N-NITROSOPIPERIDINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C5H10N2O
Molecular Weight	114.1457
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O=NN1CCCCC1

InChI

InChIKey=UWSDONTXWQOZFN-UHFFFAOYSA-N

InChI=1S/C5H10N2O/c8-6-7-4-2-1-3-5-7/h1-5H2

HIDE SMILES / InChI

Molecular Formula	C5H10N2O
Molecular Weight	114.1457
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
New short term prediction method for chemical carcinogenicity by hepatic transcript profiling following 28-day toxicity tests in rats.	2011	22084566
Determination of volatile nitrosamines in various meat products using comprehensive gas chromatography-nitrogen chemiluminescence detection.	2010-11	20816717
UVA activation of N-dialkylnitrosamines releasing nitric oxide, producing strand breaks as well as oxidative damages in DNA, and inducing mutations in the Ames test.	2010-09-10	20637784
Bronchogenic and alveologenic tumors in mice induced by N-nitrosopiperidine.	2010-08	20651851
Radical mechanisms in nitrosamine- and nitrosamide-induced whole-genome gene expression modulations in Caco-2 cells.	2010-07	20403970
Development of an in vitro system combining aqueous and lipid phases as a tool to understand gastric nitrosation.	2010-03-15	20112267
Screening of N-nitrosamines in tap and swimming pool waters using fast gas chromatography.	2010-03	20127916
N-Nitrosopiperidine and N-Nitrosodibutylamine induce apoptosis in HepG2 cells via the caspase dependent pathway.	2009-12	19748591
Myricetin, quercetin, (+)-catechin and (-)-epicatechin protect against N-nitrosamines-induced DNA damage in human hepatoma cells.	2009-10	19628030
Antiapoptotic effects of dietary antioxidants towards N-nitrosopiperidine and N-nitrosodibutylamine-induced apoptosis in HL-60 and HepG2 cells.	2009-07	19301245
Biogenic amines in fish: roles in intoxication, spoilage, and nitrosamine formation--a review.	2009-04	19234946
Molecular signatures of N-nitroso compounds in Caco-2 cells: implications for colon carcinogenesis.	2009-04	19221148
Identification of N-nitrosamines in treated drinking water using nanoelectrospray ionization high-field asymmetric waveform ion mobility spectrometry with quadrupole time-of-flight mass spectrometry.	2009-01	19161662
Synthesis of new 4-[2-(4-methyl(amino)sulfonylphenyl)-5-trifluoromethyl-2H-pyrazol-3-yl]-1,2,3,6-tetrahydropyridines: a search for novel nitric oxide donor anti-inflammatory agents.	2008-10-01	18789699
A cell-microelectronic sensing technique for profiling cytotoxicity of chemicals.	2008-05-12	18440366
Organosulfur compounds alone or in combination with vitamin C protect towards N-nitrosopiperidine- and N-nitrosodibutylamine-induced oxidative DNA damage in HepG2 cells.	2008-05-09	18339364
Induction of apoptosis and reactive oxygen species production by N-nitrosopiperidine and N-nitrosodibutylamine in human leukemia cells.	2008-05	17929238
Protective effects of isothiocyanates alone or in combination with vitamin C towards N-nitrosodibutylamine or N-nitrosopiperidine-induced oxidative DNA damage in the single-cell gel electrophoresis (SCGE)/HepG2 assay.	2008-03	17582584
Nitrosamine carcinogens also swim in chlorinated pools.	2008-02-15	18351068
N-nitrosodimethylamine (NDMA) removal by reverse osmosis and UV treatment and analysis via LC-MS/MS.	2008-01	17697696
Fat transforms ascorbic acid from inhibiting to promoting acid-catalysed N-nitrosation.	2007-12	17785370
Protective effect of vitamin C towards N-nitrosamine-induced DNA damage in the single-cell gel electrophoresis (SCGE)/HepG2 assay.	2007-10	17512695
Photochemical attenuation of N-nitrosodimethylamine (NDMA) and other nitrosamines in surface water.	2007-09-01	17937298
