P-MENTHANE-3,8-DIOL

Details

Stereochemistry	MIXED
Molecular Formula	C10H20O2
Molecular Weight	172.2646
Optical Activity	UNSPECIFIED
Defined Stereocenters	0 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1CCC(C(O)C1)C(C)(C)O

InChI

InChIKey=LMXFTMYMHGYJEI-UHFFFAOYSA-N

InChI=1S/C10H20O2/c1-7-4-5-8(9(11)6-7)10(2,3)12/h7-9,11-12H,4-6H2,1-3H3

HIDE SMILES / InChI

Molecular Formula	C10H20O2
Molecular Weight	172.2646
Charge	0
Count

Stereochemistry	MIXED
Additional Stereochemistry	No
Defined Stereocenters	0 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: http://www.beyondpesticides.org/assets/media/documents/pesticides/factsheets/oillemoneucalyptus.pdf | https://www3.epa.gov/pesticides/chem_search/reg_actions/registration/fs_PC-011550_01-Apr-00.pdf | https://www.google.com/patents/WO2005087209A1?cl=en

p-Menthane-3,8-diol is a biochemical pesticide derived from eucalyptus plants. This active ingredient is used to make products that are applied to human skin and clothing for the purpose of repelling insects, such as mosquitoes. It can be used in two types of consumer pesticide products: a spray and a lotion. When used according to the label, p-Menthane-3,8-diol products are not expected to cause harm to humans or the environment. p-Menthane-3,8-diol is used on humans and their clothing to repel insects. Studies have shown that p-Menthane-3,8-diol gives protection against the biting midge, Culicoides variipennis Coquillett, the deer tick, Ixodes ricinis L., and the stable fly, Stomoxys calcitrans L. P-menthane-3,8-diol (PMD) has being studied as an antiviral agent.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Influenza A virus 9 Target ID: CHEMBL613740 Sources: https://www.google.com/patents/WO2005087209A1?cl=en	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Influenza virus infections 33 Sources: https://www.google.com/patents/WO2005087209A1?cl=en	Primary		Basic research	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed

Patents

Sample Use Guides

In Vivo Use Guide

Products containing p-Menthane-3,8-diol can be in the form of liquids that are sprayed on skin or clothing, or lotions that are rubbed on skin.

Route of Administration: Topical

In Vitro Use Guide

The toxicity of PMD (p-Menthane-3,8-diol) at the following concentrations in cell maintenance media was determined on a cell line with MDCK cells: • 2.5mg/ml (0.25% w/v) • 5mg/ml (0.5% w/v) • 20mg/ml (2% w/v). The results showed that using an influenza virus A/Sydney/5/97 on MDCK cells, there was no viral replication as evidenced by cell survival with 2% w/v PMD in the culture medium.

Substance Class	Chemical Created by `admin` on `Sat Dec 16 01:01:53 GMT 2023` Edited by `admin` on `Sat Dec 16 01:01:53 GMT 2023`
Record UNII	6T6Z1Z1NC4
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

P-MENTHANE-3,8-DIOL

Systematic Name

English

FEMA NO. 4053

Code

English

1-HYDROXY-5-METHYL-2-(1-METHYL-1-HYDROXYETHYL)CYCLOHEXANE

Systematic Name

English

GERANIUM CYCLOHEXANE

Common Name

English

P-MENTHANE-3,8-DIOL, (±)-

Systematic Name

English

GERANODYLE

Common Name

English

1-HYDROXY-2-(1-METHYL-1-HYDROXYETHYL)-5-METHYLCYCLOHEXANE

Systematic Name

English

CITRIODIOL

Common Name

English

(±)-P-MENTHANE-3,8-DIOL

Systematic Name

English

CYCLOHEXANEMETHANOL, 2-HYDROXY-.ALPHA.,.ALPHA.,4-TRIMETHYL-

Systematic Name

English

Citriodiol [WHO-DD]

Common Name

English

3,8-P-MENTHANEDIOL

Common Name

English

P-MENTHANE-3,8-DIOL [FHFI]

Common Name

English

Classification Tree Code System Code

EPA PESTICIDE CODE

11550