TESERPATUREV

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Sat Dec 16 19:12:46 UTC 2023` Edited by `admin` on `Sat Dec 16 19:12:46 UTC 2023`
Source Materials Class	ORGANISM
Source Materials Type	RECOMBINANT VIRUS
Source Materials State	LIVE CONDITIONALLY-REPLICATING GENETICALLY MODIFIED
Organism Family	Herpesviridae
Organism Genus	Simplexvirus
Organism Species	human herpesvirus 1
Infraspecific Type	RECOMBINANT VECTOR
Infraspecific Name	HSV-1 strain F/deleted both γ34.5 and within the α47 gene/inserted LacZ gene in the ICP6 locus
Part	WHOLE
Record UNII	6S57D3Y2F5
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TESERPATUREV

Official Name

English

G-47.DELTA.

Code

English

teserpaturev [INN]

Common Name

English

AN ONCOLYTIC HERPES SIMPLEX VIRUS-1 VECTOR CONTAINING MUTATIONS .GAMMA.34.5, ICP6 AND .ALPHA.47 WITH SELECTIVE TOXICITY TO TUMOR CELLS

Common Name

English

A conditionally-replicating oncolytic Herpes simplex virus type 1 (HSV-1) strain F that has genetically engineered deletions within both copies of the γ34.5 gene and within the α47 gene, and further modified by insertion of an expressible beta-galactos

Common Name

English

TESERPATUREV [WHO-DD]

Common Name

English

Code System Code Type Description

CAS

1802360-34-4

Created by admin on Sat Dec 16 19:12:46 UTC 2023 , Edited by admin on Sat Dec 16 19:12:46 UTC 2023

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FDA UNII

6S57D3Y2F5

Created by admin on Sat Dec 16 19:12:46 UTC 2023 , Edited by admin on Sat Dec 16 19:12:46 UTC 2023

PRIMARY

INN

10794

Created by admin on Sat Dec 16 19:12:46 UTC 2023 , Edited by admin on Sat Dec 16 19:12:46 UTC 2023

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NCI_THESAURUS

C190358

Created by admin on Sat Dec 16 19:12:46 UTC 2023 , Edited by admin on Sat Dec 16 19:12:46 UTC 2023

PRIMARY

Related Record Type Details


					63Y3QRM6AT

Teserpaturev expressed beta-galactosidase

TARGET->ENZYME REPLACEMENT

Amount:


					6C8AKH4VPP

Human herpesvirus 1 strain F

PARENT ORGANISM->RECOMBINANT ORGANISM

Amount:


					63Y3QRM6AT

Teserpaturev expressed beta-galactosidase

EXPRESSED PROTEIN->VECTOR

Amount:

Related Record Type Details


					6S57D3Y2F5

TESERPATUREV

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Type	Extent	Fragment Name	Fragment Approval
GENE DELETION		Amount:	ICP34.5 GENE	7T9K17R530
GENE DELETION		Amount:	UNSPECIFIED SUBSTANCE	e04888f2 (not in database)
GENE ADDITION	ICP6 locus		Beta-galactosidase gene (teserpaturev)	MF5ZNB9PDE