Phthalic acid

Details

Stereochemistry	ACHIRAL
Molecular Formula	C8H6O4
Molecular Weight	166.1308
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)C1=C(C=CC=C1)C(O)=O

InChI

InChIKey=XNGIFLGASWRNHJ-UHFFFAOYSA-N

InChI=1S/C8H6O4/c9-7(10)5-3-1-2-4-6(5)8(11)12/h1-4H,(H,9,10)(H,11,12)

HIDE SMILES / InChI

Molecular Formula	C8H6O4
Molecular Weight	166.1308
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Improved quantitative detection of 11 urinary phthalate metabolites in humans using liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometry.	2003-06-15	12742130
Quantitative changes in gene expression in fetal rat testes following exposure to di(n-butyl) phthalate.	2003-06	12700402
Determination of three phthalate metabolites in human urine using on-line solid-phase extraction-liquid chromatography-tandem mass spectrometry.	2003-05-25	12705982
Swelling and drug release behavior of tablets coated with aqueous hydroxypropyl methylcellulose phthalate (HPMCP) nanoparticles.	2003-04-29	12711446
Lack of sensitization for trimellitate, phthalate, terephthalate and isobutyrate plasticizers in a human repeated insult patch test.	2003-04	12615132
Transdermal iontophoresis of insulin. II. Physicochemical considerations.	2003-03-26	12623203
Development and optimization of a method for the analysis of low-molecular-mass organic acids in plants by capillary electrophoresis with indirect UV detection.	2003-03-14	12650261
An estimation of the daily intake of di(2-ethylhexyl)phthalate (DEHP) and other phthalates in the general population.	2003-03	12708228
Determination of low molecular weight organic acids in soil, plants, and water by capillary zone electrophoresis.	2003-03	12664177
Phthalate catabolic gene cluster is linked to the angular dioxygenase gene in Terrabacter sp. strain DBF63.	2003-03	12658514
Removal of bis(2-ethylhexyl) phthalate at a sewage treatment plant.	2003-03	12598201
Investigation of the adjuvant and immuno-suppressive effects of benzyl butyl phthalate, phthalic acid and benzyl alcohol in a murine injection model.	2003-03	12504176
Evaluation of the toxicity of polyvinylacetate phthalate in experimental animals.	2003-03	12504173
Air quality model evaluation data for organics. 6. C3-C24 organic acids.	2003-02-01	12630457
Degradation of phenanthrene and naphthalene by a Burkholderia species strain.	2003-02	12718402
Mono- and diesters from o-phthalic acid in leachates from different European landfills.	2003-02	12688695
Crystal structure of the 1:2:2 adduct of piperazine, o-phthalic acid and water.	2003-02	12608772
On-line clean-up by multidimensional liquid chromatography-electrospray ionization tandem mass spectrometry for high throughput quantification of primary and secondary phthalate metabolites in human urine.	2003-01-25	12504195
Development and application of a generalized physiologically based pharmacokinetic model for multiple environmental contaminants.	2003-01	12503743
Identification and fragmentation study of plasticizers with post-source decay matrix-assisted laser desorption/ionization mass spectrometry.	2003	12672131
Hap4p overexpression in glucose-grown Saccharomyces cerevisiae induces cells to enter a novel metabolic state.	2003	12537548
Gene expression changes induced in mouse liver by di(2-ethylhexyl) phthalate.	2002-12-15	12498735
A butyrylcholinesterase in the early development of the brine shrimp (Artemia salina) larvae: a target for phthalate ester embryotoxicity?	2002-12-13	12459190
In vitro effects of monophthalates on cytokine expression in the monocytic cell line THP-1 and in peripheral blood mononuclear cells from allergic and non-allergic donors.	2002-12	12423647
Simultaneous determination of phthalate di- and monoesters in poly(vinylchloride) products and human saliva by gas chromatography-mass spectrometry.	2002-11-15	12383478