Evaluating the impacts of membrane type, coating, fouling, chemical properties and water chemistry on reverse osmosis rejection of seven nitrosoalklyamines, including NDMA.	2007-09	17582457
Analysis of nitrosamines by capillary electrospray-high-field asymmetric waveform ion mobility spectrometry-MS with programmed compensation voltage.	2007-05	17367110
Characterization of new nitrosamines in drinking water using liquid chromatography tandem mass spectrometry.	2006-12-15	17256506
Fate and transport of N-nitrosamines under conditions simulating full-scale groundwater recharge operations.	2006-12	17243246
[The promotive effects of N-nitrosopiperidine on the malignant transformation of the immortalized esophageal epithelium induced by human papillomavirus].	2006-06	16816872
Occurrence of N-nitrosodimethylamine in South Korean and imported alcoholic beverages.	2005-11	16332630
Automated solid-phase extraction and high-performance liquid chromatographic determination of nitrosamines using post-column photolysis and tris(2,2'-bipyridyl) ruthenium(III) chemiluminescence.	2005-06-03	15988986
Cytochrome P450 2A-catalyzed metabolic activation of structurally similar carcinogenic nitrosamines: N'-nitrosonornicotine enantiomers, N-nitrosopiperidine, and N-nitrosopyrrolidine.	2005-01	15651850
DNA damage and cytotoxicity in pancreatic beta-cells expressing human CYP2E1.	2004-08-01	15242818
Stereochemical effects in the metabolic activation of nitrosopiperidines: correlations with genotoxicity.	2004-03-14	15036118
N-Nitrosopiperidine.	2004	21105252
Preferential metabolic activation of N-nitrosopiperidine as compared to its structural homologue N-nitrosopyrrolidine by rat nasal mucosal microsomes.	2003-10	14565771
Extended-term cultures of human T-lymphocytes and the comet assay: a useful combination when testing for genotoxicity in vitro?	2003-09-09	12972057
Development of a new method for the determination of nitrosamines by micellar electrokinetic capillary chromatography.	2003-09	12909101
Comparative metabolism of N-nitrosopiperidine and N-nitrosopyrrolidine by rat liver and esophageal microsomes and cytochrome P450 2A3.	2003-02	12584180
Intake of volatile N-nitrosamines and their ability to exogenously synthesize in the diet of inhabitants from high-risk area of esophageal cancer in southern China.	2002-12	12642983
Dietary exposure and urinary excretion of total N-nitroso compounds, nitrosamino acids and volatile nitrosamine in inhabitants of high- and low-risk areas for esophageal cancer in southern China.	2002-11-20	12397637
Role of human cytochrome P450 (CYP) in the metabolic activation of nitrosamine derivatives: application of genetically engineered Salmonella expressing human CYP.	2002-08	12214673
Fast microwave-assisted dansylation of N-nitrosamines. Analysis by high-performance liquid chromatography with fluorescence detection.	2002-02-08	11873962
N-Nitrosopiperidine.	2002	15328585
Predicting the mutagenicity of tobacco-related N-nitrosamines in humans using 11 strains of Salmonella typhimurium YG7108, each coexpressing a form of human cytochrome P450 along with NADPH-cytochrome P450 reductase.	2001	11774366

Substance Class	Chemical Created by `admin` on `Mon Mar 31 19:15:19 GMT 2025` Edited by `admin` on `Mon Mar 31 19:15:19 GMT 2025`
Record UNII	6N066XUL4L
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

N-NITROSOPIPERIDINE

Systematic Name

English

NSC-138

Preferred Name

English

NPI

Common Name

English

NITROSOPIPERIDINE, N-

Systematic Name

English

1-NITROSOPIPERIDINE

Systematic Name

English

N-NITROSOPIPERIDINE [IARC]

Common Name

English

NPIP

Common Name

English

N-NITROSOPIPERIDINE [HSDB]

Common Name

English

PIPERIDINE, 1-NITROSO-

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C45402