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Approval Year

Unknown
149124
Substance Class Structurally Diverse
Created
by admin
on Wed Apr 02 14:03:39 GMT 2025
Edited
by admin
on Wed Apr 02 14:03:39 GMT 2025
Source Materials Class ORGANISM
Source Materials Type RECOMBINANT VIRUS
Source Materials State LIVE CONDITIONALLY-REPLICATING GENETICALLY MODIFIED
Organism Family Herpesviridae
Organism Genus Simplexvirus
Organism Species human herpesvirus 1
Infraspecific Type RECOMBINANT VECTOR
Infraspecific Name HSV-1 strain F/deleted both ?34.5 and within the ?47 gene/inserted LacZ gene in the ICP6 locus
Part whole
Record UNII
6S57D3Y2F5
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
G-47.DELTA.
Preferred Name English
TESERPATUREV
INN  
Official Name English
teserpaturev [INN]
Common Name English
AN ONCOLYTIC HERPES SIMPLEX VIRUS-1 VECTOR CONTAINING MUTATIONS .GAMMA.34.5, ICP6 AND .ALPHA.47 WITH SELECTIVE TOXICITY TO TUMOR CELLS
Common Name English
A conditionally-replicating oncolytic Herpes simplex virus type 1 (HSV-1) strain F that has genetically engineered deletions within both copies of the ?34.5 gene and within the ?47 gene, and further modified by insertion of an expressible beta-galactosid
Common Name English
TESERPATUREV [WHO-DD]
Common Name English
Code System Code Type Description
CAS
1802360-34-4
Created by admin on Wed Apr 02 14:03:39 GMT 2025 , Edited by admin on Wed Apr 02 14:03:39 GMT 2025
PRIMARY
FDA UNII
6S57D3Y2F5
Created by admin on Wed Apr 02 14:03:39 GMT 2025 , Edited by admin on Wed Apr 02 14:03:39 GMT 2025
PRIMARY
INN
10794
Created by admin on Wed Apr 02 14:03:39 GMT 2025 , Edited by admin on Wed Apr 02 14:03:39 GMT 2025
PRIMARY
SMS_ID
100000183406
Created by admin on Wed Apr 02 14:03:39 GMT 2025 , Edited by admin on Wed Apr 02 14:03:39 GMT 2025
PRIMARY
NCI_THESAURUS
C190358
Created by admin on Wed Apr 02 14:03:39 GMT 2025 , Edited by admin on Wed Apr 02 14:03:39 GMT 2025
PRIMARY
Related Record Type Details
Teserpaturev expressed beta-galactosidase
TARGET->ENZYME REPLACEMENT
Human herpesvirus 1 strain F
PARENT ORGANISM->RECOMBINANT ORGANISM
Teserpaturev expressed beta-galactosidase
EXPRESSED PROTEIN->VECTOR
Related Record Type Details
TESERPATUREV
ACTIVE MOIETY

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
GENE DELETION Amount: ICP34.5 GENE (HSV-1) 7T9K17R530
GENE DELETION Amount: UNSPECIFIED SUBSTANCE
e04888f2
(not in database)
GENE ADDITION ICP6 locus Beta-galactosidase gene (teserpaturev) MF5ZNB9PDE
NIH
NCATS
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