U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
This repository is under review for potential modification in compliance with Administration directives.

Approval Year

Unknown
149124
Substance Class Protein
Created
by admin
on Wed Apr 02 02:04:05 GMT 2025
Edited
by admin
on Wed Apr 02 02:04:05 GMT 2025
Protein Sub Type
Sequence Type COMPLETE
Record UNII
6P6Y82PIL1
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
LEUKOCYTE TYROSINE KINASE RECEPTOR
Common Name English
PROTEIN TYROSINE KINASE 1
Preferred Name English
TYK1
Common Name English
Code System Code Type Description
PHAROS
P29376
Created by admin on Wed Apr 02 02:04:05 GMT 2025 , Edited by admin on Wed Apr 02 02:04:05 GMT 2025
PRIMARY
WIKIPEDIA
LEUKOCYTE RECEPTOR TYROSINE KINASE
Created by admin on Wed Apr 02 02:04:05 GMT 2025 , Edited by admin on Wed Apr 02 02:04:05 GMT 2025
PRIMARY
FDA UNII
6P6Y82PIL1
Created by admin on Wed Apr 02 02:04:05 GMT 2025 , Edited by admin on Wed Apr 02 02:04:05 GMT 2025
PRIMARY
EC (ENZYME CLASS)
EC 2.7.10.1
Created by admin on Wed Apr 02 02:04:05 GMT 2025 , Edited by admin on Wed Apr 02 02:04:05 GMT 2025
PRIMARY
UNIPROT
P29376
Created by admin on Wed Apr 02 02:04:05 GMT 2025 , Edited by admin on Wed Apr 02 02:04:05 GMT 2025
PRIMARY
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_241
N 1_364
N 1_396
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INHIBITOR -> TARGET
Structure of K252A
INHIBITOR -> TARGET
Structure of GO-6976
INHIBITOR -> TARGET
Structure of SB-218078
INHIBITOR -> TARGET
Structure of SEMAXANIB
INHIBITOR -> TARGET
Structure of STAUROSPORINE
INHIBITOR -> TARGET
Structure of GILTERITINIB
INHIBITOR -> TARGET
Structure of PF-06439015
INHIBITOR -> TARGET

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO ACID SUBSTITUTION [1_660] TYROSINE TYROSINE O-PHOSPHATE 2R86C98KDX
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER AVERAGE(CALCULATED) CHEMICAL
NIH
NCATS
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