HYDROXYDIONE HYDROGEN SUCCINATE

First approved in 1955

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C25H36O6
Molecular Weight	432.5497
Optical Activity	UNSPECIFIED
Defined Stereocenters	7 / 7
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of HYDROXYDIONE HYDROGEN SUCCINATE

Structure Search

SMILES

[H][C@@]12CC[C@H](C(=O)COC(=O)CCC(O)=O)[C@@]1(C)CC[C@@]3([H])[C@@]2([H])CC[C@]4([H])CC(=O)CC[C@]34C

InChI

InChIKey=KLRNMIUKAXHHFS-ZILYODKUSA-N

InChI=1S/C25H36O6/c1-24-11-9-16(26)13-15(24)3-4-17-18-5-6-20(25(18,2)12-10-19(17)24)21(27)14-31-23(30)8-7-22(28)29/h15,17-20H,3-14H2,1-2H3,(H,28,29)/t15-,17+,18+,19+,20-,24+,25+/m1/s1

HIDE SMILES / InChI

Molecular Formula	C25H36O6
Molecular Weight	432.5497
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	7 / 7
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: http://www.hmdb.ca/metabolites/HMDB0062609 | https://www.ncbi.nlm.nih.gov/pubmed/13329402 | https://www.ncbi.nlm.nih.gov/pubmed/1156941

HYDROXYDIONE is a neuroactive steroid used formerly as a general anesthetic. It was discontinued due to a high incidence of post-anesthetic thrombophlebitis, delayed onset of anesthesia and an unacceptably long duration of action.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
pain 5 Sources: https://www.ncbi.nlm.nih.gov/pubmed/13356183	Preventing		Approved 8429	Viadril Approved Use Unknown

Sourcing

Vendor/Aggregator	ID	URL
AAA Chemistry	AR-1D7886
ABI Chem	AC1L5X6T
ABI Chem	AC1Q6OLH
Chemieliva Pharmaceutical Co., Ltd	PBCM1266033
NCI Plated 2007	86000
NovoSeek	257630
THE BioTek	bt-432595	https://www.thebiotek.com/product/others/bt-432595
TimTec	ST50410049
Toronto Research Chemicals	H941558
ZINC	ZINC000004900230	http://zinc15.docking.org/substances/ZINC000004900230

PubMed

Title	Date	PubMed
Steroid anesthetic agent.	1955 Jul 8	14385824
Viadril: a new steroid anaesthetic; preliminary communication.	1956 Jul 21	13329402
Hydroxydione sodium (viadril) for anesthesia; a report of clinical experience.	1956 Sep	13356183

Substance Class	Chemical Created by `admin` on `Sat Dec 16 07:16:07 GMT 2023` Edited by `admin` on `Sat Dec 16 07:16:07 GMT 2023`
Record UNII	6LJJ67GNMV
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

HYDROXYDIONE HYDROGEN SUCCINATE

Common Name

English

5.BETA.-PREGNANE-3,20-DIONE, 21-HYDROXY-, HYDROGEN SUCCINATE

Common Name

English

PREGNANE-3,20-DIONE, 21-(3-CARBOXY-1-OXOPROPOXY)-, (5.BETA.)-

Systematic Name

English

5.BETA.-PREGNANE-3,20-DIONE, 21-HYDROXY-, SUCCINATE

Common Name

English

21-HYDROXY-5.BETA.-PREGNANE-3,20-DIONE SUCCINATE

Common Name

English

4-(2-((5R,8R,9S,10S,13S,14S,17S)-10,13-DIMETHYL-3-OXO-1,2,4,5,6,7,8,9,11,12,14,15,16,17-TETRADECAHYDROCYCLOPENTA(A)PHENANTHREN-17-YL)-2-OXO-ETHOXY)-4-OXO-BUTANOIC ACID

Common Name

English

Code System Code Type Description

PUBCHEM

5869