in mice: niguldipine (up to 2.5 mg/kg) did not influence the electroconvulsive threshold in mice, although a higher dose of niguldipine (5 mg/kg) significantly elevated it.

The effect of increasing concentrations of daunomycin on the inhibition of cell growth in MCF-7/adr cells was examined in the absence and presence of the 4-aryl-1,4-dihydropyridines (Ia-q) and 4-arylpyridines (IIa-q). The control studies were performed using the vehicle (0.1% DMSO), whereas niguldipine (3 μM) served as a positive control. All of the compounds that significantly increased vinblastine accumulation were able to significantly decrease the IC50 values of daunomycin. If, Ih1, and Ih2, which did not affect drug accumulation, also did not lower the IC50 of daunomycin when compared with the control.