The phthalate diesters DEHP and DBP do not induce lauric acid hydroxylase activity in rainbow trout.	2002-11-01	12408651
Environmental estrogens interact with and modulate the properties of plasma sex steroid-binding proteins in juvenile Atlantic salmon (Salmo salar).	2002-11-01	12408638
Adjuvant effect of di-n-butyl-, di-n-octyl-, di-iso-nonyl- and di-iso-decyl phthalate in a subcutaneous injection model using BALB/c mice.	2002-11	12570034
Ultrasound-assisted method for determination of chemical oxygen demand.	2002-11	12458432
Analytical potential of the reaction between p-phenylenediamines and peroxodisulfate for kinetic spectrophotometric determination of traces of ascorbic acid.	2002-11	12458429
Inhibition of oocyte development in Japanese medaka (Oryzias latipes) exposed to di-2-ethylhexyl phthalate.	2002-11	12437285
A novel class of self-sufficient cytochrome P450 monooxygenases in prokaryotes.	2002-11	12419614
Defining the cellular and molecular mechanisms of toxicant action in the testis.	2002-10-05	12270675
Absorption, disposition and metabolism of di-isononyl phthalate (DINP) in F-344 rats.	2002-10-02	12355558
Toxicity study of diethyl phthalate on freshwater fish Cirrhina mrigala.	2002-10	12568461
Reproductive and neurobehavioural toxicity study of bis(2-ethylhexyl) phthalate (DEHP) administered to mice in the diet.	2002-10	12387315
Phthalates and nonylphenols in profiles of differently dressed soils.	2002-09-16	12398330
Phthalates suppress the calcium signaling of nicotinic acetylcholine receptors in bovine adrenal chromaffin cells.	2002-09-01	12387748
Source reconciliation of atmospheric gas-phase and particle-phase pollutants during a severe photochemical smog episode.	2002-09-01	12322754
Characterization of the structures of poly(urea-urethane) microcapsules.	2002-08-21	12176237
Retention of ionizable compounds on HPLC. 12. The properties of liquid chromatography buffers in acetonitrile-water mobile phases that influence HPLC retention.	2002-08-01	12175170
Phthalates in underground waters of the Zagreb area.	2002-08	12187530
The peroxisome proliferator-activated receptor alpha (PPARalpha): role in hepatocarcinogenesis.	2002-07-31	12161004
Determination of adipate plasticizers in poly(vinyl chloride) by microwave-assisted extraction.	2002-07-19	12187996
Biochemical and structural changes in RBCs stored with different plasticizers: the role of hexanol.	2002-07	12375654
Slow-stir water solubility measurements of selected alcohols and diesters.	2002-07	12146613
Structural characterisation of humic acid-bound PAH residues in soil by 13C-CPMAS-NMR-spectroscopy: evidence of covalent bonds.	2002-07	12137049
Cytocompatibility of new phthalate ester-free tissue conditioners in vitro.	2002-06	12238781
Effect of phthalates on the stability and performance of AgBF4-PVP membranes for olefin/paraffin separation.	2001-10-21	12240157
[Effect of dibutyl phthalate on demodicidosis].	2001	12571942

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:51:53 GMT 2025` Edited by `admin` on `Mon Mar 31 18:51:53 GMT 2025`
Record UNII	6O7F7IX66E
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NSC-5348

Preferred Name

English

Phthalic acid

Systematic Name

English

FLUORESCEIN SODIUM IMPURITY B [EP IMPURITY]

Common Name

English

PHTHALIC ACID [MI]

Common Name

English

FLUORESCEIN IMPURITY B [EP IMPURITY]

Common Name

English

PHTHALIC ACID [USP IMPURITY]

Common Name

English

PHTHALIC ACID [USP-RS]

Common Name

English

BENZENE-1,2-DICARBOXYLIC ACID

Systematic Name

English

PHTHALIC ACID [HSDB]

Common Name

English

O-PHTHALIC ACID

Common Name

English

Code System Code Type Description

EPA CompTox

DTXSID8021484