May
The anti-craving compound acamprosate acts as a weak NMDA-receptor antagonist, but modulates NMDA-receptor subunit expression similar to memantine and MK-801.
2001 May
Characterization of the mouse bile salt export pump overexpressed in the baculovirus system.
2001 May
High glucose inhibits renal proximal tubule cell proliferation and involves PKC, oxidative stress, and TGF-beta 1.
2001 May
Cysteine regulates expression of cysteine dioxygenase and gamma-glutamylcysteine synthetase in cultured rat hepatocytes.
2001 May
Down-regulation of cholesterol 7alpha-hydroxylase (CYP7A1) gene expression by bile acids in primary rat hepatocytes is mediated by the c-Jun N-terminal kinase pathway.
2001 May 11
Further studies on the effects of topical lactate on amino acid efflux from the ischemic rat cortex.
2001 May 18
Patents

Sample Use Guides

Taurin occurs naturally in fish and meat. The mean daily intake from omnivore diets was determined to be around 58 mg.
Route of Administration: Oral
In Vitro Use Guide
Agonist properties of taurine on glycine receptor of supraoptic magnocellular neurones acutely dissociated from adult rats, using whole-cell voltage clamp. Responses to 1 mM taurine were blocked by strychnine but not by gabazine and showed no additivity with glycine-induced currents, indicating selective activation of glycine receptors.
Substance Class Chemical
Created
by admin
on Sat Dec 16 01:26:23 UTC 2023
Edited
by admin
on Sat Dec 16 01:26:23 UTC 2023
Record UNII
6U639090JA
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
POTASSIUM TAURATE
INCI  
INCI  
Official Name English
POTASSIUM 2-AMINOETHYLSULFONATE
Systematic Name English
REPARIN
Brand Name English
POTASSIUM TAURATE [INCI]
Common Name English
REPARINE
Brand Name English
TAURINE, MONOPOTASSIUM SALT
Common Name English
ETHANESULFONIC ACID, 2-AMINO-, POTASSIUM SALT (1:1)
Common Name English
POTASSIUM 2-AMINOETHANESULFONATE
Systematic Name English
ETHANESULFONIC ACID, 2-AMINO-, MONOPOTASSIUM SALT
Common Name English
Code System Code Type Description
PUBCHEM
23698856
Created by admin on Sat Dec 16 01:26:23 UTC 2023 , Edited by admin on Sat Dec 16 01:26:23 UTC 2023
PRIMARY
CAS
22890-34-2
Created by admin on Sat Dec 16 01:26:23 UTC 2023 , Edited by admin on Sat Dec 16 01:26:23 UTC 2023
PRIMARY
EPA CompTox
DTXSID70177430
Created by admin on Sat Dec 16 01:26:23 UTC 2023 , Edited by admin on Sat Dec 16 01:26:23 UTC 2023
PRIMARY
FDA UNII
6U639090JA
Created by admin on Sat Dec 16 01:26:23 UTC 2023 , Edited by admin on Sat Dec 16 01:26:23 UTC 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY